Oxymorphol

Oxymorphol is oxymorphone which has been hydrogenated at the 6-position and consists of a mixture of 4,5α-Epoxy-17-methylmorphinan-3,6β,14-triol and 4,5α-Epoxy-17-methylmorphinan-3,6α,14-triol (hydromorphinol).[1] . It is produced by the human body as an active metabolite of oxymorphone and some bacteria as an intermediate in turning morphine into hydromorphone. It can also be manufactured and is the subject of patents by drug companies looking for new semi-synthetic analgesics and cough suppressants.

Oxymorphol
Clinical data
Other names4,5α-Epoxy-17-methylmorphinan-3,6,14-triol
ATC code
Pharmacokinetic data
Metabolismhepatic
Identifiers
CAS Number
PubChem CID
ChemSpider
UNII
ChEMBL
Chemical and physical data
FormulaC17H21NO4
Molar mass303.358 g·mol−1
3D model (JSmol)

A derivative of oxymorphol, 8-hydroxy-6-α-oxymorphol, was discovered in the first decade of this century and the subject of a patent application by Endo for an analgesic and antitussive.[2]

References


This article is issued from Wikipedia. The text is licensed under Creative Commons - Attribution - Sharealike. Additional terms may apply for the media files.