Scavenger receptor cysteine-rich protein domain

In molecular biology, the protein domain SRCR is short for Scavenger receptor cysteine-rich domain. They are found solely in eukaryotes. These domains are present on the cell membrane and have a role in binding to specific ligands and are often found to be involved with the immune system.[1]

SRCR
structure of m2bp scavenger receptor cysteine-rich domain
Identifiers
SymbolSRCR
PfamPF00530
InterProIPR001190
PROSITEPDOC00348
SCOPe1by2 / SUPFAM

Function

The function of these endocytic receptors are to mediating non-opsonic phagocytosis in response to foreign ligands. This triggers various processes of host defence and immune response.[2]

Structure

The structure contains a six stranded beta-sheet and one alpha-helix.[1]

Examples

The speract receptor found in egg, is a transmembrane glycoprotein.[3] Other members of this family include the macrophage scavenger receptor type I, an enteropeptidase, and T-cell surface glycoprotein CD5.

gollark: Issue is, you can only have one actual live copy of a page at a time.
gollark: I see.
gollark: <@332271551481118732> So why do you think tree/graph revisions are valuable?
gollark: Based on testing my internal time guessing loses a few seconds per minute.
gollark: It's useful to have it there to check quickly even if you don't constantly need it and the cost isn't significant.

References
  1. Hohenester E; Sasaki T; Timpl R (1999). "Crystal structure of a scavenger receptor cysteine-rich domain sheds light on an ancient superfamily". Nat Struct Biol. 6 (3): 228–32. doi:10.1038/6669. PMID 10074941.
  2. Liu L, Yang J, Qiu L, Wang L, Zhang H, Wang M, et al. (2011). "A novel scavenger receptor-cysteine-rich (SRCR) domain containing scavenger receptor identified from mollusk mediated PAMP recognition and binding". Dev Comp Immunol. 35 (2): 227–39. doi:10.1016/j.dci.2010.09.010. PMID 20888856.
  3. Resnick D; Pearson A; Krieger M (January 1994). "The SRCR superfamily: a family reminiscent of the Ig superfamily". Trends Biochem. Sci. 19 (1): 5–8. doi:10.1016/0968-0004(94)90165-1. PMID 8140623.
This article incorporates text from the public domain Pfam and InterPro: IPR001190
This article is issued from Wikipedia. The text is licensed under Creative Commons - Attribution - Sharealike. Additional terms may apply for the media files.