Trifunctional purine biosynthetic protein adenosine-3

Trifunctional purine biosynthetic protein adenosine-3 is an enzyme that in humans is encoded by the GART gene.[5]

GART
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesGART, AIRS, GARS, GARTF, PAIS, PGFT, PRGS, phosphoribosylglycinamide formyltransferase, phosphoribosylglycinamide synthetase, phosphoribosylaminoimidazole synthetase
External IDsOMIM: 138440 MGI: 95654 HomoloGene: 637 GeneCards: GART
Gene location (Human)
Chr.Chromosome 21 (human)[1]
Band21q22.11Start33,503,931 bp[1]
End33,543,491 bp[1]
Orthologs
SpeciesHumanMouse
Entrez

2618

14450

Ensembl

ENSG00000262473
ENSG00000159131

ENSMUSG00000022962

UniProt

P22102

Q64737

RefSeq (mRNA)

NM_000819
NM_001136005
NM_001136006
NM_175085

NM_010256
NM_001357351

RefSeq (protein)

NP_000810
NP_001129477
NP_001129478
NP_780294

NP_034386
NP_001344280

Location (UCSC)Chr 21: 33.5 – 33.54 MbChr 16: 91.62 – 91.65 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

This protein is a trifunctional polypeptide. It has Phosphoribosylamine—glycine ligase (EC 6.3.4.13), Phosphoribosylglycinamide formyltransferase (EC 2.1.2.2), AIR synthetase (FGAM cyclase) (EC 6.3.3.1) activity which is required for de novo purine biosynthesis.

References

  1. ENSG00000159131 GRCh38: Ensembl release 89: ENSG00000262473, ENSG00000159131 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000022962 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Gnirke A, Barnes TS, Patterson D, Schild D, Featherstone T, Olson MV (July 1991). "Cloning and in vivo expression of the human GART gene using yeast artificial chromosomes". EMBO J. 10 (7): 1629–34. PMC 452831. PMID 2050105.

Further reading


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