Thyroglobulin domain
Thyroglobulin type-1 repeat is an evolutionary conserved protein domain. Thyroglobulin type 1 repeats are thought to be involved in the control of proteolytic degradation. The domain usually contains six conserved cysteines. These form three disulphide bridges. Cysteines 1 pairs with 2, 3 with 4 and 5 with 6.
| Thyroglobulin type-1 repeat | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
 Thyroglobulin type-1 domain | |||||||||||
| Identifiers | |||||||||||
| Symbol | Thyroglobulin_1 | ||||||||||
| Pfam | PF00086 | ||||||||||
| InterPro | IPR000716 | ||||||||||
| PROSITE | PDOC00377 | ||||||||||
| SCOPe | 1icf / SUPFAM | ||||||||||
| CDD | cd00191 | ||||||||||
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Human proteins containing this domain
CD74; IGFBP-4; IGFBP1; IGFBP2; IGFBP3; IGFBP4; IGFBP5; IGFBP6; NID1; NID2; SMOC1; SMOC2; SPOCK1; SPOCK2; SPOCK3; TACSTD1; TACSTD2; TG;
gollark: That's actually beyond your comprehension, given your exposure to certain other cognitohazards in the past.
gollark: Well, it doesn't do much, it's not particularly dangerous.
gollark: Oh, you meant THAT giant cognitohazard, yes.
gollark: You don't really have it under very good surveillance, considering.
gollark: Oh. Maybe your coordinates were just wrong.
References
- Guncar G, Pungercic G, Klemencic I, Turk V, Turk D (February 1999). "Crystal structure of MHC class II-associated p41 Ii fragment bound to cathepsin L reveals the structural basis for differentiation between cathepsins L and S". The EMBO Journal. 18 (4): 793–803. doi:10.1093/emboj/18.4.793. PMC 1171172. PMID 10022822.
- Molina F, Bouanani M, Pau B, Granier C (August 1996). "Characterization of the type-1 repeat from thyroglobulin, a cysteine-rich module found in proteins from different families". European Journal of Biochemistry. 240 (1): 125–33. doi:10.1111/j.1432-1033.1996.0125h.x. PMID 8797845.
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