Zuotin

Z-DNA binding protein 1, also known as Zuotin, is a Saccharomyces cerevisiae yeast gene.

Zuotin
Identifiers
OrganismSaccharomyces cerevisiae
SymbolZUO1
UniProtP32527

Zuo1 has been identified in vitro as a tRNA and Z-DNA binding protein.[1][2] The name "zuotin" is derived from the Chinese word "zuo" meaning "left". It is a member of Hsp40 family. Like all other Hsp40 members it also contains a classic J domain.

Zuotin and related proteins contain a unique Zuotin homology domain (ZHD). It associates with the Hsp70 family Ssz1 to form a ribosome associated complex (RAC). In such a complex, the N-terminal domains (including the J domain) associates with Ssz1p on the surface of the large (60S) ribosomal subunit. ZHD provides further contacts with the 60S subunit and connects to a subunit-spanning medium domain (MD), the "neck" of RAC. The four-helix-bundle RAC head domain is located at the C-terminus and binds the small (40S) subunit. The J domain-Ssz1p complex, located over the peptide exit tunnel of the large ribosomal subunit, helps the nascent peptide fold.[3][4]

References
  1. Zhang S, Lockshin C, Herbert A, Winter E, Rich A (October 1992). "Zuotin, a putative Z-DNA binding protein in Saccharomyces cerevisiae". The EMBO Journal. 11 (10): 3787–96. doi:10.1002/j.1460-2075.1992.tb05464.x. PMC 556839. PMID 1396572.
  2. Wilhelm ML, Reinbolt J, Gangloff J, Dirheimer G, Wilhelm FX (August 1994). "Transfer RNA binding protein in the nucleus of Saccharomyces cerevisiae". FEBS Letters. 349 (2): 260–4. doi:10.1016/0014-5793(94)00683-0. PMID 8050578.
  3. Leidig C, Bange G, Kopp J, Amlacher S, Aravind A, Wickles S, et al. (January 2013). "Structural characterization of a eukaryotic chaperone--the ribosome-associated complex". Nature Structural & Molecular Biology. 20 (1): 23–8. doi:10.1038/nsmb.2447. PMID 23202586.
  4. Lee K, Sharma R, Shrestha OK, Bingman CA, Craig EA (November 2016). "Dual interaction of the Hsp70 J-protein cochaperone Zuotin with the 40S and 60S ribosomal subunits". Nature Structural & Molecular Biology. 23 (11): 1003–1010. doi:10.1038/nsmb.3299. PMC 5097012. PMID 27669034.
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