ATOH1

Protein atonal homolog 1 is a protein that in humans is encoded by the ATOH1 gene.[5][6]

ATOH1
Identifiers
Aliases	ATOH1, ATH1, HATH1, MATH-1, bHLHa14, atonal bHLH transcription factor 1
External IDs	OMIM: 601461 MGI: 104654 HomoloGene: 31297 GeneCards: ATOH1
Gene location (Human) Chr. Chromosome 4 (human)[1] Band 4q22.2 Start 93,828,753 bp[1] End 93,830,966 bp[1]
Gene location (Mouse) Chr. Chromosome 6 (mouse)[2] Band 6 C1|6 30.03 cM Start 64,729,125 bp[2] End 64,731,245 bp[2]
RNA expression pattern More reference expression data
Gene ontology Molecular function • DNA binding • sequence-specific DNA binding • protein dimerization activity • GO:0001131, GO:0001151, GO:0001130, GO:0001204 DNA-binding transcription factor activity • GO:0001077, GO:0001212, GO:0001213, GO:0001211, GO:0001205 DNA-binding transcription activator activity, RNA polymerase II-specific • GO:0000980 RNA polymerase II cis-regulatory region sequence-specific DNA binding • chromatin DNA binding • GO:0001200, GO:0001133, GO:0001201 DNA-binding transcription factor activity, RNA polymerase II-specific Cellular component • cell nucleus Biological process • Notch signaling pathway • regulation of neuron differentiation • auditory receptor cell fate determination • cell differentiation • positive regulation of auditory receptor cell differentiation • regulation of transcription, DNA-templated • positive regulation of inner ear receptor cell differentiation • negative regulation of apoptotic process • neuron migration • auditory receptor cell fate specification • transcription, DNA-templated • nervous system development • axon guidance • multicellular organism development • central nervous system development • brain development • auditory receptor cell differentiation • inner ear morphogenesis • positive regulation of neuron differentiation • neuron differentiation • cerebral cortex development • inner ear development • positive regulation of transcription from RNA polymerase II promoter • transcription from RNA polymerase II promoter Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	474	11921
Ensembl	ENSG00000172238	ENSMUSG00000073043
UniProt	Q92858	P48985
RefSeq (mRNA)	NM_005172	NM_007500
RefSeq (protein)	NP_005163	NP_031526
Location (UCSC)	Chr 4: 93.83 – 93.83 Mb	Chr 6: 64.73 – 64.73 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

Function

This protein belongs to the basic helix-loop-helix (BHLH) family of transcription factors. It activates E-box dependent transcription along with TCF3 (E47).[6] ATOH1 is required for the formation of both neural and non-neural cell types. Using genetic deletion in mice, Atoh1 has been shown to be essential for formation of cerebellar granule neurons, inner ear hair cells, spinal cord interneurons, Merkel cells of the skin, and intestinal secretory cells (goblet, enteroendocrine, and Paneth cells). ATOH1 is a mammalian homolog of the Drosophila melanogaster gene atonal. ATOH1 is considered part of the Notch signaling pathway.

In 2009, ATOH1 was identified as a "cancer switch-off" gene.

References

1. GRCh38: Ensembl release 89: ENSG00000172238 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000073043 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Ben-Arie N, McCall AE, Berkman S, Eichele G, Bellen HJ, Zoghbi HY (Sep 1996). "Evolutionary conservation of sequence and expression of the bHLH protein Atonal suggests a conserved role in neurogenesis". Human Molecular Genetics. 5 (9): 1207–16. doi:10.1093/hmg/5.9.1207. PMID 8872459.
6. "Entrez Gene: ATOH1 atonal homolog 1 (Drosophila)".

Further reading

• Helms AW, Johnson JE (Mar 1998). "Progenitors of dorsal commissural interneurons are defined by MATH1 expression". Development. 125 (5): 919–28. PMID 9449674.
• Dintilhac A, Bernués J (Mar 2002). "HMGB1 interacts with many apparently unrelated proteins by recognizing short amino acid sequences" (PDF). The Journal of Biological Chemistry. 277 (9): 7021–8. doi:10.1074/jbc.M108417200. PMID 11748221.
• Brown NL, Dagenais SL, Chen CM, Glaser T (Feb 2002). "Molecular characterization and mapping of ATOH7, a human atonal homolog with a predicted role in retinal ganglion cell development". Mammalian Genome. 13 (2): 95–101. doi:10.1007/s00335-001-2101-3. PMC 2262845. PMID 11889557.
• Leonard JH, Cook AL, Van Gele M, Boyle GM, Inglis KJ, Speleman F, Sturm RA (Sep 2002). "Proneural and proneuroendocrine transcription factor expression in cutaneous mechanoreceptor (Merkel) cells and Merkel cell carcinoma". International Journal of Cancer. 101 (2): 103–10. doi:10.1002/ijc.10554. PMID 12209986.
• Gazit R, Krizhanovsky V, Ben-Arie N (Feb 2004). "Math1 controls cerebellar granule cell differentiation by regulating multiple components of the Notch signaling pathway". Development. 131 (4): 903–13. doi:10.1242/dev.00982. PMID 14757642.
• Leow CC, Polakis P, Gao WQ (Nov 2005). "A role for Hath1, a bHLH transcription factor, in colon adenocarcinoma". Annals of the New York Academy of Sciences. 1059: 174–83. doi:10.1196/annals.1339.048. PMID 16382053.
• Sekine A, Akiyama Y, Yanagihara K, Yuasa Y (Jun 2006). "Hath1 up-regulates gastric mucin gene expression in gastric cells". Biochemical and Biophysical Research Communications. 344 (4): 1166–71. doi:10.1016/j.bbrc.2006.03.238. PMID 16647036.
• Mutoh H, Sakamoto H, Hayakawa H, Arao Y, Satoh K, Nokubi M, Sugano K (Jul 2006). "The intestine-specific homeobox gene Cdx2 induces expression of the basic helix-loop-helix transcription factor Math1". Differentiation; Research in Biological Diversity. 74 (6): 313–21. doi:10.1111/j.1432-0436.2006.00074.x. PMID 16831200.
• Park ET, Oh HK, Gum JR, Crawley SC, Kakar S, Engel J, Leow CC, Gao WQ, Kim YS (Sep 2006). "HATH1 expression in mucinous cancers of the colorectum and related lesions". Clinical Cancer Research. 12 (18): 5403–10. doi:10.1158/1078-0432.CCR-06-0573. PMID 17000673.
• Tsuchiya K, Nakamura T, Okamoto R, Kanai T, Watanabe M (Jan 2007). "Reciprocal targeting of Hath1 and beta-catenin by Wnt glycogen synthase kinase 3beta in human colon cancer". Gastroenterology. 132 (1): 208–20. doi:10.1053/j.gastro.2006.10.031. PMID 17241872.
• Du X, Jensen P, Goldowitz D, Hamre KM (May 2007). "Wild-type cells rescue genotypically Math1-null hair cells in the inner ears of chimeric mice". Developmental Biology. 305 (2): 430–8. doi:10.1016/j.ydbio.2007.02.028. PMID 17397818.
• Westerman BA, Breuer RH, Poutsma A, Chhatta A, Noorduyn LA, Koolen MG, Postmus PE, Blankenstein MA, Oudejans CB (2007). "Basic helix-loop-helix transcription factor profiling of lung tumors shows aberrant expression of the proneural gene atonal homolog 1 (ATOH1, HATH1, MATH1) in neuroendocrine tumors". The International Journal of Biological Markers. 22 (2): 114–23. doi:10.1177/172460080702200205. PMID 17549667.
• Scheffer D, Sage C, Corey DP, Pingault V (Oct 2007). "Gene expression profiling identifies Hes6 as a transcriptional target of ATOH1 in cochlear hair cells". FEBS Letters. 581 (24): 4651–6. doi:10.1016/j.febslet.2007.08.059. PMID 17826772.
• Shroyer NF, Helmrath MA, Wang VY, Antalffy B, Henning SJ, Zoghbi HY (Jun 2007). "Intestine-specific ablation of mouse atonal homolog 1 (Math1) reveals a role in cellular homeostasis". Gastroenterology. 132 (7): 2478–88. doi:10.1053/j.gastro.2007.03.047. PMID 17570220.

External links

• ATOH1+protein,+human at the US National Library of Medicine Medical Subject Headings (MeSH)
• ATOH1 and cancer suppression
• Human ATOH1 genome location and ATOH1 gene details page in the UCSC Genome Browser.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.