WNT7A

Protein Wnt-7a is a protein that in humans is encoded by the WNT7A gene.[5][6][7]

WNT7A
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesWNT7A, Wnt family member 7A, Wnt-7a
External IDsOMIM: 601570 MGI: 98961 HomoloGene: 20969 GeneCards: WNT7A
Gene location (Human)
Chr.Chromosome 3 (human)[1]
Band3p25.1Start13,816,258 bp[1]
End13,880,071 bp[1]
RNA expression pattern
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez

7476

22421

Ensembl

ENSG00000154764

ENSMUSG00000030093

UniProt

O00755

P24383

RefSeq (mRNA)

NM_004625

NM_009527
NM_001363757

RefSeq (protein)

NP_004616

NP_033553
NP_001350686

Location (UCSC)Chr 3: 13.82 – 13.88 MbChr 6: 91.36 – 91.41 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Function

The WNT gene family consists of structurally related genes that encode secreted signaling proteins. These proteins have been implicated in oncogenesis and in several developmental processes, including regulation of cell fate and patterning during embryogenesis. This gene is a member of the WNT gene family. It encodes a protein showing 99% amino acid identity to the mouse Wnt7A protein. This gene not only guides the development of the anterior-posterior axis in the female reproductive tract but also plays a critical role in uterine smooth muscle pattering and maintenance of adult uterine function. It is also responsive to changes in the levels of sex steroid hormone in the female reproductive tract. Decreased expression of this gene in human uterine leiomyoma is found to be inversely associated with the expression of estrogen receptor alpha.[7]

References

  1. GRCh38: Ensembl release 89: ENSG00000154764 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000030093 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Ikegawa S, Kumano Y, Okui K, Fujiwara T, Takahashi E, Nakamura Y (Dec 1996). "Isolation, characterization and chromosomal assignment of the human WNT7A gene". Cytogenet Cell Genet. 74 (1–2): 149–52. doi:10.1159/000134404. PMID 8893824.
  6. Bui TD, Lako M, Lejeune S, Curtis AR, Strachan T, Lindsay S, Harris AL (Jun 1997). "Isolation of a full-length human WNT7A gene implicated in limb development and cell transformation, and mapping to chromosome 3p25". Gene. 189 (1): 25–9. doi:10.1016/S0378-1119(96)00808-6. PMID 9161407.
  7. "Entrez Gene: WNT7A wingless-type MMTV integration site family, member 7A".

Further reading


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