Zona pellucida-like domain

The Zona pellucida-like domain (ZP domain / ZP-like domain / ZP module)[1][2] is a large region, containing around 260 amino acids. It has been recognised in a variety of receptor-like eukaryotic glycoproteins.[1] All of these proteins are mosaic proteins composed of various domains and that all have a large extracellular region, often followed by either a transmembrane region and a very short cytoplasmic region or by a GPI-anchor.[2] Functional and crystallographic studies revealed that the "ZP domain" region common to all these proteins is a protein polymerization module that consists of two distinct but structurally related immunoglobulin-like domains, ZP-N and ZP-C.[3][4][5][6][7][8][9] The ZP module is located in the C-terminal portion of the extracellular region and - with the exception of non-polymeric family member ENG[10] - contains 8 or 10 conserved Cys residues involved in disulfide bonds.[5][6][9]

Zona pellucida-like domain
Identifiers
SymbolZona_pellucida
PfamPF00100
InterProIPR001507
SMARTSM00241
PROSITEPDOC00577
Membranome146

Additional copies of isolated ZP-N domains are found in the N-terminal region of egg coat protein subunits involved in fertilization in both vertebrates and invertebrates, such as human zona pellucida components ZP1, ZP2 and ZP4 and mollusk vitelline envelope receptor for egg lysin (VERL).[5][11][12]

Examples

Humans genes encoding proteins containing this domain include:

gollark: The `i` would still be a copy of the one in the list.
gollark: No, it would do the same thing.
gollark: When you loop over the tuple, `i` is *also* a new thing which can't affect the variables in the tuple.
gollark: (not that you can mutate tuples anyway)
gollark: So when you have `(a, b, c, d)` that (conceptually) creates a new copy of `b`, changes to which won't affect the original variable `b`.

References
  1. Bork P, Sander C (1992). "A large domain common to sperm receptors (Zp2 and Zp3) and TGF-beta type III receptor". FEBS Lett. 300 (3): 237–40. doi:10.1016/0014-5793(92)80853-9. PMID 1313375.
  2. Jovine L, Darie CC, Litscher ES, Wassarman PM (2005). "Zona pellucida domain proteins". Annu. Rev. Biochem. 74: 83–114. doi:10.1146/annurev.biochem.74.082803.133039. PMID 15952882.
  3. Jovine L, Qi H, Williams Z, Litscher E, Wassarman PM (2002). "The ZP domain is a conserved module for polymerization of extracellular proteins". Nat. Cell Biol. 4 (6): 457–61. doi:10.1038/ncb802. PMID 12021773.
  4. Jovine L, Qi H, Williams Z, Litscher ES, Wassarman PM (2004). "A duplicated motif controls assembly of zona pellucida domain proteins". Proc. Natl. Acad. Sci. U.S.A. 101 (16): 5922–7. doi:10.1073/pnas.0401600101. PMC 395899. PMID 15079052.
  5. Monné M, Han L, Schwend T, Burendahl S, Jovine L (2008). "Crystal structure of the ZP-N domain of ZP3 reveals the core fold of animal egg coats". Nature. 456 (7222): 653–7. doi:10.1038/nature07599. PMID 19052627. PDB: 3D4C, 3D4G, 3EF7​
  6. Han L, Monné M, Okumura, H, Schwend, T, Cherry, AL, Flot, D, Matsuda, T, Jovine, L (2010). "Insights into egg coat assembly and egg-sperm interaction from the X-ray structure of full-length ZP3". Cell. 143 (3): 404–15. doi:10.1016/j.cell.2010.09.041. PMID 20970175. PDB: 3NK3, 3NK4​
  7. Lin SJ, Hu Y, Zhu J, Woodruff TK, Jardetzky TS (2011). "Structure of betaglycan zona pellucida (ZP)-C domain provides insights into ZP-mediated protein polymerization and TGF-beta binding". Proc Natl Acad Sci U S A. 108 (13): 5232–6. doi:10.1073/pnas.1010689108. PMC 3069177. PMID 21402931. PDB: 3QW9​
  8. Diestel U, Resch M, Meinhardt K, Weiler S, Hellmann TV, Mueller TD, Nickel J, Eichler J, Muller YA (2013). "Identification of a Novel TGF-β-Binding Site in the Zona Pellucida C-terminal (ZP-C) Domain of TGF-β-Receptor-3 (TGFR-3)". PLOS ONE. 8 (6): e67214. doi:10.1371/journal.pone.0067214. PMC 3695229. PMID 23826237. PDB: 4AJV​
  9. Bokhove M, Nishimura K, Brunati M, Han L, de Sanctis D, Rampoldi L, Jovine L (2016). "A structured interdomain linker directs self-polymerization of human uromodulin". Proc. Natl. Acad. Sci. U.S.A. 113 (6): 1552–1557. doi:10.1073/pnas.1519803113. PMC 4760807. PMID 26811476. PDB: 4WRN, 5BUP​
  10. Saito T, Bokhove M, Croci R, Zamora-Caballero S, Han L, Letarte M, de Sanctis D, Jovine L (2017). "Structural Basis of the Human Endoglin-BMP9 Interaction: Insights into BMP Signaling and HHT1". Cell Reports. 19 (9): 1917–1928. doi:10.1016/j.celrep.2017.05.011. PMC 5464963. PMID 28564608. PDB: 5HZV​
  11. Callebaut I, Mornon JP, Monget P (2007). "Isolated ZP-N domains constitute the N-terminal extensions of Zona Pellucida proteins". Bioinformatics. 23: 1871–1874. doi:10.1093/bioinformatics/btm265. PMID 17510169.
  12. Raj I, Sadat Al Hosseini H, Dioguardi E, Nishimura K, Han L, Villa A, de Sanctis D, Jovine L (2017). "Structural Basis of Egg Coat-Sperm Recognition at Fertilization". Cell. 169 (7): 1315–1326. doi:10.1016/j.cell.2017.05.033. PMC 5480393. PMID 28622512. PDB: 5II4, 5II5, 5II6, 5MR2, 5IIC, 5IIA, 5IIB, 5MR3​
This article incorporates text from the public domain Pfam and InterPro: IPR001507


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