THJ-018

THJ-018 is a synthetic cannabinoid that is the indazole analogue of JWH-018 and has been sold online as a designer drug.[1][2]

THJ-018

Legal status
Legal status	CA: Schedule II DE: Anlage II (Authorized trade only, not prescriptible) UK: Under Psychoactive Substances Act
Identifiers
IUPAC name 1-Naphthalenyl(1-pentyl-1H-indazol-3-yl)-methanone
CAS Number	1364933-55-0^Y
ChemSpider	29341702
CompTox Dashboard (EPA)	DTXSID901010031
Chemical and physical data
Formula	C23H22N2O
Molar mass	342.442 g·mol^−1
3D model (JSmol)	Interactive image
SMILES O=C(C1=NN(CCCCC)C2=C1C=CC=C2)C3=C4C(C=CC=C4)=CC=C3
InChI InChI=1S/C23H22N2O/c1-2-3-8-16-25-21-15-7-6-13-20(21)22(24-25)23(26)19-14-9-11-17-10-4-5-12-18(17)19/h4-7,9-15H,2-3,8,16H2,1H3 Key:VAKGBPSFDNTMDJ-UHFFFAOYSA-N

Pharmacology

THJ-018 acts as a full agonist with a binding affinity of 5.84 nM at CB₁ and 4.57 nM at CB₂ cannabinoid receptors.[3]

Legality

THJ-018 is an Anlage II controlled drug in Germany.[4] It is also banned in Sweden.[5]

See also

• THJ-2201
• AM-2201

References

1. "THJ-018". Cayman Chemical. Retrieved 9 July 2015.
2. Diao X, Wohlfarth A, Pang S, Scheidweiler KB, Huestis MA (January 2016). "High-Resolution Mass Spectrometry for Characterizing the Metabolism of Synthetic Cannabinoid THJ-018 and Its 5-Fluoro Analog THJ-2201 after Incubation in Human Hepatocytes". Clinical Chemistry. 62 (1): 157–69. doi:10.1373/clinchem.2015.243535. PMID 26430074.
3. Hess C, Schoeder CT, Pillaiyar T, Madea B, Müller CE (2016). "Pharmacological evaluation of synthetic cannabinoids identified as constituents of spice". Forensic Toxicology. 34 (2): 329–343. doi:10.1007/s11419-016-0320-2. PMC 4929166. PMID 27429655.
4. "Gesetz über den Verkehr mit Betäubungsmitteln (Betäubungsmittelgesetz - BtMG) Anlage II (zu § 1 Abs. 1) (verkehrsfähige, aber nicht verschreibungsfähige Betäubungsmittel)" (in German). Retrieved 9 July 2015.
5. "Cannabinoider föreslås bli klassade som hälsofarlig vara" (in Swedish). Folkhälsomyndigheten. Retrieved 9 July 2015.