Secretagogin

Secretagogin is a protein that in humans is encoded by the SCGN gene.[5][6]

SCGN
Identifiers
Aliases	SCGN, CALBL, DJ501N12.8, SECRET, SEGN, setagin, secretagogin, EF-hand calcium binding protein
External IDs	OMIM: 609202 MGI: 2384873 HomoloGene: 5088 GeneCards: SCGN
Gene location (Human) Chr. Chromosome 6 (human)[1] Band 6p22.2 Start 25,652,201 bp[1] End 25,701,783 bp[1]
Gene location (Mouse) Chr. Chromosome 13 (mouse)[2] Band 13|13 A3.1 Start 23,953,456 bp[2] End 23,991,214 bp[2]
RNA expression pattern More reference expression data
Gene ontology Molecular function • calcium ion binding • metal ion binding Cellular component • cytoplasm • extracellular region • neuron projection • cytosol • transport vesicle membrane • synapse • membrane • cytoplasmic vesicle • cell nucleus • dendrite • presynapse Biological process • regulation of cytosolic calcium ion concentration • biological process • regulation of presynaptic cytosolic calcium ion concentration • regulation of long-term synaptic potentiation Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	10590	214189
Ensembl	ENSG00000079689	ENSMUSG00000021337
UniProt	O76038	Q91WD9
RefSeq (mRNA)	NM_006998	NM_145399
RefSeq (protein)	NP_008929	NP_663374
Location (UCSC)	Chr 6: 25.65 – 25.7 Mb	Chr 13: 23.95 – 23.99 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

Function

The encoded protein is a secreted calcium-binding protein which is found in the cytoplasm. It is related to calbindin D-28K and calretinin. This protein is thought to be involved in potassium chloride-stimulated calcium flux and cell proliferation.[6] This protein plays an important role in the release of the stress hormone Corticotropin-releasing hormone (CRH) and which only then enables stress processes in the brain.

References

1. GRCh38: Ensembl release 89: ENSG00000079689 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000021337 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Wagner L; Oliyarnyk O; Gartner W; Nowotny P; Groeger M; Kaserer K; Waldhausl W; Pasternack MS (Sep 2000). "Cloning and expression of secretagogin, a novel neuroendocrine- and pancreatic islet of Langerhans-specific Ca2+-binding protein". J Biol Chem. 275 (32): 24740–51. doi:10.1074/jbc.M001974200. PMID 10811645.
6. "Entrez Gene: SCGN secretagogin, EF-hand calcium binding protein".

Further reading

• Gartner W, Lang W, Leutmetzer F, et al. (2002). "Cerebral expression and serum detectability of secretagogin, a recently cloned EF-hand Ca(2+)-binding protein". Cereb. Cortex. 11 (12): 1161–9. doi:10.1093/cercor/11.12.1161. PMID 11709487.
• Mungall AJ, Palmer SA, Sims SK, et al. (2003). "The DNA sequence and analysis of human chromosome 6". Nature. 425 (6960): 805–11. doi:10.1038/nature02055. PMID 14574404.
• Zhan X; Evans CO; Oyesiku NM; Desiderio DM (2004). "Proteomics and transcriptomics analyses of secretagogin down-regulation in human non-functional pituitary adenomas". Pituitary. 6 (4): 189–202. doi:10.1023/B:PITU.0000023426.99808.40. PMID 15237930.
• Zierhut B, Daneva T, Gartner W, et al. (2005). "Setagin and secretagogin-R22: Posttranscriptional modification products of the secretagogin gene". Biochem. Biophys. Res. Commun. 329 (4): 1193–9. doi:10.1016/j.bbrc.2005.02.093. PMID 15766553.
• Skovhus KV, Bergholdt R, Erichsen C, et al. (2007). "Identification and characterization of secretagogin promoter activity". Scand. J. Immunol. 64 (6): 639–45. doi:10.1111/j.1365-3083.2006.01854.x. PMID 17083620.
• Romanov R.; Alpar A.; et al. (2014). "A secretagogin locus of the mammalian hypothalamus controls stress hormone release". EMBO Journal. 34 (1): 36–54. doi:10.15252/embj.201488977. PMC 4291479. PMID 25430741.