Fluorometholone

Fluorometholone (INN, BAN, JAN) (brand names Efflumidex, Flucon, FML Forte, FML, others), also known as 6α-methyl-9α-fluoro-11β,17α-dihydroxypregna-1,4-diene-3,20-dione, is a synthetic glucocorticoid which is used in the treatment of inflammatory eye diseases.[1][2][3] The C17α acetate ester, fluorometholone acetate (brand name Flarex), is also a glucocorticoid and is used for similar indications.[1][2][3] Specifically, it is indicated for use in the treatment of steroid-responsive inflammatory conditions of the palpebral and bulbar conjunctiva, cornea, and anterior segment of the eye.

Fluorometholone

Clinical data
Other names	(6S,8S,9R,10S,11S,13S,14S,17R)-17-acetyl-9-fluoro-11,17-dihydroxy-6,10,13-trimethyl-6,7,8,11,12,14,15,16-octahydrocyclopenta[a]phenanthren-3-one
AHFS/Drugs.com	Monograph
MedlinePlus	a682660
Pregnancy category	C
ATC code	C05AA06 (WHO) D07AB06 (WHO), D07XB04 (WHO) (combinations), D10AA01 (WHO), S01BA07 (WHO)
Identifiers
IUPAC name (1R,2S,8S,10S,11S,14R,15S,17S)-14-acetyl-1-fluoro-14,17-dihydroxy-2,8,15-trimethyltetracyclo[8.7.0.0^2,7.0^11,15]heptadeca-3,6-dien-5-one
CAS Number	426-13-1^Y
PubChem CID	9878
IUPHAR/BPS	7079
DrugBank	DB00324^Y
ChemSpider	9494^Y
UNII	SV0CSG527L
KEGG	D01367^Y
ChEBI	CHEBI:31625^N
ChEMBL	ChEMBL1200600^N
CompTox Dashboard (EPA)	DTXSID7047435
ECHA InfoCard	100.006.402
Chemical and physical data
Formula	C22H29FO4
Molar mass	376.468 g·mol^−1
3D model (JSmol)	Interactive image
SMILES O=C(C)[C@]3(O)[C@]2(C[C@H](O)[C@]4(F)[C@@]/1(\C(=C/C(=O)\C=C\1)[C@@H](C)C[C@H]4[C@@H]2CC3)C)C
InChI InChI=1S/C22H29FO4/c1-12-9-17-15-6-8-21(27,13(2)24)20(15,4)11-18(26)22(17,23)19(3)7-5-14(25)10-16(12)19/h5,7,10,12,15,17-18,26-27H,6,8-9,11H2,1-4H3/t12-,15-,17-,18-,19-,20-,21-,22-/m0/s1^Y Key:FAOZLTXFLGPHNG-KNAQIMQKSA-N^Y
^NY (what is this?)  (verify)

Most common indication for this drug is seasonal allergic conjunctivitis and other allergies of the eye.

See also

• 9α-Bromo-11-ketoprogesterone
• Flugestone
• Medrysone

References

1. Elks J (14 November 2014). The Dictionary of Drugs: Chemical Data: Chemical Data, Structures and Bibliographies. Springer. pp. 566–. ISBN 978-1-4757-2085-3.
2. Index Nominum 2000: International Drug Directory. Taylor & Francis. January 2000. pp. 458–. ISBN 978-3-88763-075-1.
3. Morton IK, Hall JM (6 December 2012). Concise Dictionary of Pharmacological Agents: Properties and Synonyms. Springer Science & Business Media. pp. 123–. ISBN 978-94-011-4439-1.

External links

• Drugs.com
• flarex
• Alcon official page
• Fluorometholone all you should know.