GUCY1A2

Guanylate cyclase soluble subunit alpha-2 is an enzyme that in humans is encoded by the GUCY1A2 gene.[5][6]

GUCY1A2
Identifiers
Aliases	GUCY1A2, GC-SA2, GUC1A2, guanylate cyclase 1, soluble, alpha 2, guanylate cyclase 1 soluble subunit alpha 2
External IDs	OMIM: 601244 MGI: 2660877 HomoloGene: 47953 GeneCards: GUCY1A2
Gene location (Human) Chr. Chromosome 11 (human)[1] Band 11q22.3 Start 106,674,012 bp[1] End 107,018,524 bp[1]
Gene location (Mouse) Chr. Chromosome 9 (mouse)[2] Band 9|9 A1 Start 3,532,778 bp[2] End 3,894,736 bp[2]
RNA expression pattern More reference expression data
Gene ontology Molecular function • GTP binding • heme binding • nucleotide binding • phosphorus-oxygen lyase activity • lyase activity • GO:0001948 protein binding • guanylate cyclase activity • adenylate cyclase activity Cellular component • cell membrane • guanylate cyclase complex, soluble • cytoplasm Biological process • signal transduction • GO:0007243 intracellular signal transduction • cyclic nucleotide biosynthetic process • cGMP biosynthetic process • positive regulation of nitric oxide mediated signal transduction Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	2977	234889
Ensembl	ENSG00000152402	ENSMUSG00000041624
UniProt	P33402	n/a
RefSeq (mRNA)	NM_001256424 NM_000855	NM_001033322
RefSeq (protein)	NP_000846 NP_001243353	n/a
Location (UCSC)	Chr 11: 106.67 – 107.02 Mb	Chr 9: 3.53 – 3.89 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

References

1. GRCh38: Ensembl release 89: ENSG00000152402 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000041624 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Harteneck C, Wedel B, Koesling D, Malkewitz J, Bohme E, Schultz G (Jan 1992). "Molecular cloning and expression of a new alpha-subunit of soluble guanylyl cyclase. Interchangeability of the alpha-subunits of the enzyme". FEBS Lett. 292 (1–2): 217–22. doi:10.1016/0014-5793(91)80871-Y. PMID 1683630.
6. "Entrez Gene: GUCY1A2 guanylate cyclase 1, soluble, alpha 2".

Further reading

• Baba H, Suzuki T, Arai H, Emson PC (2004). "Expression of nNOS and soluble guanylate cyclase in schizophrenic brain". NeuroReport. 15 (4): 677–80. doi:10.1097/00001756-200403220-00020. PMID 15094474.
• Bellamy TC, Wood J, Garthwaite J (2002). "On the activation of soluble guanylyl cyclase by nitric oxide". Proc. Natl. Acad. Sci. U.S.A. 99 (1): 507–10. doi:10.1073/pnas.012368499. PMC 117590. PMID 11752394.
• Russwurm M, Wittau N, Koesling D (2002). "Guanylyl cyclase/PSD-95 interaction: targeting of the nitric oxide-sensitive alpha2beta1 guanylyl cyclase to synaptic membranes". J. Biol. Chem. 276 (48): 44647–52. doi:10.1074/jbc.M105587200. PMID 11572861.
• Bamberger AM, Koglin M, Kempfert J, et al. (2001). "Expression and tissue localization of soluble guanylyl cyclase in the human placenta using novel antibodies directed against the alpha(2) subunit". J. Clin. Endocrinol. Metab. 86 (2): 909–12. doi:10.1210/jc.86.2.909. PMID 11158065.
• Budworth J, Meillerais S, Charles I, Powell K (1999). "Tissue distribution of the human soluble guanylate cyclases". Biochem. Biophys. Res. Commun. 263 (3): 696–701. doi:10.1006/bbrc.1999.1444. PMID 10512742.
• Yu F, Warburton D, Wellington S, Danziger RS (1997). "Assignment of GUCIA2, the gene coding for the alpha 2 subunit of soluble guanylyl cyclase, to position 11q21-q22 on human chromosome 11". Genomics. 33 (2): 334–6. doi:10.1006/geno.1996.0208. PMID 8660992.
• Behrends S, Harteneck C, Schultz G, Koesling D (1995). "A variant of the alpha 2 subunit of soluble guanylyl cyclase contains an insert homologous to a region within adenylyl cyclases and functions as a dominant negative protein". J. Biol. Chem. 270 (36): 21109–13. doi:10.1074/jbc.270.36.21109. PMID 7673142.