Ojamajo Doremi/Tear Jerker

• Ojamajo Doremi seemed to have at least two of these a season -- the second movie even ended in a heartbreaking Tear Jerker... and appropriately enough, it factored into Aiko's goal to reunite her parents late in Dokkan. Runner up is a 3 way tie between the Motto Christmas Episode, Littlest Cancer Patient Non-chan's death in Naisho episode 12, and the series finale.
• The entire twelfth episode from Naisho is a big Tear Jerker. To drive Non's death home, she was one of the few ordinary people to ever find out the existence of witches without transforming one into a frog in the process. Upon meeting Doremi (whom she didn't know was a witch-in-training yet), she had a feeling she could actually talk to her about it. Much later, Doremi decides to give her a taste of what it's like and even goes so far as to offer her to join if she gets well. The problem being that not only is Non's disease extremely bad, but none of the Ojamajos would be able to cure it without killing themself in the process, meaning that they just have to hope for the best. Later in the episode, Doremi goes to visit her... only to find her fighting for her life as the diseases hits terminal. After a shout to do her best fighting, she leaves since she can't take watching it... Even later, Non's mother comes to reveal that Doremi's words were enough to help Non fight off the disease, but only for a few minutes, leaving Non-chan dead. Afterwords, Doremi decides to fulfill Non-chan's other dream for her, being alive and well playing in the snow with her mother. The whole thing was so unbearably sad, especially since Both Doremi and Non really seemed to want to be together, especially part of the magical misadventures with her. I Think I need to lie down for a minute...
• Tear Jerker: Aiko's attempts to get her parents back together, Hazuki's borderline freak out over the incident with Nanako and her bunny, Momoko's backstory (which comes back with a vengeance at the end of Motto) among other moments
  • Actually, the series contains tons of Tear Jerker, some of them among the most well done emotional anime-scenes, this troper has ever seen. I am convinced that no human being should be able to watch the last episode of Sharp without bursting into tears. Also, the two last episodes of Naisho feature character death in it's most heartwrenchingly sad form.