SUMO2

Small ubiquitin-related modifier 2 is a protein that in humans is encoded by the SUMO2 gene.[5]

SUMO2
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesSUMO2, HSMT3, SMT3B, SMT3H2, SUMO3, Smt3A, small ubiquitin-like modifier 2, small ubiquitin like modifier 2
External IDsOMIM: 603042 MGI: 2158813 HomoloGene: 87858 GeneCards: SUMO2
Gene location (Human)
Chr.Chromosome 17 (human)[1]
Band17q25.1Start75,165,586 bp[1]
End75,182,959 bp[1]
Orthologs
SpeciesHumanMouse
Entrez

6613

170930

Ensembl

ENSG00000188612

ENSMUSG00000020738

UniProt

P61956

P61957

RefSeq (mRNA)

NM_001005849
NM_006937

NM_133354

RefSeq (protein)

NP_001005849
NP_008868

NP_579932

Location (UCSC)Chr 17: 75.17 – 75.18 MbChr 11: 115.52 – 115.54 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Function

This gene encodes a protein that is a member of the SUMO (small ubiquitin-like modifier) protein family. It functions in a manner similar to ubiquitin in that it is bound to target proteins as part of a post-translational modification system. However, unlike ubiquitin which targets proteins for degradation, this protein is involved in a variety of cellular processes, such as nuclear transport, transcriptional regulation, apoptosis, and protein stability. It is not active until the last two amino acids of the carboxy-terminus have been cleaved off. Numerous pseudogenes have been reported for this gene. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.[6]

Interactions

SUMO2 has been shown to interact with TRIM63[7] and c21orf59.[8]

gollark: I see.
gollark: If *a lot* of people want change, *and* can somehow coordinate on this, in the face of people trying to stop them, and it doesn't go horribly wrong somehow.
gollark: That's not exactly better if it leads to worse outcomes.
gollark: I mean, if you go around trying revolutioning, this will:- probably turn out badly for you- also probably not do much
gollark: I don't agree. "People" in aggregate can, but you aren't that.

References
  1. GRCh38: Ensembl release 89: ENSG00000188612 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000020738 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Mannen H, Tseng HM, Cho CL, Li SS (May 1996). "Cloning and expression of human homolog HSMT3 to yeast SMT3 suppressor of MIF2 mutations in a centromere protein gene". Biochemical and Biophysical Research Communications. 222 (1): 178–80. doi:10.1006/bbrc.1996.0717. PMID 8630065.
  6. "Entrez Gene: SUMO2 SMT3 suppressor of mif two 3 homolog 2 (S. cerevisiae)".
  7. Dai KS, Liew CC (Jun 2001). "A novel human striated muscle RING zinc finger protein, SMRZ, interacts with SMT3b via its RING domain". The Journal of Biological Chemistry. 276 (26): 23992–9. doi:10.1074/jbc.M011208200. PMID 11283016.
  8. Golebiowski F, Matic I, Tatham MH, Cole C, Yin Y, Nakamura A, Cox J, Barton GJ, Mann M, Hay RT (2009). "System-wide changes to SUMO modifications in response to heat shock". Science Signaling. 2 (72): ra24. doi:10.1126/scisignal.2000282. PMID 19471022.

Further reading
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