Tombusvirus internal replication element (IRE)
In virology, the tombusvirus internal replication element (IRE) is a segment of RNA located within the region coding for p92 polymerase. This element is essential for viral replication; specifically, it is thought to be required at an early stage of replication, such as template recruitment and/or replicase complex assembly.[1]
| Tombusvirus internal replication element (IRE) | |
|---|---|
 Predicted secondary structure and sequence conservation of Tombus_IRE | |
| Identifiers | |
| Symbol | Tombus_IRE |
| Rfam | RF00510 |
| Other data | |
| RNA type | Cis-reg |
| Domain(s) | Viruses |
| SO | 0000233 |
| PDB structures | PDBe |
Other non-coding RNA structures in Tombusvirus include the 3' UTR region IV[2] and 5' UTR.[3][4]
References
- Monkewich, S; Lin HX; Fabian MR; Xu W; Na H; Ray D; Chernysheva OA; Nagy PD; White KA (2005). "The p92 Polymerase Coding Region Contains an Internal RNA Element Required at an Early Step in Tombusvirus Genome Replication". J Virol. 79 (8): 4848–4858. doi:10.1128/JVI.79.8.4848-4858.2005. PMC 1069561. PMID 15795270.
- Fabian MR, Na H, Ray D, White KA (2003). "3'-Terminal RNA secondary structures are important for accumulation of tomato bushy stunt virus DI RNAs". Virology. 313 (2): 567–580. doi:10.1016/S0042-6822(03)00349-0. PMID 12954222.
- Wu B, Vanti WB, White KA (2001). "An RNA domain within the 5' untranslated region of the tomato bushy stunt virus genome modulates viral RNA replication". J. Mol. Biol. 305 (4): 741–756. doi:10.1006/jmbi.2000.4298. PMID 11162089.
- Ray D, Na H, White KA (2004). "Structural properties of a multifunctional T-shaped RNA domain that mediate efficient tomato bushy stunt virus RNA replication". J. Virol. 78 (19): 10490–10500. doi:10.1128/JVI.78.19.10490-10500.2004. PMC 516415. PMID 15367615.
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