Tara Keck

Tara Keck is an American-British neuroscientist and Professor of Neuroscience and Wellcome Trust Senior Research Fellow, at University College London working in the Department of Neuroscience, Physiology, and Pharmacology. She studies experience-dependent synaptic plasticity and its effect on behaviour.[1]

Tara Keck
Scientific career
Fields
  • Neuroscience
  • Physiology
  • Pharmacology
InstitutionsProfessor of Neuroscience at University College London
Websiteiris.ucl.ac.uk

Education

Professor Keck attended Harvard University from 1997 to 2001, majoring in bioengineering and then earned a PhD in biomedical engineering from Boston University in 2005, working with John White. She grew up in Erie, Pennsylvania and attended Fairview High School.

Career

Professor Keck completed her postdoctoral research at the Max Planck Institute of Neurobiology in Munich, Germany with Tobias Bonhoeffer and Mark Huebener. She received the MRC Career Development Fellowship from the Medical Research Council (United Kingdom) in 2010[2] and subsequently started her own lab at King's College London in the MRC Centre for Developmental Neurobiology[3]. In 2014, she moved her lab to University College London[4]. In 2018, she was awarded a Senior Research Fellowship from the Wellcome Trust. Professor Keck's work focuses on different forms of synaptic plasticity in the intact brain, with a focus on homeostatic plasticity. She is a recipient of the Royal Society Wolfson Research Merit Award and the Wekerle Foundation Award[5], and was a finalist for the Max Planck Society Neuroscience Research Award.

Works
  • Epilepsy in small-world networks (2004)[6]
  • Frequency-dependent glycinergic inhibition modulates plasticity in hippocampus (2008)[7]
  • Cre-dependent Expression of Multiple Transgenes in Isolated Neurons of the Adult Forebrain (2008)[8]
  • Massive restructuring of neuronal circuits during functional reorganization of adult visual cortex (2008)[9]
  • Glycinergic inhibition in the hippocampus (2009)[10]
  • Long-term, high-resolution imaging in the mouse neocortex through a chronic cranial window (2009)[11]
  • Molecular and electrophysiological characterization of GFP-expressing CA1 interneurons in GAD65-GFP mice (2010)[12]
  • Loss of sensory input causes rapid structural changes of inhibitory neurons in adult mouse visual cortex (2011)[13]
  • Three dimensional imaging of the unsectioned adult spinal cord to assess axon regeneration and glial responses after injury (2011)[14]
  • Synaptic scaling and homeostatic plasticity in the mouse visual cortex in vivo (2013)[15]
  • Imaging neuronal populations in behaving rodents: paradigms for studying neural circuits underlying behavior in the mammalian cortex (2013)[16]
  • Nonlinear transfer of signal and noise correlations in cortical networks (2015)[17]
  • Subnetwork-specific homeostatic plasticity in mouse visual cortex (2015)[18]
  • Adult plasticity and cortical reorganization after peripheral lesions (2015)[19]
  • Integrating Hebbian and homeostatic plasticity: the current state of the field and future research directions (2017)[20]
  • Interactions between synaptic homeostatic mechanisms: an attempt to reconcile BCM theory, synaptic scaling and excitation/inhibition balance (2017)[21]
  • Deprivation induced homeostatic spine scaling in vivo is spatially localized to dendritic branches that have undergone recent spine loss (2017)[22]
gollark: It is afternoon, apiomurohazard.
gollark: Night night? It's not night, apioform.
gollark: ddg! goosemod
gollark: +>markov
gollark: ddg! heavserver

References
  1. "keck-tara". www.ucl.ac.uk. 22 June 2017.
  2. "MRC Career Development Award - Research Portal, King's College, London". kclpure.kcl.ac.uk.
  3. "Tara Keck - Research Portal, King's College, London". kclpure.kcl.ac.uk. Retrieved 2020-05-27.
  4. UCL (2019-02-08). "keck-tara". UCL Division of Biosciences. Retrieved 2020-05-27.
  5. "Tara Keck and Tatiana Tomasi receive Outstanding Paper Award". www.neuro.mpg.de. Retrieved 2020-05-27.
  6. Netoff, Theoden I.; Clewley, Robert; Arno, Scott; Keck, Tara; White, John A. (15 September 2004). "Epilepsy in small-world networks". The Journal of Neuroscience. 24 (37): 8075–8083. doi:10.1523/JNEUROSCI.1509-04.2004. PMC 6729784. PMID 15371508.
  7. Keck, Tara; Lillis, Kyle P.; Zhou, Yu-Dong; White, John A. (16 July 2008). "Frequency-dependent glycinergic inhibition modulates plasticity in hippocampus". The Journal of Neuroscience. 28 (29): 7359–7369. doi:10.1523/JNEUROSCI.5618-07.2008. PMC 2577594. PMID 18632940.
  8. Chakravarthy, Sridhara; Keck, Tara; Roelandse, Martijn; Hartman, Robin; Jeromin, Andreas; Perry, Sean; Hofer, Sonja B.; Mrsic-Flogel, Thomas; Levelt, Christiaan N. (26 August 2008). "Cre-Dependent Expression of Multiple Transgenes in Isolated Neurons of the Adult Forebrain". PLOS ONE. 3 (8): e3059. Bibcode:2008PLoSO...3.3059C. doi:10.1371/journal.pone.0003059. PMC 2518110. PMID 18725976.
  9. Keck, Tara; Mrsic-Flogel, Thomas D.; Vaz Afonso, Miguel; Eysel, Ulf T.; Bonhoeffer, Tobias; Hübener, Mark (1 October 2008). "Massive restructuring of neuronal circuits during functional reorganization of adult visual cortex". Nature Neuroscience. 11 (10): 1162–1167. doi:10.1038/nn.2181. PMID 18758460 – via PubMed.
  10. Keck, Tara; White, John A. (8 May 2019). "Glycinergic inhibition in the hippocampus". Reviews in the Neurosciences. 20 (1): 13–22. doi:10.1515/revneuro.2009.20.1.13. PMID 19526731.
  11. Holtmaat, Anthony; Bonhoeffer, Tobias; Chow, David K.; Chuckowree, Jyoti; De Paola, Vincenzo; Hofer, Sonja B.; Hübener, Mark; Keck, Tara; Knott, Graham; Lee, Wei-Chung A.; Mostany, Ricardo; Mrsic-Flogel, Tom D.; Nedivi, Elly; Portera-Cailliau, Carlos; Svoboda, Karel; Trachtenberg, Joshua T.; Wilbrecht, Linda (8 May 2019). "Long-term, high-resolution imaging in the mouse neocortex through a chronic cranial window". Nature Protocols. 4 (8): 1128–1144. doi:10.1038/nprot.2009.89. PMC 3072839. PMID 19617885.
  12. Wierenga, Corette J.; Müllner, Fiona E.; Rinke, Ilka; Keck, Tara; Stein, Valentin; Bonhoeffer, Tobias (31 December 2010). "Molecular and electrophysiological characterization of GFP-expressing CA1 interneurons in GAD65-GFP mice". PLOS One. 5 (12): e15915. Bibcode:2010PLoSO...515915W. doi:10.1371/journal.pone.0015915. PMC 3013138. PMID 21209836.
  13. Keck, Tara; Scheuss, Volker; Jacobsen, R. Irene; Wierenga, Corette J.; Eysel, Ulf T.; Bonhoeffer, Tobias; Hübener, Mark (8 September 2011). "Loss of sensory input causes rapid structural changes of inhibitory neurons in adult mouse visual cortex". Neuron. 71 (5): 869–882. doi:10.1016/j.neuron.2011.06.034. PMID 21903080 – via PubMed.
  14. Ertürk, Ali; Mauch, Christoph P.; Hellal, Farida; Förstner, Friedrich; Keck, Tara; Becker, Klaus; Jährling, Nina; Steffens, Heinz; Richter, Melanie; Hübener, Mark; Kramer, Edgar; Kirchhoff, Frank; Dodt, Hans Ulrich; Bradke, Frank (25 December 2011). "Three-dimensional imaging of the unsectioned adult spinal cord to assess axon regeneration and glial responses after injury". Nature Medicine. 18 (1): 166–171. doi:10.1038/nm.2600. PMID 22198277 – via PubMed.
  15. Keck, Tara; Keller, Georg B.; Jacobsen, R. Irene; Eysel, Ulf T.; Bonhoeffer, Tobias; Hübener, Mark (16 October 2013). "Synaptic scaling and homeostatic plasticity in the mouse visual cortex in vivo". Neuron. 80 (2): 327–334. doi:10.1016/j.neuron.2013.08.018. PMID 24139037.
  16. Chen, Jerry L.; Andermann, Mark L.; Keck, Tara; Xu, Ning-Long; Ziv, Yaniv (6 November 2013). "Imaging neuronal populations in behaving rodents: paradigms for studying neural circuits underlying behavior in the mammalian cortex". The Journal of Neuroscience. 33 (45): 17631–17640. doi:10.1523/JNEUROSCI.3255-13.2013. PMC 3818544. PMID 24198355 – via PubMed.
  17. Lyamzin, Dmitry R.; Barnes, Samuel J.; Donato, Roberta; Garcia-Lazaro, Jose A.; Keck, Tara; Lesica, Nicholas A. (27 May 2015). "Nonlinear transfer of signal and noise correlations in cortical networks". The Journal of Neuroscience. 35 (21): 8065–8080. doi:10.1523/JNEUROSCI.4738-14.2015. PMC 4444533. PMID 26019325.
  18. Barnes, Samuel J.; Sammons, Rosanna P.; Jacobsen, R. Irene; Mackie, Jennifer; Keller, Georg B.; Keck, Tara (3 June 2015). "Subnetwork-Specific Homeostatic Plasticity in Mouse Visual Cortex In Vivo". Neuron. 86 (5): 1290–1303. doi:10.1016/j.neuron.2015.05.010. PMC 4460189. PMID 26050045 – via PubMed.
  19. Sammons, Rosanna P.; Keck, Tara (1 December 2015). "Adult plasticity and cortical reorganization after peripheral lesions". Current Opinion in Neurobiology. 35: 136–141. doi:10.1016/j.conb.2015.08.004. PMID 26313527.
  20. Keck, Tara; Toyoizumi, Taro; Chen, Lu; Doiron, Brent; Feldman, Daniel E.; Fox, Kevin; Gerstner, Wulfram; Haydon, Philip G.; Hübener, Mark; Lee, Hey-Kyoung; Lisman, John E.; Rose, Tobias; Sengpiel, Frank; Stellwagen, David; Stryker, Michael P.; Turrigiano, Gina G.; van Rossum, Mark C. (2017). "Integrating Hebbian and homeostatic plasticity: the current state of the field and future research directions". Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences. 372 (1715): 20160158. doi:10.1098/rstb.2016.0158. PMC 5247590. PMID 28093552 – via PubMed.
  21. Keck, Tara; Hübener, Mark; Bonhoeffer, Tobias (2017). "Interactions between synaptic homeostatic mechanisms: an attempt to reconcile BCM theory, synaptic scaling, and changing excitation/inhibition balance". Current Opinion in Neurobiology. 43: 87–93. doi:10.1016/j.conb.2017.02.003. PMID 28236778 – via PubMed.
  22. Barnes, Samuel J.; Franzoni, Eleonora; Jacobsen, R. Irene; Erdelyi, Ferenc; Szabo, Gabor; Clopath, Claudia; Keller, Georg B.; Keck, Tara (15 November 2017). "Deprivation-Induced Homeostatic Spine Scaling In Vivo Is Localized to Dendritic Branches that Have Undergone Recent Spine Loss". Neuron. 96 (4): 871–882.e5. doi:10.1016/j.neuron.2017.09.052. PMC 5697914. PMID 29107520.
This article is issued from Wikipedia. The text is licensed under Creative Commons - Attribution - Sharealike. Additional terms may apply for the media files.