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I'm moving my mail infrastructure from mailup.com to an in house solution. I send roughly 65.000 emails a week and I'm aiming to double this within the next 6 months.

I gave a look at PhpList and GNU mailamn. What other options do I have?

I'm running CentOS and I can pick whatever MTA I prefer.

Mascarpone
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If you wont something very stable, easy use, and oldest software around that is still useful then I can recommend Citadel. It is fast, stable, easy to install, easy to use, and probably has more futures then you will ever need. The only thing is, it doesn't look pretty.

RoboTamer
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Take a look at some of these resource for more research:

https://stackoverflow.com/questions/1570943/whats-the-best-open-php-newsletter-manager

http://www.greepit.com/2010/03/best-open-source-email-marketing-software-roundup/

In the end, it depends on what kind of media you're mailing.

thinice
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