DNAJC1

DnaJ homolog subfamily C member 1 is a protein that in humans is encoded by the DNAJC1 gene.[5]

DNAJC1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2CQQ, 2CQR
Identifiers
Aliases	DNAJC1, DNAJL1, ERdj1, HTJ1, MTJ1, DnaJ heat shock protein family (Hsp40) member C1
External IDs	OMIM: 611207 MGI: 103268 HomoloGene: 7293 GeneCards: DNAJC1
Gene location (Human) Chr. Chromosome 10 (human)[1] Band 10p12.31 Start 21,756,548 bp[1] End 22,003,769 bp[1]
Gene location (Mouse) Chr. Chromosome 2 (mouse)[2] Band 2|2 A3 Start 18,195,654 bp[2] End 18,392,830 bp[2]
RNA expression pattern More reference expression data
Gene ontology Molecular function • DNA binding • ATPase activator activity • chaperone binding • GO:0001948 protein binding • GO:0001200, GO:0001133, GO:0001201 DNA-binding transcription factor activity, RNA polymerase II-specific Cellular component • integral component of membrane • organelle membrane • cell membrane • nuclear membrane • endoplasmic reticulum membrane • endoplasmic reticulum • membrane • cell nucleus • intracellular membrane-bounded organelle Biological process • negative regulation of proteolysis • protein folding • regulation of translation • regulation of protein secretion • positive regulation of ATPase activity • regulation of transcription from RNA polymerase II promoter Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	64215	13418
Ensembl	ENSG00000136770	ENSMUSG00000026740
UniProt	Q96KC8	Q61712
RefSeq (mRNA)	NM_022365	NM_001190817 NM_007869
RefSeq (protein)	NP_071760	NP_001177746 NP_031895
Location (UCSC)	Chr 10: 21.76 – 22 Mb	Chr 2: 18.2 – 18.39 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

Interactions

DNAJC1 has been shown to interact with Alpha 1-antichymotrypsin.[6]

References

1. GRCh38: Ensembl release 89: ENSG00000136770 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000026740 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. "Entrez Gene: DNAJC1 DnaJ (Hsp40) homolog, subfamily C, member 1".
6. Kroczynska B, Evangelista CM, Samant SS, Elguindi EC, Blond SY (2004). "The SANT2 domain of the murine tumor cell DnaJ-like protein 1 human homologue interacts with alpha1-antichymotrypsin and kinetically interferes with its serpin inhibitory activity". J. Biol. Chem. 279 (12): 11432–43. doi:10.1074/jbc.M310903200. PMC 1553221. PMID 14668352.

Further reading

• Kroczynska B, King-Simmons L, Alloza L, et al. (2006). "BIP co-chaperone MTJ1/ERDJ1 interacts with inter-alpha-trypsin inhibitor heavy chain 4". Biochem. Biophys. Res. Commun. 338 (3): 1467–77. doi:10.1016/j.bbrc.2005.10.101. PMID 16271702.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Deloukas P, Earthrowl ME, Grafham DV, et al. (2004). "The DNA sequence and comparative analysis of human chromosome 10". Nature. 429 (6990): 375–81. doi:10.1038/nature02462. PMID 15164054.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Kroczynska B, Evangelista CM, Samant SS, et al. (2004). "The SANT2 domain of the murine tumor cell DnaJ-like protein 1 human homologue interacts with alpha1-antichymotrypsin and kinetically interferes with its serpin inhibitory activity". J. Biol. Chem. 279 (12): 11432–43. doi:10.1074/jbc.M310903200. PMC 1553221. PMID 14668352.
• Lehner B, Semple JI, Brown SE, et al. (2004). "Analysis of a high-throughput yeast two-hybrid system and its use to predict the function of intracellular proteins encoded within the human MHC class III region". Genomics. 83 (1): 153–67. doi:10.1016/S0888-7543(03)00235-0. PMID 14667819.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Chevalier M, Rhee H, Elguindi EC, Blond SY (2000). "Interaction of murine BiP/GRP78 with the DnaJ homologue MTJ1". J. Biol. Chem. 275 (26): 19620–7. doi:10.1074/jbc.M001333200. PMC 1534116. PMID 10777498.

External links

• PDBe-KB provides an overview of all the structure information available in the PDB for Human DnaJ homolog subfamily C member 1