The AIM center

The Autophagy, Inflammation and Metabolism (AIM) center[1][2] is an NIH-funded[3] Center of Biomedical Research Excellence focused on the study of autophagy as a fundamental biological process and how it intersects with metabolism and quality control processes in eukaryotic cells. A special emphasis is on the role or autophagy in a wide spectrum of diseases with me[4] tabolic, inflammatory and immunological aspects. At the fundamental level, autophagy is a cytoplasmic pathway for the disposal of damaged or surplus organelles such as mitochondria, peroxisomes, lysosomes, endoplasmic reticulum, ribosomes, protein aggregates and also serves as a catabolic process providing nutrients through autodigestion at times of starvation. Autophagy has been implicated in cancer, neurodegeneration such as Alzheimer's disease, Huntington's disease and Parkinson's disease, diabetes, development, infections and immune diseases, as well as a process of relevance for aging.

The purpose of the AIM center is to promote autophagy research at the international, national and regional levels and to provide resources to communities of scholars interested in this process in any context including basic science or translational research. AIM has scientific cores providing technical resources for study of autophagy, accessible to its members, associate members as well as to a group of international affiliate members. It provides a mentoring structure for support of junior faculty enrolled with the center and promotes collaborative multidisciplinary studies centered on the key thematic focus of the AIM center – fundamental study of autophagy and its role in disease. The AIM has International Council of Affiliate Members (ICAM) on all continents.[2] The ICAM is complemented by the National Council of Affiliate (NCAM) members. NCAM is organized in sections by clinical disciplines/specialties, and at present has cardiology and nephrology sections.

The center hosts annual meetings and workshops with national and international reach and impact.

The AIM center leads and supports cutting edge research, including supporting research pilots https://www.autophagy.center/node/443 for Covid / coronavirus pandemic crisis.

The AIM center is hosting together with the Journal of Cell Science the 2020 international AIM eSymposium on covid, autophagy, inflammation and metabolism.

AIM center primary publications and reviews include a variety of articles from mentored principal investigators and senior members of the AIM center, by year: 2020;[5][6][7][8][9][10][11][12][13][14][15][16][17][18][19][20][21][22] 2019;[23][24][25][26][27][28][29][30][31][32][33][34] 2018:.[35][36][37][38][39][40][41][42][43][44][45][46][47][48]

References
  1. Deretic V, Prossnitz E, Burge M, Campen MJ, Cannon J, Liu KJ, et al. (2018-06-23). "Autophagy, Inflammation, and Metabolism (AIM) Center of Biomedical Research Excellence: supporting the next generation of autophagy researchers and fostering international collaborations". Autophagy. 14 (6): 925–929. doi:10.1080/15548627.2018.1465784. PMID 29938597.
  2. Deretic V, Prossnitz E, Burge M, Campen MJ, Cannon J, Liu KJ, et al. (October 2019). "Autophagy, Inflammation, and Metabolism (AIM) Center in its second year". Autophagy. 15 (10): 1829–1833. doi:10.1080/15548627.2019.1634444. PMC 6735631. PMID 31234750.
  3. Vojo D. "Autophagy, Inflammation and Metabolism (AIM) in Disease Center". Grantome.
  4. Kehl, Stephanie R.; Soos, Brandy-Lee A.; Saha, Bhaskar; Choi, Seong Won; Herren, Anthony W.; Johansen, Terje; Mandell, Michael A. (September 2019). "TAK1 converts Sequestosome 1/p62 from an autophagy receptor to a signaling platform". EMBO reports. 20 (9): e46238. doi:10.15252/embr.201846238. ISSN 1469-3178. PMC 6726904. PMID 31347268.
  5. Sharma, Geetanjali; Hu, Chelin; Staquicini, Daniela I.; Brigman, Jonathan L.; Liu, Meilian; Mauvais-Jarvis, Franck; Pasqualini, Renata; Arap, Wadih; Arterburn, Jeffrey B.; Hathaway, Helen J.; Prossnitz, Eric R. (29 January 2020). "Preclinical efficacy of the GPER-selective agonist G-1 in mouse models of obesity and diabetes". Science Translational Medicine. 12 (528). doi:10.1126/scitranslmed.aau5956. ISSN 1946-6242. PMC 7083206. PMID 31996464.
  6. Kumar, Suresh; Jain, Ashish; Choi, Seong Won; da Silva, Gustavo Peixoto Duarte; Allers, Lee; Mudd, Michal H.; Peters, Ryan Scott; Anonsen, Jan Haug; Rusten, Tor-Erik; Lazarou, Michael; Deretic, Vojo (August 2020). "Mammalian Atg8 proteins and the autophagy factor IRGM control mTOR and TFEB at a regulatory node critical for responses to pathogens". Nature Cell Biology. 22 (8): 973–985. doi:10.1038/s41556-020-0549-1. ISSN 1465-7392.
  7. Joyner, Jason A.; Daly, Seth M.; Peabody, Julianne; Triplett, Kathleen D.; Pokhrel, Srijana; Elmore, Bradley O.; Adebanjo, Diane; Peabody, David S.; Chackerian, Bryce; Hall, Pamela R. (2020-07-11). "Vaccination with VLPs Presenting a Linear Neutralizing Domain of S. aureus Hla Elicits Protective Immunity". Toxins. 12 (7). doi:10.3390/toxins12070450. ISSN 2072-6651. PMID 32664481.
  8. Brandenburg, Jacquelyn S.; Clark, Ross M.; Coffman, Brittany; Sharma, Geetanjali; Hathaway, Helen J.; Prossnitz, Eric R.; Howdieshell, Thomas R. (July 2020). "Sex differences in murine myocutaneous flap revascularization". Wound Repair and Regeneration: Official Publication of the Wound Healing Society [and] the European Tissue Repair Society. 28 (4): 470–479. doi:10.1111/wrr.12812. ISSN 1524-475X. PMID 32428975.
  9. Binder, Jessica L.; Chander, Praveen; Deretic, Vojo; Weick, Jason P.; Bhaskar, Kiran (2020). "Optical induction of autophagy via Transcription factor EB (TFEB) reduces pathological tau in neurons". PloS One. 15 (3): e0230026. doi:10.1371/journal.pone.0230026. ISSN 1932-6203. PMC 7092971. PMID 32208437.
  10. Zhou, Zhangsen; Torres, Mauricio; Sha, Haibo; Halbrook, Christopher J.; Van den Bergh, Françoise; Reinert, Rachel B.; Yamada, Tatsuya; Wang, Siwen; Luo, Yingying; Hunter, Allen H.; Wang, Chunqing (3 April 2020). "Endoplasmic reticulum-associated degradation regulates mitochondrial dynamics in brown adipocytes". Science (New York, N.Y.). 368 (6486): 54–60. doi:10.1126/science.aay2494. ISSN 1095-9203. PMC 7409365. PMID 32193362.
  11. Molenaars, Marte; Janssens, Georges E.; Williams, Evan G.; Jongejan, Aldo; Lan, Jiayi; Rabot, Sylvie; Joly, Fatima; Moerland, Perry D.; Schomakers, Bauke V.; Lezzerini, Marco; Liu, Yasmine J. (2020-03-03). "A Conserved Mito-Cytosolic Translational Balance Links Two Longevity Pathways". Cell Metabolism. 31 (3): 549–563.e7. doi:10.1016/j.cmet.2020.01.011. ISSN 1932-7420. PMC 7214782. PMID 32084377.
  12. Jia, Jingyue; Bissa, Bhawana; Brecht, Lukas; Allers, Lee; Choi, Seong Won; Gu, Yuexi; Zbinden, Mark; Burge, Mark R.; Timmins, Graham; Hallows, Kenneth; Behrends, Christian (5 March 2020). "AMPK, a Regulator of Metabolism and Autophagy, Is Activated by Lysosomal Damage via a Novel Galectin-Directed Ubiquitin Signal Transduction System". Molecular Cell. 77 (5): 951–969.e9. doi:10.1016/j.molcel.2019.12.028. ISSN 1097-4164. PMID 31995728.
  13. Zimmerman, Amber J.; Hafez, Alexander K.; Amoah, Stephen K.; Rodriguez, Brian A.; Dell'Orco, Michela; Lozano, Evelyn; Hartley, Brigham J.; Alural, Begüm; Lalonde, Jasmin; Chander, Praveen; Webster, Maree J. (2020-01-27). "A psychiatric disease-related circular RNA controls synaptic gene expression and cognition". Molecular Psychiatry. doi:10.1038/s41380-020-0653-4. ISSN 1476-5578. PMID 31988434.
  14. Jia, Jingyue; Bissa, Bhawana; Brecht, Lukas; Allers, Lee; Choi, Seong Won; Gu, Yuexi; Zbinden, Mark; Burge, Mark R.; Timmins, Graham; Hallows, Kenneth; Behrends, Christian (2020-08-02). "AMPK is activated during lysosomal damage via a galectin-ubiquitin signal transduction system". Autophagy. 16 (8): 1550–1552. doi:10.1080/15548627.2020.1788890. ISSN 1554-8627.
  15. Jia, Jingyue; Claude-Taupin, Aurore; Gu, Yuexi; Choi, Seong Won; Peters, Ryan; Bissa, Bhawana; Mudd, Michal H.; Allers, Lee; Pallikkuth, Sandeep; Lidke, Keith A.; Salemi, Michelle (2020-08-02). "MERIT, a cellular system coordinating lysosomal repair, removal and replacement". Autophagy. 16 (8): 1539–1541. doi:10.1080/15548627.2020.1779451. ISSN 1554-8627.
  16. Zhang, Xing; Wu, Dandan; Wang, Chunqing; Luo, Yan; Ding, Xiaofeng; Yang, Xin; Silva, Floyd; Arenas, Sara; Weaver, John Michael; Mandell, Michael; Deretic, Vojo (2019-12-18). "Sustained activation of autophagy suppresses adipocyte maturation via a lipolysis-dependent mechanism". Autophagy: 1–15. doi:10.1080/15548627.2019.1703355. ISSN 1554-8635. PMID 31840569.
  17. Jia, Jingyue; Claude-Taupin, Aurore; Gu, Yuexi; Choi, Seong Won; Peters, Ryan; Bissa, Bhawana; Mudd, Michal H.; Allers, Lee; Pallikkuth, Sandeep; Lidke, Keith A.; Salemi, Michelle (6 January 2020). "Galectin-3 Coordinates a Cellular System for Lysosomal Repair and Removal". Developmental Cell. 52 (1): 69–87.e8. doi:10.1016/j.devcel.2019.10.025. ISSN 1878-1551. PMC 6997950. PMID 31813797.
  18. Barton, Matthias; Prossnitz, Eric R. (February 2020). "Early life stress determines insulin signalling in adulthood". The Journal of Physiology. 598 (3): 427–428. doi:10.1113/JP279300. ISSN 1469-7793. PMC 6996920. PMID 31785103.
  19. Zheng, Handong; Wu, Xiang; Wu, Dandan; Jiang, Ruo-Lan; Castillo, Eliseo F.; Chock, Cameron J.; Zhou, Qin; Liu, Meilian; Dong, Chen; Yang, Xuexian O. (March 2020). "Treg expression of CIS suppresses allergic airway inflammation through antagonizing an autonomous TH2 program". Mucosal Immunology. 13 (2): 293–302. doi:10.1038/s41385-019-0236-3. ISSN 1935-3456. PMC 7044046. PMID 31780776.
  20. Amoah, Stephen K.; Rodriguez, Brian A.; Logothetis, Constantine N.; Chander, Praveen; Sellgren, Carl M.; Weick, Jason P.; Sheridan, Steven D.; Jantzie, Lauren L.; Webster, Maree J.; Mellios, Nikolaos (March 2020). "Exosomal secretion of a psychosis-altered miRNA that regulates glutamate receptor expression is affected by antipsychotics". Neuropsychopharmacology: Official Publication of the American College of Neuropsychopharmacology. 45 (4): 656–665. doi:10.1038/s41386-019-0579-1. ISSN 1740-634X. PMC 7021900. PMID 31775160.
  21. Zou, Ke; Rouskin, Silvia; Dervishi, Kevin; McCormick, Mark A.; Sasikumar, Arjun; Deng, Changhui; Chen, Zhibing; Kaeberlein, Matt; Brem, Rachel B.; Polymenis, Michael; Kennedy, Brian K. (August 2020). "Life span extension by glucose restriction is abrogated by methionine supplementation: Cross-talk between glucose and methionine and implication of methionine as a key regulator of life span". Science Advances. 6 (32): eaba1306. doi:10.1126/sciadv.aba1306. ISSN 2375-2548.
  22. Felker, Daniel P.; Robbins, Christine E.; McCormick, Mark A. (2020). "Automation of C. elegans lifespan measurement". Translational Medicine of Aging. 4: 1–10. doi:10.1016/j.tma.2019.12.001.
  23. Revankar, Chetana M.; Bologa, Cristian G.; Pepermans, Richard A.; Sharma, Geetanjali; Petrie, Whitney K.; Alcon, Sara N.; Field, Angela S.; Ramesh, Chinnasamy; Parker, Matthew A.; Savchuk, Nikolay P.; Sklar, Larry A. (19 December 2019). "A Selective Ligand for Estrogen Receptor Proteins Discriminates Rapid and Genomic Signaling". Cell Chemical Biology. 26 (12): 1692–1702.e5. doi:10.1016/j.chembiol.2019.10.009. ISSN 2451-9448. PMC 6925632. PMID 31706983.
  24. Overå, Katrine Stange; Garcia-Garcia, Juncal; Bhujabal, Zambarlal; Jain, Ashish; Øvervatn, Aud; Larsen, Kenneth Bowitz; Deretic, Vojo; Johansen, Terje; Lamark, Trond; Sjøttem, Eva (2 December 2019). "TRIM32, but not its muscular dystrophy-associated mutant, positively regulates and is targeted to autophagic degradation by p62/SQSTM1". Journal of Cell Science. 132 (23). doi:10.1242/jcs.236596. ISSN 1477-9137. PMC 6918758. PMID 31685529.
  25. Gu, Yuexi; Princely Abudu, Yakubu; Kumar, Suresh; Bissa, Bhawana; Choi, Seong Won; Jia, Jingyue; Lazarou, Michael; Eskelinen, Eeva-Liisa; Johansen, Terje; Deretic, Vojo (15 November 2019). "Mammalian Atg8 proteins regulate lysosome and autolysosome biogenesis through SNAREs". The EMBO journal. 38 (22): e101994. doi:10.15252/embj.2019101994. ISSN 1460-2075. PMC 6856626. PMID 31625181.
  26. Pepermans, Richard A.; Prossnitz, Eric R. (December 2019). "ERα-targeted endocrine therapy, resistance and the role of GPER". Steroids. 152: 108493. doi:10.1016/j.steroids.2019.108493. ISSN 1878-5867. PMC 6859199. PMID 31518595.
  27. Barton, Matthias; Meyer, Matthias R.; Prossnitz, Eric R. (December 2019). "Nox1 downregulators: A new class of therapeutics". Steroids. 152: 108494. doi:10.1016/j.steroids.2019.108494. ISSN 1878-5867. PMC 6891104. PMID 31518594.
  28. Jacenik, Damian; Beswick, Ellen J.; Krajewska, Wanda M.; Prossnitz, Eric R. (2019-08-14). "G protein-coupled estrogen receptor in colon function, immune regulation and carcinogenesis". World Journal of Gastroenterology. 25 (30): 4092–4104. doi:10.3748/wjg.v25.i30.4092. ISSN 2219-2840. PMC 6700692. PMID 31435166.
  29. Moses, Melanie E.; Cannon, Judy L.; Gordon, Deborah M.; Forrest, Stephanie (2019). "Distributed Adaptive Search in T Cells: Lessons From Ants". Frontiers in Immunology. 10: 1357. doi:10.3389/fimmu.2019.01357. ISSN 1664-3224. PMC 6585175. PMID 31263465.
  30. Perez, Dominique R.; Sklar, Larry A.; Chigaev, Alexandre (July 2019). "Clioquinol: To harm or heal". Pharmacology & Therapeutics. 199: 155–163. doi:10.1016/j.pharmthera.2019.03.009. ISSN 1879-016X. PMC 6571072. PMID 30898518.
  31. Wong, Morgan; Ganapathy, Ashwinkumar Subramenium; Suchanec, Eric; Laidler, Laura; Ma, Thomas; Nighot, Prashant (1 May 2019). "Intestinal epithelial tight junction barrier regulation by autophagy-related protein ATG6/beclin 1". American Journal of Physiology. Cell Physiology. 316 (5): C753–C765. doi:10.1152/ajpcell.00246.2018. ISSN 1522-1563. PMC 6580157. PMID 30892937.
  32. Kumar, Suresh; Gu, Yuexi; Abudu, Yakubu Princely; Bruun, Jack-Ansgar; Jain, Ashish; Farzam, Farzin; Mudd, Michal; Anonsen, Jan Haug; Rusten, Tor Erik; Kasof, Gary; Ktistakis, Nicholas (8 April 2019). "Phosphorylation of Syntaxin 17 by TBK1 Controls Autophagy Initiation". Developmental Cell. 49 (1): 130–144.e6. doi:10.1016/j.devcel.2019.01.027. ISSN 1878-1551. PMC 6907693. PMID 30827897.
  33. Deretic, Vojo; Timmins, Graham S. (March 2019). "Enhancement of lung levels of antibiotics by ambroxol and bromhexine". Expert Opinion on Drug Metabolism & Toxicology. 15 (3): 213–218. doi:10.1080/17425255.2019.1578748. ISSN 1744-7607. PMC 6947664. PMID 30721101.
  34. Triplett, Kathleen D.; Pokhrel, Srijana; Castleman, Moriah J.; Daly, Seth M.; Elmore, Bradley O.; Joyner, Jason A.; Sharma, Geetanjali; Herbert, Guy; Campen, Matthew J.; Hathaway, Helen J.; Prossnitz, Eric R. (4 February 2019). "GPER activation protects against epithelial barrier disruption by Staphylococcus aureus α-toxin". Scientific Reports. 9 (1): 1343. doi:10.1038/s41598-018-37951-3. ISSN 2045-2322. PMC 6362070. PMID 30718654.
  35. Merkley, Seth D.; Chock, Cameron J.; Yang, Xuexian O.; Harris, James; Castillo, Eliseo F. (2018). "Modulating T Cell Responses via Autophagy: The Intrinsic Influence Controlling the Function of Both Antigen-Presenting Cells and T Cells". Frontiers in Immunology. 9: 2914. doi:10.3389/fimmu.2018.02914. ISSN 1664-3224. PMC 6302218. PMID 30619278.
  36. Zhang, Xing; Luo, Yan; Wang, Chunqing; Ding, Xiaofeng; Yang, Xin; Wu, Dandan; Silva, Floyd; Yang, Zijiang; Zhou, Qin; Wang, Lu; Wang, Xiaoqing (18 September 2018). "Adipose mTORC1 Suppresses Prostaglandin Signaling and Beige Adipogenesis via the CRTC2-COX-2 Pathway". Cell Reports. 24 (12): 3180–3193. doi:10.1016/j.celrep.2018.08.055. ISSN 2211-1247. PMC 6287973. PMID 30232001.
  37. Tasnim, Humayra; Fricke, G. Matthew; Byrum, Janie R.; Sotiris, Justyna O.; Cannon, Judy L.; Moses, Melanie E. (2018). "Quantitative Measurement of Naïve T Cell Association With Dendritic Cells, FRCs, and Blood Vessels in Lymph Nodes". Frontiers in Immunology. 9: 1571. doi:10.3389/fimmu.2018.01571. ISSN 1664-3224. PMC 6070610. PMID 30093900.
  38. Jia, Jingyue; Abudu, Yakubu Princely; Claude-Taupin, Aurore; Gu, Yuexi; Kumar, Suresh; Choi, Seong Won; Peters, Ryan; Mudd, Michal H.; Allers, Lee; Salemi, Michelle; Phinney, Brett (January 2019). "Galectins control MTOR and AMPK in response to lysosomal damage to induce autophagy". Autophagy. 15 (1): 169–171. doi:10.1080/15548627.2018.1505155. ISSN 1554-8635. PMC 6287685. PMID 30081722.
  39. Choi, Seong Won; Gu, Yuexi; Peters, Ryan Scott; Salgame, Padmini; Ellner, Jerrold J.; Timmins, Graham S.; Deretic, Vojo (September 2018). "Ambroxol Induces Autophagy and Potentiates Rifampin Antimycobacterial Activity". Antimicrobial Agents and Chemotherapy. 62 (9). doi:10.1128/AAC.01019-18. ISSN 1098-6596. PMC 6125555. PMID 30012752.
  40. Zheng, Handong; Wu, Dandan; Wu, Xiang; Zhang, Xing; Zhou, Qin; Luo, Yan; Yang, Xin; Chock, Cameron J.; Liu, Meilian; Yang, Xuexian O. (11 June 2018). "Leptin Promotes Allergic Airway Inflammation through Targeting the Unfolded Protein Response Pathway". Scientific Reports. 8 (1): 8905. doi:10.1038/s41598-018-27278-4. ISSN 2045-2322. PMC 5995879. PMID 29891850.
  41. Bissa, Bhawana; Deretic, Vojo (23 April 2018). "Autophagosome Formation: Cutting the Gordian Knot at the ER". Current biology: CB. 28 (8): R347–R349. doi:10.1016/j.cub.2018.03.015. ISSN 1879-0445. PMID 29689207.
  42. Jia, Jingyue; Abudu, Yakubu Princely; Claude-Taupin, Aurore; Gu, Yuexi; Kumar, Suresh; Choi, Seong Won; Peters, Ryan; Mudd, Michal H.; Allers, Lee; Salemi, Michelle; Phinney, Brett (5 April 2018). "Galectins Control mTOR in Response to Endomembrane Damage". Molecular Cell. 70 (1): 120–135.e8. doi:10.1016/j.molcel.2018.03.009. ISSN 1097-4164. PMC 5911935. PMID 29625033.
  43. Claude-Taupin, Aurore; Bissa, Bhawana; Jia, Jingyue; Gu, Yuexi; Deretic, Vojo (November 2018). "Role of autophagy in IL-1β export and release from cells". Seminars in Cell & Developmental Biology. 83: 36–41. doi:10.1016/j.semcdb.2018.03.012. ISSN 1096-3634. PMC 6173661. PMID 29580970.
  44. Kumar, Suresh; Jain, Ashish; Farzam, Farzin; Jia, Jingyue; Gu, Yuexi; Choi, Seong Won; Mudd, Michal H.; Claude-Taupin, Aurore; Wester, Michael J.; Lidke, Keith A.; Rusten, Tor-Erik (5 March 2018). "Mechanism of Stx17 recruitment to autophagosomes via IRGM and mammalian Atg8 proteins". The Journal of Cell Biology. 217 (3): 997–1013. doi:10.1083/jcb.201708039. ISSN 1540-8140. PMC 5839791. PMID 29420192.
  45. Deretic, Vojo; Klionsky, Daniel J. (February 2018). "Autophagy and inflammation: A special review issue". Autophagy. 14 (2): 179–180. doi:10.1080/15548627.2017.1412229. ISSN 1554-8627. PMC 5902244. PMID 29304718.
  46. Claude-Taupin, Aurore; Jia, Jingyue; Mudd, Michal; Deretic, Vojo (2017-12-12). Lane, Jon D.; Korolchuk, Viktor I.; Murray, James T. (eds.). "Autophagy's secret life: secretion instead of degradation". Essays in Biochemistry. 61 (6): 637–647. doi:10.1042/EBC20170024. ISSN 0071-1365.
  47. Castillo, Eliseo F.; Zheng, Handong; Yang, Xuexian O. (February 2018). "Orchestration of epithelial-derived cytokines and innate immune cells in allergic airway inflammation". Cytokine & Growth Factor Reviews. 39: 19–25. doi:10.1016/j.cytogfr.2017.11.004. ISSN 1879-0305. PMC 5866749. PMID 29169815.
  48. Deretic, Vojo; Levine, Beth (2018). "Autophagy balances inflammation in innate immunity". Autophagy. 14 (2): 243–251. doi:10.1080/15548627.2017.1402992. ISSN 1554-8635. PMC 5902214. PMID 29165043.

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