TXNDC5

TXNDC5
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2DIZ, 3UJ1, 3UVT, 3WGD, 3WGE, 3WGX
Identifiers
Aliases	TXNDC5, ENDOPDI, ERP46, HCC-2, PDIA15, STRF8, UNQ364, HCC2, thioredoxin domain containing 5
External IDs	OMIM: 616412 MGI: 2145316 HomoloGene: 11125 GeneCards: TXNDC5
Gene location (Human)
Chr.	Chromosome 6 (human)[1]
End	7,910,788 bp[1]
Gene location (Mouse)
Chr.	Chromosome 13 (mouse)[2]
End	38,528,824 bp[2]
Gene ontology
Molecular function	• GO:0001948 protein binding; • isomerase activity; • protein disulfide isomerase activity;
Cellular component	• lysosomal lumen; • endoplasmic reticulum lumen; • extracellular exosome; • endoplasmic reticulum; • extracellular region; • azurophil granule lumen;
Biological process	• apoptotic cell clearance; • negative regulation of apoptotic process; • protein folding; • cell redox homeostasis; • response to endoplasmic reticulum stress; • neutrophil degranulation;
	Sources:Amigo / QuickGO
Orthologs
	81567
	105245
	ENSG00000239264
	ENSMUSG00000038991
	Q8NBS9
	Q91W90
	NM_030810; NM_001145549; NM_022085
	NM_001289598; NM_001289599; NM_145367
	NP_001139021; NP_110437
	NP_001276527; NP_001276528; NP_663342
	Wikidata
View/Edit Human	View/Edit Mouse

Thioredoxin domain-containing protein 5 is a protein that in humans is encoded by the TXNDC5 gene.[5]

Function

This gene encodes a protein disulfide-isomerase.[6] Its expression is induced by hypoxia and its role may be to protect hypoxic cells from apoptosis. This gene can be co-transcribed with the upstream gene MUTED.[5]

gollark: Oh, I see, they have named subcategories.

gollark: Those are pyralspites.

gollark: The eeemerald green ones?

gollark: Which ones are almadines again?

gollark: It seems that either purple siyats are one of those things which don't get asked for much but can be put up and are valuable, or the market for them is doubleplusungood now.

References

GRCh38: Ensembl release 89: ENSG00000239264 - Ensembl, May 2017
GRCm38: Ensembl release 89: ENSMUSG00000038991 - Ensembl, May 2017
"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
"Entrez Gene: TXNDC5 thioredoxin domain containing 5".
Galligan JJ, Petersen DR (July 2012). "The human protein disulfide isomerase gene family". Human Genomics. 6 (6): 6. doi:10.1186/1479-7364-6-6. PMC 3500226. PMID 23245351.

Neve EP, Svensson K, Fuxe J, Pettersson RF (Aug 2003). "VIPL, a VIP36-like membrane protein with a putative function in the export of glycoproteins from the endoplasmic reticulum". Experimental Cell Research. 288 (1): 70–83. doi:10.1016/S0014-4827(03)00161-7. PMID 12878160.
Knoblach B, Keller BO, Groenendyk J, Aldred S, Zheng J, Lemire BD, Li L, Michalak M (Oct 2003). "ERp19 and ERp46, new members of the thioredoxin family of endoplasmic reticulum proteins". Molecular & Cellular Proteomics. 2 (10): 1104–19. doi:10.1074/mcp.M300053-MCP200. PMID 12930873.
Sullivan DC, Huminiecki L, Moore JW, Boyle JJ, Poulsom R, Creamer D, Barker J, Bicknell R (Nov 2003). "EndoPDI, a novel protein-disulfide isomerase-like protein that is preferentially expressed in endothelial cells acts as a stress survival factor". The Journal of Biological Chemistry. 278 (47): 47079–88. doi:10.1074/jbc.M308124200. PMID 12963716.
Bruneel A, Labas V, Mailloux A, Sharma S, Royer N, Vinh J, Pernet P, Vaubourdolle M, Baudin B (Oct 2005). "Proteomics of human umbilical vein endothelial cells applied to etoposide-induced apoptosis". Proteomics. 5 (15): 3876–84. doi:10.1002/pmic.200401239. PMID 16130169.
Nissom PM, Lo SL, Lo JC, Ong PF, Lim JW, Ou K, Liang RC, Seow TK, Chung MC (Apr 2006). "Hcc-2, a novel mammalian ER thioredoxin that is differentially expressed in hepatocellular carcinoma". FEBS Letters. 580 (9): 2216–26. doi:10.1016/j.febslet.2006.03.029. PMID 16574106.
Wang Y, Ma Y, Lü B, Xu E, Huang Q, Lai M (Oct 2007). "Differential expression of mimecan and thioredoxin domain-containing protein 5 in colorectal adenoma and cancer: a proteomic study". Experimental Biology and Medicine. 232 (9): 1152–9. doi:10.3181/0701-RM-8. PMID 17895523.

This article is issued from Wikipedia. The text is licensed under Creative Commons - Attribution - Sharealike. Additional terms may apply for the media files.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000239264 - Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000038991 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] "Entrez Gene: TXNDC5 thioredoxin domain containing 5".

[humgenomics.com-6] Galligan JJ, Petersen DR (July 2012). "The human protein disulfide isomerase gene family". Human Genomics. 6 (6): 6. doi:10.1186/1479-7364-6-6. PMC 3500226. PMID 23245351.

TXNDC5

Function

References

Further reading