Santa Cruz Biotechnology

Santa Cruz Biotechnology is a developer of biological products for medical research,[1][2] and is one of the world’s largest suppliers of antibodies.[3] The company was founded in 1991 by Dr. John Stephenson and his wife Brenda Stephenson in Santa Cruz, California.[4] Santa Cruz Biotechnology headquarters are located in Dallas, Texas, with additional US facilities in Paso Robles, California,[5] and Sun Valley, Idaho. The company also has international locations in Germany, Shanghai and Canada.[6]

History

The company was originally headquartered in Santa Cruz, California, and began offering antibodies to the research community.[7] Other products lines were added over the years – siRNAs in 2007,[8] shRNAs in 2009,[9] and laboratory supplies in 2010.

In 2010, the offering of biochemical was expanded from just a few hundred to over 100,000 different products.[10] Products related to CRISPR were introduced in 2015[11] for over 37,000 mouse and human genes.

Santa Cruz Biotechnology has had issues with the USDA for a number of years due to allegations of Animal Welfare Act violations. In May 2016, the company settled with the USDA, paying a $3.5 million fine for its alleged violations and agreed to the revocation of its polyclonal antibody dealer license effective from December 31, 2016.[12][13]

gollark: Is their problem the passive bit, or the aggressive bit?
gollark: Maybe you can configure your phone keyboard to replace "Lol" with "I hate you" or something.
gollark: (I mean, internally they probably work differently, but it's not like having radio options with satellite TV is an amazing technical achievement)
gollark: Radio is just TV with the video signal missing.
gollark: I wonder how hard/expensive it'd be to run your own channel on the satellite system if there are THAT many.

References
  1. "Santa Cruz Biotechnology opens office in Idaho".
  2. "Santa Cruz Biotechnology, Inc.: Private Company Information - Bloomberg".
  3. "Economic growth pushes SLO County higher in national ranking".
  4. "Idaho Mountain Express: Biotechnology firm sets up shop in Ketchum - December 3, 2008".
  5. "Paso Robles Press Santa Cruz Biotech breaks ground on new building".
  6. "Santa Cruz Biotechnology Opens New Office in Canada".
  7. Jeang, K. T.; Chun, R; Lin, N. H.; Gatignol, A; Glabe, C. G.; Fan, H (1993). "In vitro and in vivo binding of human immunodeficiency virus type 1 Tat protein and Sp1 transcription factor". Journal of Virology. 67 (10): 6224–6233. doi:10.1128/JVI.67.10.6224-6233.1993. PMC 238044. PMID 7690421.
  8. Takemura, Yukihiro; Ouchi, Noriyuki; Shibata, Rei; Aprahamian, Tamar; Kirber, Michael T.; Summer, Ross S.; Kihara, Shinji; Walsh, Kenneth (1 February 2007). "Adiponectin modulates inflammatory reactions via calreticulin receptor–dependent clearance of early apoptotic bodies". J Clin Invest. 117 (2): 375–386. doi:10.1172/JCI29709. PMC 1770947. PMID 17256056.
  9. Xiao, Qingzhong; Luo, Zhenling; Pepe, Anna Elena; Margariti, Andriani; Zeng, Lingfang; Xu, Qingbo (1 April 2009). "Embryonic stem cell differentiation into smooth muscle cells is mediated by Nox4-produced H2O2". American Journal of Physiology. Cell Physiology. 296 (4): C711–C723. doi:10.1152/ajpcell.00442.2008. PMID 19036941 – via ajpcell.physiology.org.
  10. Zucal, Chiara; D’Agostino, Vito G.; Casini, Antonio; Mantelli, Barbara; Thongon, Natthakan; Soncini, Debora; Caffa, Irene; Cea, Michele; Ballestrero, Alberto; Quattrone, Alessandro; Indraccolo, Stefano; Nencioni, Alessio; Provenzani, Alessandro (5 November 2015). "EIF2A-dependent translational arrest protects leukemia cells from the energetic stress induced by NAMPT inhibition". BMC Cancer. 15: 855. doi:10.1186/s12885-015-1845-1. PMC 4636066. PMID 26542945.
  11. Faddaoui, Adnen; Bachvarova, Magdalena; Plante, Marie; Gregoire, Jean; Renaud, Marie-Claude; Sebastianelli, Alexandra; Gobeil, Stephane; Morin, Chantale; Macdonald, Elizabeth; Vanderhyden, Barbara; Bachvarov, Dimcho (9 February 2016). "The mannose receptor LY75 (DEC205/CD205) modulates cellular phenotype and metastatic potential of ovarian cancer cells". Oncotarget. 7 (12): 14125–14142. doi:10.18632/oncotarget.7288. PMC 4924702. PMID 26871602.
  12. Editor (16 June 2016). "Santa Cruz Biotechnology and the USDA".CS1 maint: extra text: authors list (link)
  13. Reardon, Sara (2016). "US government issues historic $3.5-million fine over animal welfare". Nature. doi:10.1038/nature.2016.19958.
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