Ratchet and Clank: All 4 One/Funny

• In the first cutscene, right before Lawrence re-animates the Light-Eating Z'Grute, Nefarious screams in his ear like normal...only with a megaphone.
• After Nefarious repairs Commander Spog Qwark insists that Nefarious did the right thing. Nefarious's response?

Qwark: You did the right thing, Doctor!
Nefarious: Get bent!

• It was (sort of) featured in the trailer, but this exchange was great:

Nefarious: Can I kill him [Qwark] now?
Ratchet: No.
Nefarious: I can make it look like an accident!
Ratchet: (Beat) How?
Clank: Ratchet!

• There are four simple words that are almost guaranteed to make you crack a smile: Doctor Croid: Lombax Whisperer!

Qwark: Listen Doctor, I completely respect the fact that you're... insane.

• • This is revisited at the game's end, too:

Ratchet: Well, Dr. Croid seems to be doing better. Still keeps feeding me those treats... but otherwise, he seems surprisingly sane.

• There's also the Octonok Cay Tharpod, who tempted fate by saying that he was going to live the rest of his life free of tragic irony. There's a surprisingly long delay between this line and any further action, and you almost think that he's going to get away with it. Then the King Sepiad eats him. After scaling the lighthouse and beating the King Sepiad, the player(s) have probably written him off for dead, but as soon as the Sepiad keels over, the Tharpod claws his way out of its mouth, raving about the horrors he's seen inside of the Sepiad.
• The ending is is no slouch, either. Cronk and Zephyr finally make it down to Magnus after receiving aid from Lawrence, who proceeds to steal their ship, along with Dr. Nefarious. When someone raises the question as to how they're going to leave Magnus, Ratchet turns toward Ephemeris and promptly announces that he'll drive.
  • Right after that, we're treated to this exchange:

Clank: Ratchet! You cannot pilot a weaponized drone into Luminopolis!
Ratchet: Relax, pal-- I pilot weaponized drones into Luminopolis twice a week. It's like a ten bolt fine and a course that you have to take online. Qwark can pardon us.

Qwark: Perks of the job!

Clank: Oh, why do I even bother?

• • There's also a seemingly-random line coming from Croid around that same time:

Croid: What planet? Who the heck are you people?

• Qwark's offhand comment to Nefarious about "Two guys hugging it out" is made great by the awkward silence that follows it-- particularly after one Ho Yay filled scene right before Uzo City.
  • There's a similar moment after the party defeats Commander Spog and Clank says that he knows someone who can fix the Commander if he's willing to help them. Qwark assumes that Clank is talking about him, and offers a line of dialogue that falls somewhere between CMoF and Brain Bleach material.

Qwark: Well I don't mean to brag, but I did modify my crochitizer with a vibrate function that I like to call "The Happy Platypus"

• • • The others just stare at him until Clank finally says that he meant Nefarious.
      • The best part is Clank is the only one who looks genuinely disgusted. Ratchet and Nefarious have their hands to their chin as though they're contemplating it.
• Qwark's half-assed attempts at finding Nefarious in the intro video. Zephyr goes wandering through the background (of Polaris's Oval Office) and...

Qwark: Hey Zeph! You seen Dr. Nefarious?
Zephyr: Nope!
Qwark: See? The guy's a ghost!

• • The whole thing wasn't included in the teaser trailer, but it's best when seen in its completion:

Ratchet: Leave the hero stuff to the other guys.
Kip Darling: Like Galactic President Qwark?
Ratchet: (Beat) Yeah. Or... anyone else.
Clank: Ratchet...
Ratchet: (making an unenthusiastic effort to quiet himself) It's not like I voted for the guy...

• One of Qwark's Comically Missing the Point moments from early in the game:

Qwark: You've done some underhanded things in your time, but this beats all! I'm starting to think there may not even be an Inter-Galactic Tool of Justice Award!

Ratchet: Ladies and gentlemen, your president.

• Nefarious following the others into the Deadgrove because the elder Tharpod's bright pink creature creeped him out.
• After Cronk and Zephyr do some research on Nevo and discover that he may have sold Dr. Croid's technology behind his back Cronk lets out this line:

Cronk: I detect copious amounts of whippersnapperism!

• Die too many times around Ratchet?

Ratchet: You are such a noob.

• • Particularly hilarious if you're playing as him in single player. You hear him yelling, distressed, for Clank over and over... and then the above line completely blindsides you.
• Nefarious figures out where Ephemeris is

Ratchet: I'm impressed Nefarious. You did good. *offers fist*
Nefarious: *begrudgingly bumps fists*

• Dr. Croid's amazing "translation" skills:

Ratchet: Do you understand what I'm saying?
Dr. Croid: I think he needs to poo! I'll go get a baggie.
*Cue Ratchet, Clank and Nefarious's faces of disgust*
Qwark: Hey Doc. Better make that two. Been a looong trip.

• Normally, in Single-Player mode, if you play as Ratchet, Nefarious or Qwark, a CPU Clank will ride on your back like a backpack traditionally. However, if you play as Clank, Qwark will be your backpack instead.
• Maybe it's the delivery, but this hammy line is always good for a laugh.

Qwark: For our own survival, and for drama, we must set aside our petty squabbles and act together as a singular unit!

• "Fatty McMouth-Breather".
• The team discovers Vac-Us.

Qwark: Hmm, a letter... (Gasps happily) And it's been written in macaroni! "Dear Lombax. These Vac-Us will come in handy. Love Susie."
(Qwark turns on a Vac-U, and ends up suctioning Nefarious to it!)
Nefarious: (Trying to pull himself free) Let me go, you half-wit!
Qwark: I'm trying! Maybe if I just- (Pushes button on Vac-U and sends Nefarious flying. Cringes as a loud crash offscreen occurs.)