TAF1C

TATA box-binding protein-associated factor RNA polymerase I subunit C is an enzyme that in humans is encoded by the TAF1C gene.[5][6]

TAF1C
Identifiers
Aliases	TAF1C, MGC:39976, SL1, TAFI110, TAFI95, TATA-box binding protein associated factor, RNA polymerase I subunit C
External IDs	OMIM: 604905 MGI: 109576 HomoloGene: 21163 GeneCards: TAF1C
Gene location (Human) Chr. Chromosome 16 (human)[1] Band 16q24.1 Start 84,177,847 bp[1] End 84,187,070 bp[1]
Gene location (Mouse) Chr. Chromosome 8 (mouse)[2] Band 8|8 E1 Start 119,597,871 bp[2] End 119,605,222 bp[2]
RNA expression pattern More reference expression data
Gene ontology Molecular function • DNA binding • GO:0001948 protein binding • GO:0001187 RNA polymerase I core promoter sequence-specific DNA binding Cellular component • RNA polymerase I transcription factor complex • fibrillar center • nucleoplasm • nucleolus • cell nucleus Biological process • termination of RNA polymerase I transcription • transcription initiation from RNA polymerase I promoter • positive regulation of gene expression, epigenetic • transcription, DNA-templated • regulation of transcription, DNA-templated • transcription from RNA polymerase II promoter • regulation of transcription from RNA polymerase I promoter • RNA polymerase I transcriptional preinitiation complex assembly • transcription from RNA polymerase I promoter • transcription elongation from RNA polymerase I promoter Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	9013	21341
Ensembl	ENSG00000103168	ENSMUSG00000031832
UniProt	Q15572	Q6PDZ2
RefSeq (mRNA)	NM_001243156 NM_001243157 NM_001243158 NM_001243159 NM_001243160 NM_005679 NM_139353	NM_021441 NM_001378901
RefSeq (protein)	NP_001230085 NP_001230086 NP_001230087 NP_001230088 NP_001230089 NP_005670 NP_647610	NP_067416 NP_001365830
Location (UCSC)	Chr 16: 84.18 – 84.19 Mb	Chr 8: 119.6 – 119.61 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

Function

Initiation of transcription by RNA polymerase I requires the formation of a complex composed of the TATA-binding protein (TBP) and three TBP-associated factors (TAFs) specific for RNA polymerase I. This complex, known as SL1, binds to the core promoter of ribosomal RNA genes to position the polymerase properly and acts as a channel for regulatory signals. This gene encodes the largest SL1-specific TAF. Two transcripts encoding different isoforms have been identified.[6]

Interactions

TAF1C has been shown to interact with UBTF.[7][8]

References

1. GRCh38: Ensembl release 89: ENSG00000103168 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000031832 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Comai L, Zomerdijk JC, Beckmann H, Zhou S, Admon A, Tjian R (1994). "Reconstitution of transcription factor SL1: exclusive binding of TBP by SL1 or TFIID subunits". Science. 266 (5193): 1966–72. doi:10.1126/science.7801123. PMID 7801123.
6. "Entrez Gene: TAF1C TATA box binding protein (TBP)-associated factor, RNA polymerase I, C, 110kDa".
7. Voit R, Grummt I (November 2001). "Phosphorylation of UBF at serine 388 is required for interaction with RNA polymerase I and activation of rDNA transcription". Proc. Natl. Acad. Sci. U.S.A. 98 (24): 13631–6. doi:10.1073/pnas.231071698. PMC 61092. PMID 11698641.
8. Zhai W, Comai L (August 2000). "Repression of RNA polymerase I transcription by the tumor suppressor p53". Mol. Cell. Biol. 20 (16): 5930–8. doi:10.1128/MCB.20.16.5930-5938.2000. PMC 86070. PMID 10913176.

Further reading

• Di Pietro C, Rapisarda A, Amico V, Bonaiuto C, Viola A, Scalia M, Motta S, Amato A, Engel H, Messina A, Sichel G, Grzeschik K, Purrello M (2000). "Genomic localization of the human genes TAF1A, TAF1B and TAF1C, encoding TAF(I)48, TAF(I)63 and TAF(I)110 subunits of class I general transcription initiation factor SL1". Cytogenet. Cell Genet. 89 (1–2): 133–6. doi:10.1159/000015592. PMID 10894955.
• Miller G, Panov KI, Friedrich JK, Trinkle-Mulcahy L, Lamond AI, Zomerdijk JC (2001). "hRRN3 is essential in the SL1-mediated recruitment of RNA Polymerase I to rRNA gene promoters". EMBO J. 20 (6): 1373–82. doi:10.1093/emboj/20.6.1373. PMC 145519. PMID 11250903.
• Yuan X, Zhao J, Zentgraf H, Hoffmann-Rohrer U, Grummt I (2002). "Multiple interactions between RNA polymerase I, TIF-IA and TAF(I) subunits regulate preinitiation complex assembly at the ribosomal gene promoter". EMBO Rep. 3 (11): 1082–7. doi:10.1093/embo-reports/kvf212. PMC 1307603. PMID 12393749.
• Yamamoto K, Yamamoto M, Hanada K, Nogi Y, Matsuyama T, Muramatsu M (2004). "Multiple protein-protein interactions by RNA polymerase I-associated factor PAF49 and role of PAF49 in rRNA transcription". Mol. Cell. Biol. 24 (14): 6338–49. doi:10.1128/MCB.24.14.6338-6349.2004. PMC 434256. PMID 15226435.
• Grandori C, Gomez-Roman N, Felton-Edkins ZA, Ngouenet C, Galloway DA, Eisenman RN, White RJ (2005). "c-Myc binds to human ribosomal DNA and stimulates transcription of rRNA genes by RNA polymerase I". Nat. Cell Biol. 7 (3): 311–8. doi:10.1038/ncb1224. PMID 15723054.
• Friedrich JK, Panov KI, Cabart P, Russell J, Zomerdijk JC (2005). "TBP-TAF complex SL1 directs RNA polymerase I pre-initiation complex formation and stabilizes upstream binding factor at the rDNA promoter". J. Biol. Chem. 280 (33): 29551–8. doi:10.1074/jbc.M501595200. PMC 3858828. PMID 15970593.
• Zhang C, Comai L, Johnson DL (2005). "PTEN represses RNA Polymerase I transcription by disrupting the SL1 complex". Mol. Cell. Biol. 25 (16): 6899–911. doi:10.1128/MCB.25.16.6899-6911.2005. PMC 1190253. PMID 16055704.
• Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.
• Kimura K, Wakamatsu A, Suzuki Y, Ota T, Nishikawa T, Yamashita R, Yamamoto J, Sekine M, Tsuritani K, Wakaguri H, Ishii S, Sugiyama T, Saito K, Isono Y, Irie R, Kushida N, Yoneyama T, Otsuka R, Kanda K, Yokoi T, Kondo H, Wagatsuma M, Murakawa K, Ishida S, Ishibashi T, Takahashi-Fujii A, Tanase T, Nagai K, Kikuchi H, Nakai K, Isogai T, Sugano S (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC 1356129. PMID 16344560.