Xiaoliang Sunney Xie

Xiaoliang Sunney Xie (Chinese: 谢晓亮; born 1962 in Beijing, China) is a Chinese American biochemist, considered a founding father of single-molecule biophysical chemistry and single-molecule enzymology.[2]

For the singer, see Sunny Xie.
Xiaoliang Sunney Xie
Born (1962-06-24) June 24, 1962
Beijing, China
EducationBSc in Chemistry from Peking University
PhD in Physical Chemistry from UC San Diego
Known forSingle Molecule Enzymology,
Coherent Raman Imaging,
Single Cell Genomics
AwardsAlbany Prize in Medicine and Biomedical Research 2015,
Peter Debye Award in Physical Chemistry 2015,
Ellis R. Lippincott Award 2013,
Biophysical Society Founders Award 2012
NAS 2011
NAM 2016
CAS 2017
Scientific career
FieldsBiophysical Chemistry,
Optical Imaging,
Genomics
InstitutionsHarvard University
Peking University
Doctoral advisorJohn Douglas Simon[1]
This is a Chinese name; the family name is Xie.

Early life

He received his B.Sc. in Chemistry from Peking University in 1984, and his Ph.D. in Physical Chemistry in 1990 from University of California at San Diego. After a brief postdoctoral appointment at University of Chicago, he joined Pacific Northwest National Laboratory, where he rose from Senior Research Scientist to Chief Scientist. In 1998, he became the first tenured professor at Harvard University among Chinese Scholars who came to the United States since Chinese economic reform.

Research

He had been the Mallinckrodt Professor of Chemistry and Chemical Biology at Harvard University until 2018, when he became the Lee Shau-kee Professor of Peking University. Currently, he is also the Director of Biomedical Pioneering Innovation Center (BIOPIC), and the Director of Beijing Advanced Innovation Center for Genomics (ICG), both at Peking University.

As a pioneer of single-molecule biophysical chemistry, Coherent Raman scattering microscopy, and single-cell genomics, he made major contributions to the emergence of these fields. Furthermore, he has made significant advances on medical applications of label-free optical imaging and single-cell genomics. In particular, his inventions in single-cell genomics have been used in in vitro fertilization to benefit hundreds of couples in China by avoiding the transmission of monogenic diseases to their newborns.

As of Jan 2019, Xie has published over 226 papers. More than forty of his students and post-doctorates have become professors at major universities around the world, and two are co-founders of start-up companies. Professor Xie’s current research interests include the following scientific, technological, and medical areas:

  • Scientific: Single-molecule enzymology, Single-molecule biophysical chemistry, Gene expression and regulation, Epigenetics, Mechanism of cell differentiation and reprogramming, Chromosome structure and dynamics, and Genomic instability;
  • Technological: Single-molecule imaging, Single-cell genomics, Coherent Raman scattering microscopy, DNA sequencing;
  • Medical: Preimplantation genetic testing in in vitro fertilization, and Early cancer diagnosis

Honors and awards

Selected Literature

Single-Cell Genomics
  • Tan, Longzhi; Xie, X. Sunney. "A Near-complete Spatial Map of Olfactory Receptors in the Mouse Main Olfactory Epithelium". Chem Senses. 43 (6): 427–432.
  • Xu, Juanjuan; Fang, Rui; Chen, Li; Chen, Daozhen; Xiao, Jian-Ping; Yang, Weimin; Wang, Honghua; Song, Xiaoqing; Ma, Ting; Bo, Shiping; Shi, Chong; Ren, Jun; Huang, Lei; Cai, Li-Yi; Yao, Bing; Xie, X Sunney; Lu, Sijia (2016). "Noninvasive chromosome screening of human embryos by genome sequencing of embryo culture medium for in vitro fertilization". Proc Natl Acad Sci USA. 113 (42): 11907–1. doi:10.1073/pnas.1613294113.
  • Chen, Chongyi; Xing, Dong; Tan, Longzhi; Li, Heng; Zhou, Guangyu; Huang, Lei; Xie, X. Sunney (2017). "Single-cell whole-genome analyses by Linear Amplification via Transposon Insertion (LIANTI)". Science. 356: 189–194. Bibcode:2017Sci...356..189C. doi:10.1126/science.aak9787. PMC 5538131. PMID 28408603.
  • Yan, Liying; Huang, Lei; Xu, Liya; Huang, Jin; Ma, Fei; Zhu, Xiaohui; Tang, Yaqiong; Liu, Mingshan; Lian, Ying; Liu, Ping; Li, Rong; Lu, Sijia; Tang, Fuchou; Qiao, Jie; Xie, X Sunney (2015). "Live births after simultaneous avoidance of monogenic diseases and chromosome abnormality by next-generation sequencing with linkage analyses". Proc Natl Acad Sci USA. 112 (52): 15964–15969. Bibcode:2015PNAS..11215964Y. doi:10.1073/pnas.1523297113. PMC 4702982. PMID 26712022.
  • Hou, Yu; Fan, Wei; Yan, Liying; Li, Rong; Lian, Ying; Huang, Jin; Li, Jinsen; Xu, Liya; Tang, Fuchou; Xie, X. Sunney; Qiao, Jie (2013). "Genome Analyses of Single Human Oocytes". Cell. 155: 1492–1506. doi:10.1016/j.cell.2013.11.040.
  • Zong, Chenghang; Lu, Sijia; Chapman, Alec R.; Xie, X. Sunney (2012). "Genome-Wide Detection of Single-Nucleotide and Copy-Number Variations of a Single Human Cell". Science. 338: 1622–1626. Bibcode:2012Sci...338.1622Z. doi:10.1126/science.1229164. PMC 3600412. PMID 23258894.

Gene Expression and Regulation

Single Molecule Enzymology

Coherent Raman Imaging

Single Molecule Imaging
gollark: And yet people ENJOY consumption of HONEY?
gollark: How egocentric.
gollark: What, so you can just ignore EVERYONE ELSE and THEIR honey-related desires?
gollark: Bee removal would also negatively impact honey existence.
gollark: Interesting.

See also

References
  1. https://bernstein.harvard.edu/pages/AboutProfXie.html
  2. "Sunney Xie to receive Leibinger Research Prize for laser technology". Physics Today. 2013. doi:10.1063/pt.4.1557.
  3. http://newsen.pku.edu.cn/news_events/news/focus/6288.htm
  4. "关于公布2017年中国科学院院士增选当选院士名单的公告" (in Chinese). Chinese Academy of Sciences. 2017-11-28. Retrieved 2019-11-22.
  5. National Academy of Medicine Elects 79 New Members
  6. Albany Medical Center Prize
  7. Peter Debye Award
  8. NIH Director's Pioneer Award 2013
  9. Ellis R. Lippincott Award
  10. Berthold Leibinger Zukunftspreis
  11. Biography of Xie from the Website of the Willis E. Lamb Award (displayed June 4, 2008)
  12. NIH Director's Pioneer Award 2004
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