USP36

Ubiquitin-specific protease 36 is an enzyme that in humans is encoded by the USP36 gene. [5] [6]

USP36
Identifiers
Aliases	USP36, DUB1, ubiquitin specific peptidase 36
External IDs	OMIM: 612543 MGI: 1919594 HomoloGene: 11828 GeneCards: USP36
Gene location (Human) Chr. Chromosome 17 (human)[1] Band 17q25.3 Start 78,787,381 bp[1] End 78,841,441 bp[1]
Gene location (Mouse) Chr. Chromosome 11 (mouse)[2] Band 11|11 E2 Start 118,259,651 bp[2] End 118,290,244 bp[2]
RNA expression pattern More reference expression data
Gene ontology Molecular function • thiol-dependent ubiquitinyl hydrolase activity • peptidase activity • cysteine-type peptidase activity • hydrolase activity • thiol-dependent ubiquitin-specific protease activity • RNA binding Cellular component • nucleolus • cell nucleus • nuclear speck Biological process • protein deubiquitination • regulation of autophagy of mitochondrion • ubiquitin-dependent protein catabolic process • positive regulation of protein targeting to mitochondrion • proteolysis Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	57602	72344
Ensembl	ENSG00000055483	ENSMUSG00000033909
UniProt	Q9P275	B1AQJ2
RefSeq (mRNA)	NM_025090 NM_001321291	NM_001033528
RefSeq (protein)	NP_001308220	NP_001028700
Location (UCSC)	Chr 17: 78.79 – 78.84 Mb	Chr 11: 118.26 – 118.29 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

This gene encodes a member of the ubiquitin-specific protease family of proteases that is a deubiquitinating enzyme (DUB) with His and Cys domains. This protein is located in the nucleoli and deubuquitinate nucleophosmin and fibrillarin[7]

References

1. GRCh38: Ensembl release 89: ENSG00000055483 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000033909 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Puente XS, Sanchez LM, Overall CM, Lopez-Otin C (Jul 2003). "Human and mouse proteases: a comparative genomic approach". Nat Rev Genet. 4 (7): 544–558. doi:10.1038/nrg1111. PMID 12838346.
6. "Entrez Gene: USP36 ubiquitin specific peptidase 36".
7. Endo A, Matsumoto M, Inada T, Yamamoto A, Nakayama KI, Kitamura N, Komada M (Mar 2009). "Nucleolar structure and function are regulated by the deubiquitylating enzyme USP36". J Cell Sci. 122 (Pt 5): 678–86. doi:10.1242/jcs.044461. PMID 19208757.

Further reading

• Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–174. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–156. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
• Nagase T, Kikuno R, Ishikawa K, et al. (2000). "Prediction of the coding sequences of unidentified human genes. XVII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Res. 7 (2): 143–150. doi:10.1093/dnares/7.2.143. PMID 10819331.
• Scherl A, Couté Y, Déon C, et al. (2003). "Functional proteomic analysis of human nucleolus". Mol. Biol. Cell. 13 (11): 4100–4109. doi:10.1091/mbc.E02-05-0271. PMC 133617. PMID 12429849.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–16903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–45. doi:10.1038/ng1285. PMID 14702039.
• Quesada V, Díaz-Perales A, Gutiérrez-Fernández A, et al. (2004). "Cloning and enzymatic analysis of 22 novel human ubiquitin-specific proteases". Biochem. Biophys. Res. Commun. 314 (1): 54–62. doi:10.1016/j.bbrc.2003.12.050. PMID 14715245.
• Kim MS, Yoo KJ, Kang I, et al. (2005). "A novel cysteine protease HeLa DUB-1 responsible for cleaving the ubiquitin in human ovarian cancer cells". Int. J. Oncol. 25 (2): 373–9. doi:10.3892/ijo.25.2.373. PMID 15254734.
• Andersen JS, Lam YW, Leung AK, et al. (2005). "Nucleolar proteome dynamics". Nature. 433 (7021): 77–83. doi:10.1038/nature03207. PMID 15635413.
• Kim MS, Kim YK, Kim YS, et al. (2005). "Deubiquitinating enzyme USP36 contains the PEST motif and is polyubiquitinated". Biochem. Biophys. Res. Commun. 330 (3): 797–804. doi:10.1016/j.bbrc.2005.03.051. PMID 15809067.
• Nousiainen M, Silljé HH, Sauer G, et al. (2006). "Phosphoproteome analysis of the human mitotic spindle". Proc. Natl. Acad. Sci. U.S.A. 103 (14): 5391–5396. doi:10.1073/pnas.0507066103. PMC 1459365. PMID 16565220.
• Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–648. doi:10.1016/j.cell.2006.09.026. PMID 17081983.