SPOCK2

Testican-2 is a protein that in humans is encoded by the SPOCK2 gene.[5][6]

SPOCK2
Identifiers
Aliases	SPOCK2, testican-2, sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 2, SPARC/osteonectin, cwcv and kazal like domains proteoglycan 2, SPARC (osteonectin), cwcv and kazal like domains proteoglycan 2
External IDs	OMIM: 607988 MGI: 1891351 HomoloGene: 8854 GeneCards: SPOCK2
Gene location (Human) Chr. Chromosome 10 (human)[1] Band 10q22.1 Start 72,059,034 bp[1] End 72,089,032 bp[1]
Gene location (Mouse) Chr. Chromosome 10 (mouse)[2] Band 10|10 B4 Start 60,106,219 bp[2] End 60,135,198 bp[2]
RNA expression pattern More reference expression data
Gene ontology Molecular function • calcium ion binding • glycosaminoglycan binding • extracellular matrix binding • metalloendopeptidase inhibitor activity • collagen binding Cellular component • extracellular region • extracellular matrix • extracellular Biological process • regulation of cell differentiation • synapse assembly • peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan • extracellular matrix organization • signal transduction • positive regulation of cell-substrate adhesion • negative regulation of endopeptidase activity • positive regulation of cell motility • cellular response to leukemia inhibitory factor Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	9806	94214
Ensembl	ENSG00000107742	ENSMUSG00000058297
UniProt	Q92563	Q9ER58
RefSeq (mRNA)	NM_001134434 NM_001244950 NM_014767	NM_052994
RefSeq (protein)	NP_001127906 NP_001231879 NP_055582	NP_443720
Location (UCSC)	Chr 10: 72.06 – 72.09 Mb	Chr 10: 60.11 – 60.14 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

Function

Proteoglycans, which consist of a core protein and covalently linked glycosaminoglycans, are components of the extracellular matrix. SPOCK2 encodes a member of a novel Ca(2+)-binding proteoglycan family.[supplied by OMIM][6]

References

1. GRCh38: Ensembl release 89: ENSG00000107742 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000058297 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Vannahme C, Schübel S, Herud M, Gösling S, Hülsmann H, Paulsson M, Hartmann U, Maurer P (July 1999). "Molecular cloning of testican-2: defining a novel calcium-binding proteoglycan family expressed in brain". Journal of Neurochemistry. 73 (1): 12–20. doi:10.1046/j.1471-4159.1999.0730012.x. PMID 10386950.
6. "Entrez Gene: SPOCK2 sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 2".

Further reading

• Nagase T, Seki N, Ishikawa K, Ohira M, Kawarabayasi Y, Ohara O, Tanaka A, Kotani H, Miyajima N, Nomura N (October 1996). "Prediction of the coding sequences of unidentified human genes. VI. The coding sequences of 80 new genes (KIAA0201-KIAA0280) deduced by analysis of cDNA clones from cell line KG-1 and brain". DNA Research. 3 (5): 321–9, 341–54. doi:10.1093/dnares/3.5.321. PMID 9039502.
• Nakayama M, Kikuno R, Ohara O (November 2002). "Protein-protein interactions between large proteins: two-hybrid screening using a functionally classified library composed of long cDNAs". Genome Research. 12 (11): 1773–84. doi:10.1101/gr.406902. PMC 187542. PMID 12421765.
• Nakada M, Miyamori H, Yamashita J, Sato H (June 2003). "Testican 2 abrogates inhibition of membrane-type matrix metalloproteinases by other testican family proteins". Cancer Research. 63 (12): 3364–9. PMID 12810672.
• Clark HF, Gurney AL, Abaya E, Baker K, Baldwin D, Brush J, Chen J, Chow B, Chui C, Crowley C, Currell B, Deuel B, Dowd P, Eaton D, Foster J, Grimaldi C, Gu Q, Hass PE, Heldens S, Huang A, Kim HS, Klimowski L, Jin Y, Johnson S, Lee J, Lewis L, Liao D, Mark M, Robbie E, Sanchez C, Schoenfeld J, Seshagiri S, Simmons L, Singh J, Smith V, Stinson J, Vagts A, Vandlen R, Watanabe C, Wieand D, Woods K, Xie MH, Yansura D, Yi S, Yu G, Yuan J, Zhang M, Zhang Z, Goddard A, Wood WI, Godowski P, Gray A (October 2003). "The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment". Genome Research. 13 (10): 2265–70. doi:10.1101/gr.1293003. PMC 403697. PMID 12975309.
• Zhang Z, Henzel WJ (October 2004). "Signal peptide prediction based on analysis of experimentally verified cleavage sites". Protein Science. 13 (10): 2819–24. doi:10.1110/ps.04682504. PMC 2286551. PMID 15340161.
• Olsen JV, Blagoev B, Gnad F, Macek B, Kumar C, Mortensen P, Mann M (November 2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983.