TEF (gene)

Thyrotroph embryonic factor is a protein that in humans is encoded by the TEF gene.[5][6][7]

TEF
Identifiers
AliasesTEF, PAR bZIP transcription factor, TEF transcription factor, PAR bZIP family member
External IDsOMIM: 188595 MGI: 98663 HomoloGene: 31140 GeneCards: TEF
Gene location (Human)
Chr.Chromosome 22 (human)[1]
Band22q13.2Start41,367,333 bp[1]
End41,399,326 bp[1]
RNA expression pattern
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez

7008

21685

Ensembl

ENSG00000167074

ENSMUSG00000022389

UniProt

Q10587

Q9JLC6

RefSeq (mRNA)

NM_003216
NM_001145398

NM_017376
NM_153484

RefSeq (protein)

NP_001138870
NP_003207

NP_059072
NP_705617

Location (UCSC)Chr 22: 41.37 – 41.4 MbChr 15: 81.8 – 81.83 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Thyrotroph embryonic factor (TEF), a transcription factor, is a member of the PAR (proline and acidic amino acid-rich) subfamily of basic region/leucine zipper (bZIP) transcription factors. It is expressed in a broad range of cells and tissues in adult animals, however, during embryonic development, TEF expression appears to be restricted to the developing anterior pituitary gland, coincident with the appearance of thyroid-stimulating hormone, beta (TSHB). Indeed, TEF can bind to, and transactivate the TSHB promoter.

It shows homology (in the functional domains) with other members of the PAR-bZIP subfamily of transcription factors, which include albumin D box-binding protein (DBP), human hepatic leukemia factor (HLF) and chicken vitellogenin gene-binding protein (VBP); VBP is considered the chicken homologue of TEF. Different members of the subfamily can readily form heterodimers, and share DNA-binding, and transcriptional regulatory properties.[7]

References

  1. GRCh38: Ensembl release 89: ENSG00000167074 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000022389 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Khatib ZA, Inaba T, Valentine M, Look AT (Feb 1995). "Chromosomal localization and cDNA cloning of the human DBP and TEF genes". Genomics. 23 (2): 344–51. doi:10.1006/geno.1994.1510. PMID 7835883.
  6. Inukai T, Inaba T, Dang J, Kuribara R, Ozawa K, Miyajima A, Wu W, Look AT, Arinobu Y, Iwasaki H, Akashi K, Kagami K, Goi K, Sugita K, Nakazawa S (May 2005). "TEF, an antiapoptotic bZIP transcription factor related to the oncogenic E2A-HLF chimera, inhibits cell growth by down-regulating expression of the common beta chain of cytokine receptors". Blood. 105 (11): 4437–44. doi:10.1182/blood-2004-08-2976. PMID 15665112.
  7. "Entrez Gene: TEF thyrotrophic embryonic factor".

Further reading


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