UK Coronavirus Cancer Monitoring Project

The UK Coronavirus Cancer Monitoring Project or UKCCMP[1] is a clinician-led reporting project supported to enable tracking of cancer patients who have tested positive for COVID-19 across the United Kingdom.[2]

UK Coronavirus Cancer Monitoring Project
Founded18 March 2020 (2020-03-18)
Key people
Lennard Lee, Gary Middleton, Rachel Kerr
Websiteukcoronaviruscancermonitoring.com

The project launched on 26 March 2020[3] and is one of the first emergency COVID-19 reporting project in cancer patients in the world. At the time, there was no way of tracking cancer patients with COVID-19 and the interactions of the COVID-19 virus and cancer and cancer treatment was unclear, with limited reporting based on small patient studies.[4][5] As a result, the reporting project launched as part of the United Kingdom's COVID-19 emergency response. The objective from the project is to identify and learn from every case of COVID-19 in cancer patients through the United Kingdom's 86 cancer centres.[6]

Support

The support from this project came from numerous groups. There was widespread support in the oncology professional communities including the Royal College of Radiologists[7], Association of Cancer Physicians[8] and Action Radiotherapy[9], with the Royal College of Radiologists noting that the project was an example of “best practice to benefit oncology patients”. Early academic institutional supporters were the University of Birmingham, University of Oxford and University of Leeds, and patient support groups include Macmillan Cancer Support.[10][11]

Funding

The project was launched in just 100 hours as a result of the pressing urgency of the clinical situation. The initial phases of funding were largely achieved through the donation of time and resources from the supporters and advocates of this project. The University of Birmingham played sizeable role in this process, with the Pro-Vice Chancellor dedicating the computational and human resources of the University's Centre for Computational Biology, the Institute of Translational Medicine and scientists from the Institute of Cancer and Genomic Sciences.

Organisation

All UK Cancer care centres were invited to participate in UKCCMP. Coronavirus Cancer Reporting was lead by a Local Emergency Response Reporting Group at cancer centre who typically included doctors, nurses and other medical health professionals.[12] Communication channels were rapidly established between UK cancer centres with local reporting of all COVID-19 presentations.

Impact

The project aimed to provide regular data releases to clinicians to provide insight of high clinical utility to inform and facilitate key decision makers[2] To this end, the project has encouraged a more collaborative approach to patient and clinical management across UK Cancer Centres.

The project was the joint first to recognise that the risk of COVID-19 and chemotherapy was significantly overstated. Previously, UK guidelines has suggested "patients with COVID-19 are at risk of severe disease following systemic anticancer treatment". [13] The UKCCMP identified that recent chemotherapy use did not significantly increase mortality from COVID-19 [14], and this was subsequently confirmed by a US cancer COVID-19 registry [15] and a French breast cancer registry.[16]

Project structure

The UK Coronavirus cancer monitoring project is a clinician-led reporting project which depends on the time and skills of the oncology community in the United Kingdom. The project was conceived on 18 March 2020 and launched on 26 March 2020 with support from the University of Birmingham and several oncology organisations within the United Kingdom.[3][11] The project team is chaired by Professor Gary Middleton, Professor Rachel Kerr and Dr Lennard Lee, and is composed of academic and clinical teams led by the scientific board for data acquisition, analysis and dissemination. The project management team consists of researchers from all major UK cancer centres including King's College London, University of Leeds, University of Edinburgh, the Clatterbridge Cancer Centre, University College London.[17]

References
  1. "Coronavirus Cancer Monitoring Project UK | Home". UK Coronavirus Cancer Monitoring.
  2. Anil, Iris; Arnold, Roland; Benkwitz-Beford, Sam; Branford, Simon; Campton, Naomi; Cazier, Jean-Baptiste; et al. (15 April 2020). "The UK Coronavirus Cancer Monitoring Project: protecting patients with cancer in the era of COVID-19". The Lancet Oncology. 21 (5): 622–624. doi:10.1016/S1470-2045(20)30230-8. ISSN 1470-2045. PMC 7159870. PMID 32304634. Retrieved 18 April 2020.
  3. "UK oncologists launch joint project to track cancer patients with COVID-19".
  4. Liang, Wenhua; Guan, Weijie; Chen, Ruchong; Wang, Wei; Li, Jianfu; Xu, Ke; et al. (1 March 2020). "Cancer patients in SARS-CoV-2 infection: a nationwide analysis in China". The Lancet Oncology. 21 (3): 335–337. doi:10.1016/S1470-2045(20)30096-6. ISSN 1470-2045. PMC 7159000. PMID 32066541. Retrieved 18 April 2020.
  5. Yu, Jing; Ouyang, Wen; Chua, Melvin L. K.; Xie, Conghua (25 March 2020). "SARS-CoV-2 Transmission in Patients With Cancer at a Tertiary Care Hospital in Wuhan, China". JAMA Oncology. 6 (7): 1108. doi:10.1001/jamaoncol.2020.0980. PMC 7097836. PMID 32211820.
  6. "Cancer Coronavirus Monitoring Project | About This Reporting Project".
  7. https://ukcoronaviruscancermonitoring.com/wp-content/uploads/2020/03/UK-Coronavirus-Project_RCR-Letter-of-support-redacted-signature-for-website.pdf
  8. https://ukcoronaviruscancermonitoring.com/wp-content/uploads/2020/03/UK-COVID19-Cancer-Reporting_ACP-Letter-of-Support-Redacted-signatures-for-website.pdf
  9. https://ukcoronaviruscancermonitoring.com/wp-content/uploads/2020/04/letter-of-support-from-AR.-final.-7th-Apr.pdf
  10. https://ukcoronaviruscancermonitoring.com/wp-content/uploads/2020/04/UK-Coronavirus-cancer-monitoring-scheme-letter-030420_nocontact.pdf
  11. "Coronavirus Project Supporters".
  12. "Coronavirus Cancer Reporting | UK Coronavirus Cancer Monitoring Project".
  13. https://www.nice.org.uk/guidance/ng161/chapter/3-Patients-known-or-suspected-to-have-COVID19
  14. https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(20)31173-9/fulltext
  15. https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(20)31187-9/fulltext
  16. Vuagnat, Perrine; Frelaut, Maxime; Ramtohul, Toulsie; Basse, Clémence; Diakite, Sarah; Noret, Aurélien; Bellesoeur, Audrey; Servois, Vincent; Hequet, Delphine; Laas, Enora; Kirova, Youlia; Cabel, Luc; Pierga, Jean-Yves; Bozec, Laurence; Paoletti, Xavier; Cottu, Paul; Bidard, François-Clément; Bidard, F. C. (2020). "COVID-19 in breast cancer patients: A cohort at the Institut Curie hospitals in the Paris area". Breast Cancer Research. 22 (1): 55. doi:10.1186/s13058-020-01293-8. PMC 7254663. PMID 32460829.
  17. "UK Coronavirus Cancer Project Team | Coronavirus Cancer Monitoring".
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