Hagan Bayley

John Hagan Pryce Bayley FRS (born 13 February 1951[1]) is a British scientist, who holds the position of Professor of Chemical Biology at the University of Oxford.[5][6][7][8][9]

Hagan Bayley
Born
John Hagan Pryce Bayley

(1951-02-13) 13 February 1951[1]
Alma mater
Known for
Awards
Scientific career
FieldsChemical Biology
Institutions
ThesisAdamantylidene: A Hydrophobic, Photogenerated Reagent for the Characterization of Intrinsic Membrane Proteins (1979)
Doctoral advisorJeremy Knowles[4]
Websitebayley.chem.ox.ac.uk

Education

Bayley was educated at The King's School, Chester,[1] Balliol College, Oxford and Harvard University, where he was awarded a PhD in 1979.[4][10]

Research

Bayley's research is largely based on the study and engineering of transmembrane pore-forming proteins,[11] as well as interests in chemical signal transduction and biomolecular materials.[12] He is the co-founder of Oxford Nanopore Technologies Ltd. Bayley's research includes work on the pore-forming protein alpha haemolysin[13] engineered for sensing has been highly cited.[14]

Career

Following his PhD, Bayley completed postdoctoral research at Massachusetts Institute of Technology.[4] He previously held appointments at Columbia University, University of Massachusetts Medical School, and Texas A&M University.[4] Bayley has been based at the University of Oxford since 2003 and is a fellow of Hertford College, Oxford.[15]

Awards and honours

Bayley was elected a Fellow of the Royal Society in 2011.[3] His nomination reads

Hagan Bayley's achievements lie at the interface between chemistry and biology. He has used protein chemistry, organic chemistry, and biophysics to explore the folding, assembly, and function of transmembrane channels and pores. These studies have led to the development of protein pores as "nanoreactors", with which both non-covalent and covalent chemistry of single molecules can be examined. Applications of this methodology have included host–guest interactions and step-by-step polymer growth. Based on this work, Bayley has developed "stochastic sensing," which has been shown with a wide variety of analytes to reveal both concentration and identity through single-molecule detection.[3]

The Science Council recognised him as "one of the UK's 100 leading practising scientists" of 2014.[16]

References
  1. "BAYLEY, Prof. (John) Hagan (Pryce)". Who's Who. ukwhoswho.com. 2014 (online edition via Oxford University Press ed.). A & C Black, an imprint of Bloomsbury Publishing plc. (subscription or UK public library membership required) (subscription required)
  2. Branton, D.; Deamer, D. W.; Marziali, A.; Bayley, H.; Benner, S. A.; Butler, T.; Di Ventra, M.; Garaj, S.; Hibbs, A.; Huang, X.; Jovanovich, S. B.; Krstic, P. S.; Lindsay, S.; Ling, X. S.; Mastrangelo, C. H.; Meller, A.; Oliver, J. S.; Pershin, Y. V.; Ramsey, J. M.; Riehn, R.; Soni, G. V.; Tabard-Cossa, V.; Wanunu, M.; Wiggin, M.; Schloss, J. A. (2008). "The potential and challenges of nanopore sequencing". Nature Biotechnology. 26 (10): 1146–1153. doi:10.1038/nbt.1495. PMC 2683588. PMID 18846088.
  3. http://royalsociety.org/people/hagan-bayley/ Hagan Bayley at the Royal Society
  4. "CURRICULUM VITAE Hagan Bayley" (PDF). Retrieved 26 February 2018.
  5. http://bayley.chem.ox.ac.uk/ Bayley group at the University of Oxford
  6. http://research.chem.ox.ac.uk/hagan-bayley.aspx Hagan Bayley Research page
  7. Hagan Bayley's publications indexed by the Scopus bibliographic database. (subscription required)
  8. Braha, O.; Braha, H.; Conlan, L. Q.; Cheley, S.; Bayley, S. (1999). "Stochastic sensing of organic analytes by a pore-forming protein containing a molecular adapter". Nature. 398 (6729): 686–690. doi:10.1038/19491. PMID 10227291.
  9. Lou, H; Chen, M; Black, S. S.; Bushell, S. R.; Ceccarelli, M; Mach, T; Beis, K; Low, A. S.; Bamford, V. A.; Booth, I. R.; Bayley, H; Naismith, J. H. (2011). "Altered antibiotic transport in OmpC mutants isolated from a series of clinical strains of multi-drug resistant E. Coli". PLOS One. 6 (10): e25825. doi:10.1371/journal.pone.0025825. PMC 3203869. PMID 22053181.
  10. Bayley, Hagan (1979). Adamantylidene: A Hydrophobic, Photogenerated Reagent for the Characterization of Intrinsic Membrane Proteins (PhD thesis). Harvard University. ProQuest 302912373.
  11. Howorka, S.; Cheley, S.; Bayley, H. (2001). "Sequence-specific detection of individual DNA strands using engineered nanopores". Nature Biotechnology. 19 (7): 636–639. doi:10.1038/90236. PMID 11433274.
  12. Bayley, Hagan Profile at the University of Oxford Archived 17 January 2010 at the Wayback Machine
  13. Song, L.; Hobaugh, M. R.; Shustak, C.; Cheley, S.; Bayley, H.; Gouaux, J. E. (1996). "Structure of Staphylococcal alpha -Hemolysin, a Heptameric Transmembrane Pore". Science. 274 (5294): 1859–1865. doi:10.1126/science.274.5294.1859. PMID 8943190.
  14. Hagan Bayley publications indexed by Google Scholar
  15. Bayley, Hagan Profile at Hertford College
  16. https://www.timeshighereducation.com/news/the-uks-100-leading-practising-scientists/2010580.article


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