Tunga penetrans

Tunga penetrans (chigoe flea or jigger) is a parasitic insect found in most tropical and sub-tropical climates. It is native to Central and South America, and has been inadvertently introduced by humans to sub-Saharan Africa.[1]

This article is about the parasite called chigoe flea or jigger. For the unrelated mite called chigger, see Trombiculidae.

Jigger flea
Scientific classification
Kingdom:
Animalia
Phylum:
Arthropoda
Class:
Insecta
Order:
Siphonaptera
Family:
Hectopsyllidae
Genus:
Tunga
Species:
T. penetrans
Binomial name
Tunga penetrans

Synonyms for Tunga penetrans include Sarcopsylla penetrans, Pulex penetrates, and many others.[2] In its parasitic phase it has significant impact on its host, which include humans and certain other mammalian species. A parasitical infestation of T. penetrans is called tungiasis.

Identification
Tunga penetrans
Jigger (sand flea) infested foot

T. penetrans is the smallest known flea, at only 1 mm. It is most recognizable in its parasite phase. While embedded under the stratum corneum layer of the skin, it may reach up to 1 cm across. During the first day or two of infestation, the host may feel an itching or irritation which then passes as the area around the flea calluses and becomes insensitive. As the flea's abdomen swells with eggs later in the cycle, the pressure from the swelling may press neighbouring nerves or blood vessels. Depending on the exact site, this can cause sensations ranging from mild irritation to serious discomfort.

Local terms for T. penetrans
In South SudanTukutuku, Zande Language
In BrazilBicho de pé (foot bug), in Brazilian Portuguese
in Central America, Colombia, Ecuador, Mexico, Peru and Bolivianigua
In Democratic Republic of the CongoKikongo speaking Ntanda
In Democratic Republic of the CongoLingala speaking liyanzi (singular) or mayanzi (plural)
In Democratic Republic of the CongoSwahili speaking Fundja
In Democratic Republic of the CongoTshiluba speaking Kabwassa
In Great Britainjigger, sand flea
In EthiopiaMujale
In Guaranitũ
In French GuianaFrench speaking Puce-chique
In Kinyarwanda and Kirundiivunja or imvunja (singular) or amavunja (plural)
In Kiswahilifunza
In Gikuyundutu
In LuhyaTsiinyende
In LuoMineme
In Lugandanvunza
In MadagascarParasy
In Spanishpique (due to the itching and burning sensation it produces)
In Surinamesika
In West Indiachigoe
In Yorubajiga, directly translated from the term jigger

[credits: Gordon, 1941; Bruce et al, 1942; Grosshans and Pradinaud, 1979; Macias and Sashida, 2000; Muehlen et al, 2003; Sachse et al, 2007]

Distinction

The colloquial name jigger may be confused with chigger, a parasitical mite. However, the jigger is of the order Siphonaptera as it is a flea. The chigger is a minute arachnid.[3] Mites penetrate the skin and feed on skin cells that are broken down through an enzyme they secrete from their mouth, but they will then leave the host. The adult and the larval forms both feed on other animals. This is not the case with T. penetrans, as only the adults feed on mammals, and the mature female remains in the host for the rest of her life.

Genus and hosts

T. penetrans is unusual for the 13 known species of the genus Tunga. First, it has a wide distribution: some 88 countries, in the Caribbean, Central and South America, tropical (sub-Saharan) Africa, and India. Second, It can infest a wide variety of hosts: at least 26 different species in over 5 different orders of mammals.

In contrast, most of the 13 species of Tungidae are only in the Western hemisphere, and each only targets 1-2 specific warm-blooded hosts.[2][4]

Seven Tunga species infest only rodents. Two dedicate themselves to armadillos, one to sloths, and another prefers only cattle. Only one, Tunga trimamillata, has also been found infesting humans as well as cows, but only in Ecuador and Peru.[5]

Host species for T. penetrans'[5]

Environment

For the most part, the chigoe flea lives 2–5 cm below sand, an observation which helps explain its overall distribution. The temperature is generally too hot for the larvae to develop on the surface of the sand and the deeper sand does not have enough oxygen.

In a study of off-host stages,[6] samples were taken from the top of the soil (to a maximum depth of 1 cm). The presence of T. penetrans in a soil sample was unaffected by soil temperature, air temperature or air humidity. No life stages of T. penetrans were found in any outdoor sample.

There is an observable drop in infestations during the wet season.[7]

Life cycle

T. penetrans eggs, on average, are 0.6 mm long, The larva will hatch from the egg within one to six days, assuming the environmental conditions (e.g., moisture, humidity, etc.) are favorable.[8]

After hatching, the flea will progress through two instar phases. This is unique in that most fleas go through three. Over the course of that development, the flea will first decrease in size from its just-hatched size of 1.5 mm to 1.15 mm (first instar) before growing to 2.9 mm (second instar).

About six to eight days after hatching, the larva pupates and builds a cocoon around itself. Because it lives mostly on and below the surface of sand, sand is used to stabilize the cocoon and help to promote its development. An environmental disturbance such as rain or a lack of sand have been shown to decrease incidence, most likely due to decreasing the environmental factors (i.e., sand) on which the flea depends for overall growth.[7] Barring any disturbances to the cocoon, an adult flea will emerge from the puparium after 9–15 days.[8]

Males are still mobile after a blood meal like other fleas, but the female flea burrows head-first into the host's skin, leaving the caudal tip of its abdomen visible through an orifice in a skin lesion. This orifice allows the flea to breathe, defecate, mate and expel eggs while feeding from blood vessels. It lives in the cutaneous and subcutaneous dermal layer.

Tungiasis lesions almost always occur on the feet (97%), but may occur on any part of the body. The toes are afflicted over 70% of the time, with periungual folds (around the toenail) a preferred site.

Only once the female burrows into the skin can reproduction occur, as the male and female show no interest in each other in the wild.[8] The male flea dies after copulation. The female flea continues in vivo development, described in stages by the Fortaleza classification of tungiasis.

Over the next two weeks, its abdomen swells with up to several hundred to a thousand eggs, which it releases through the caudal orifice to fall to the ground when ready to hatch. The flea then dies and is often the cause of infection as the body rots under the thick scales its body chemistry created to protect it. The eggs mature into adult fleas within three to four weeks and the process begins anew.

In vivo development

In a seminal paper on the biology and pathology of Tunga penetrans, Eisele et al. (2003) provided and detailed the five stages of tungiasis, thereby detailing the in vivo development of the female chigoe flea for the first time.[9] In dividing the natural history of the disease, the Fortaleza Classification formally describes the last part of the female flea's life cycle where it burrows into its host's skin, expels eggs, and dies.

Stage 1 is characterized by the penetration of the skin by the female chigoe flea. Running along the body, the female uses its posterior legs to push its body upward by an angle between 45–90 degrees. Penetration then starts, beginning with the proboscis going through the epidermis.[9]

By stage 2 (days 1–2), penetration is complete and the flea has burrowed most of its body into the skin. Only the anus, the copulatory organs, and four rear air holes in fleas called stigmata remain on the outside of the epidermis. The anus will excrete feces that is thought to attract male fleas for mating, described in a later section. The hypertrophic zone between tergites 2 and 3 in the abdominal region begins to expand a day or two after penetration and takes the appearance of a life belt. During this time, the flea begins to feed on the host's blood.[9]

Stage 3 is divided into two substages, the first of which being 2–3 days after penetration is complete. In 3a, maximum hypertrophy is achieved and the flea's midsection swells to the size of a pea.

Due to the expanding flea, the outer layer of the skin is stretched thin, resulting in the appearance of a white halo around the black dot (rear end of the flea) at the center of the lesion.[9] The black dot is the flea's exposed hind legs, respiratory spiracles and reproductive organs.[10]

In 3b, the chitin exoskeleton of tergites 2 and 3 increase in thickness and gives the structure the look of a mini caldera. Egg release is common in substage 3b, as are fecal coils. The eggs tend to stick to the skin.[9] At about the 3rd week after penetration, stage 4 begins, which is also divided into two substages. In 4a, the flea loses its signs of vitality and appears near death. As a result, the lesion shrinks in size, turns brown, and appears wrinkled. The death of the flea marks the beginning of substage 4b (around day 25 post-penetration) as the body begins to eliminate the parasite through skin repair mechanisms (e.g. shedding and subsequent skin repair). At this phase, the lesion is seen as brown or black.[9]

If the flea is left within the skin, dangerous complications can occur including secondary infections from trapped bacteria such as staph, strep, enterobacteriaceae, tetanus, etc.[11] Lingering effects may include loss of toenails and toe deformation. These seem to be commonplace especially where heavy infestations combine with unsanitary conditions and poverty.[1]

History

Tungiasis was endemic in pre-Columbian Andean society for centuries before discovery of T. penetrans as native to the West Indies.[12] The first European description was published in 1526 by Gonzalo Fernández de Oviedo y Valdés,[13] where he discussed the skin infection and its symptoms on crew members from Columbus's Santa Maria after they were shipwrecked on Haiti.[14] Through ship routes and further expeditions, the chigoe flea was spread to the rest of the world, particularly to the rest of Latin America and Africa. The spread to greater Africa occurred throughout the 17th and 19th centuries, specifically in 1872 when the infected crewmen of the ship Thomas Mitchell introduced it into Angola by dumping of sand ballast, having sailed from Brazil.[15][16]

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See also

References
  1. Cestari TF, Pessato S, Ramos-e-Silva M Tungiasis and myiasis. Clin Dermatol. 2007 Mar-Apr;25(2):158-64.
  2. Beaucournu, J.-C.; Degeilh, B.; Mergey, T.; Muñoz-Leal, S.; González-Acuña, D. (2012). "Le genre Tunga Jarocki, 1838 (Siphonaptera: Tungidae). I – Taxonomie, phylogénie, écologie, rôle pathogène". Parasite. 19 (4): 297–308. doi:10.1051/parasite/2012194297. ISSN 1252-607X. PMC 4898135. PMID 23193514.
  3. "Chiggers." About.com. 27 Feb. 2009 <http://pediatrics.about.com/od/dermatologytopics/a/06_chiggers.htm>
  4. Linardi, Pedro Marcos; Beaucournu, Jean-Claude; de Avelar, Daniel Moreira; Belaz, Sorya (2014). "Notes on the genus Tunga (Siphonaptera: Tungidae) II – neosomes, morphology, classification, and other taxonomic notes". Parasite. 21: 68. doi:10.1051/parasite/2014067. ISSN 1776-1042. PMC 4270284. PMID 25514594.
  5. Linardi, Pedro Marcos; de Avelar, Daniel Moreira (2014). "Neosomes of tungid fleas on wild and domestic animals". Parasitology Research. 113 (10): 3517–3533. doi:10.1007/s00436-014-4081-8. PMC 4172993. PMID 25141814.
  6. Linardi, P. M.; Calheiros, C. M. L.; Campelo-junior, E. B.; Duarte, E.M.; Heukelbach, J.; Feldmeier, H. (2010). "Occurrence of the off-host life stages of Tunga penetrans (Siphonaptera) in various environments in Brazil". Annals of Tropical Medicine & Parasitology. 104 (4): 337–345. doi:10.1179/136485910X12743554759902. PMID 20659395.
  7. Heukelbach, Jörg; Wilcke, Thomas; Harms, Gundel; Feldmeier, Hermann (2005). "Seasonal variation of tungiasis in an endemic community". The American Journal of Tropical Medicine and Hygiene. 72 (2): 145–9. doi:10.4269/ajtmh.2005.72.145. PMID 15741550.
  8. Nagy, N.; Abari, E.; D’Haese, J.; Calheiros, C.; Heukelbach, J.; Mencke, N.; Feldmeier, H.; Mehlhorn, H. (2007). "Investigations on the life cycle and morphology of Tunga penetrans in Brazil". Parasitology Research. 101 (Suppl 2): S233–42. doi:10.1007/s00436-007-0683-8. PMID 17823833.
  9. Eisele, Margit; Heukelbach, Jörg; Van Marck, Eric; Mehlhorn, Heinz; Meckes, Oliver; Franck, Sabine; Feldmeier, Hermann (2003). "Investigations on the biology, epidemiology, pathology and control of Tunga penetrans in Brazil: I. Natural history of tungiasis in man". Parasitology Research. 90 (2): 87–99. doi:10.1007/s00436-002-0817-y. PMID 12756541.
  10. Muehlstaedt, M (2008). "Periungual Tungiasis Images in clinical medicine". N Engl J Med. 359 (24): e30. doi:10.1056/nejmicm074290. PMID 19073971.
  11. Feldmeier H, Heukelbach J, Eisele M, Souza A, Barbosa L, Carvalho C (2002). "Bacterial superinfection in human tungiasis". Tropical Medicine & International Health. 7 (7): 559–564. doi:10.1046/j.1365-3156.2002.00904.x. PMID 12100437.
  12. Maco, V; Tantaleán, M; Gotuzzo, E (May 2011). "Evidence of tungiasis in pre-Hispanic America". Emerging Infectious Diseases. 17 (5): 855–62. doi:10.3201/eid1705.100542. PMC 3321756. PMID 21529395.
  13. Oviedo y Valdes, F. (1526). Sumario de la natural historia de las Indias. Toledo: acostas del autor: por industrias del maestre Ramon de Petras.
  14. Darmstadt GL, Francis JS (May 2000). "Tungiasis in a young child adopted from South America". Pediatr. Infect. Dis. J. 19 (5): 485–7. doi:10.1097/00006454-200005000-00024. PMID 10819355.
  15. Joseph J.; Bazile J.; Mutter J.; Shin S.; Ruddle A.; Ivers L.; Lyon E.; Farmer P. (2006). "Tungiasis in rural Haiti: a community-based response". Transactions of the Royal Society of Tropical Medicine and Hygiene. 100 (10): 970–974. doi:10.1016/j.trstmh.2005.11.006. PMID 16516941.
  16. Hoeppli R (1963). "Early references to the occurrence of Tunga penetrans in tropical Africa". Acta Trop. 20: 142–152. PMID 13963854.
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