STRN3

Striatin-3 is a protein that in humans is encoded by the STRN3 gene.[5][6][7]

STRN3
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 4N6J
Identifiers
Aliases	STRN3, SG2NA, PPP2R6B, striatin 3, S/G2NA
External IDs	OMIM: 614766 MGI: 2151064 HomoloGene: 82078 GeneCards: STRN3
Gene location (Human) Chr. Chromosome 14 (human)[1] Band 14q12 Start 30,893,799 bp[1] End 31,026,401 bp[1]
Gene location (Mouse) Chr. Chromosome 12 (mouse)[2] Band 12|12 B3 Start 51,609,632 bp[2] End 51,691,897 bp[2]
RNA expression pattern More reference expression data
Gene ontology Molecular function • GO:0001131, GO:0001151, GO:0001130, GO:0001204 DNA-binding transcription factor activity • protein phosphatase 2A binding • GO:0001948 protein binding • calmodulin binding • armadillo repeat domain binding • Rho GTPase binding • GO:0032403 macromolecular complex binding Cellular component • cytoplasm • neuronal cell body • cell membrane • Golgi apparatus • dendrite • protein phosphatase type 2A complex • membrane • cell nucleus • nucleoplasm • macromolecular complex • FAR/SIN/STRIPAK complex Biological process • response to estradiol • negative regulation of intracellular estrogen receptor signaling pathway • negative regulation of transcription from RNA polymerase II promoter • negative regulation of transcription, DNA-templated • positive regulation of transcription from RNA polymerase II promoter Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	29966	94186
Ensembl	ENSG00000196792	ENSMUSG00000020954
UniProt	Q13033	Q9ERG2
RefSeq (mRNA)	NM_001083893 NM_014574	NM_001172098 NM_052973 NM_001364437
RefSeq (protein)	NP_001077362 NP_055389	NP_001165569 NP_443205 NP_001351366
Location (UCSC)	Chr 14: 30.89 – 31.03 Mb	Chr 12: 51.61 – 51.69 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

Interactions

STRN3 has been shown to interact with:

• CTTNBP2NL,[8]
• CTTNBP2,[8]
• FAM40A,[8]
• MOBKL3,[8]
• PDCD10,[8]
• PPP2CA,[8]
• PPP2R1A,[8]
• RP6-213H19.1,[8]
• STK24,[8][9] and
• STRN.[8]

References

1. GRCh38: Ensembl release 89: ENSG00000196792 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000020954 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Muro Y, Chan EK, Landberg G, Tan EM (Mar 1995). "A cell-cycle nuclear autoantigen containing WD-40 motifs expressed mainly in S and G2 phase cells". Biochem. Biophys. Res. Commun. 207 (3): 1029–37. doi:10.1006/bbrc.1995.1288. PMID 7864889.
6. Moreno CS, Park S, Nelson K, Ashby D, Hubalek F, Lane WS, Pallas DC (Mar 2000). "WD40 repeat proteins striatin and S/G(2) nuclear autoantigen are members of a novel family of calmodulin-binding proteins that associate with protein phosphatase 2A". J. Biol. Chem. 275 (8): 5257–63. doi:10.1074/jbc.275.8.5257. PMC 3505218. PMID 10681496.
7. "Entrez Gene: STRN3 striatin, calmodulin binding protein 3".
8. Goudreault M, D'Ambrosio LM, Kean MJ, Mullin MJ, Larsen BG, Sanchez A, Chaudhry S, Chen GI, Sicheri F, Nesvizhskii AI, Aebersold R, Raught B, Gingras AC (Jan 2009). "A PP2A phosphatase high density interaction network identifies a novel striatin-interacting phosphatase and kinase complex linked to the cerebral cavernous malformation 3 (CCM3) protein". Mol. Cell. Proteomics. 8 (1): 157–71. doi:10.1074/mcp.M800266-MCP200. PMC 2621004. PMID 18782753.
9. Ewing RM, Chu P, Elisma F, Li H, Taylor P, Climie S, McBroom-Cerajewski L, Robinson MD, O'Connor L, Li M, Taylor R, Dharsee M, Ho Y, Heilbut A, Moore L, Zhang S, Ornatsky O, Bukhman YV, Ethier M, Sheng Y, Vasilescu J, Abu-Farha M, Lambert JP, Duewel HS, Stewart II, Kuehl B, Hogue K, Colwill K, Gladwish K, Muskat B, Kinach R, Adams SL, Moran MF, Morin GB, Topaloglou T, Figeys D (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry". Mol. Syst. Biol. 3: 89. doi:10.1038/msb4100134. PMC 1847948. PMID 17353931.

Further reading

• Landberg G, Tan EM (1994). "Characterization of a DNA-binding nuclear autoantigen mainly associated with S phase and G2 cells". Exp. Cell Res. 212 (2): 255–61. doi:10.1006/excr.1994.1141. PMID 7910562.
• Castets F, Rakitina T, Gaillard S, Moqrich A, Mattei MG, Monneron A (2000). "Zinedin, SG2NA, and striatin are calmodulin-binding, WD repeat proteins principally expressed in the brain". J. Biol. Chem. 275 (26): 19970–7. doi:10.1074/jbc.M909782199. PMID 10748158.
• Moreno CS, Lane WS, Pallas DC (2001). "A mammalian homolog of yeast MOB1 is both a member and a putative substrate of striatin family-protein phosphatase 2A complexes". J. Biol. Chem. 276 (26): 24253–60. doi:10.1074/jbc.M102398200. PMC 3503316. PMID 11319234.
• Beausoleil SA, Jedrychowski M, Schwartz D, Elias JE, Villén J, Li J, Cohn MA, Cantley LC, Gygi SP (2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins". Proc. Natl. Acad. Sci. U.S.A. 101 (33): 12130–5. doi:10.1073/pnas.0404720101. PMC 514446. PMID 15302935.
• Kimura K, Wakamatsu A, Suzuki Y, Ota T, Nishikawa T, Yamashita R, Yamamoto J, Sekine M, Tsuritani K, Wakaguri H, Ishii S, Sugiyama T, Saito K, Isono Y, Irie R, Kushida N, Yoneyama T, Otsuka R, Kanda K, Yokoi T, Kondo H, Wagatsuma M, Murakawa K, Ishida S, Ishibashi T, Takahashi-Fujii A, Tanase T, Nagai K, Kikuchi H, Nakai K, Isogai T, Sugano S (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC 1356129. PMID 16344560.
• Foster LJ, Rudich A, Talior I, Patel N, Huang X, Furtado LM, Bilan PJ, Mann M, Klip A (2006). "Insulin-dependent interactions of proteins with GLUT4 revealed through stable isotope labeling by amino acids in cell culture (SILAC)". J. Proteome Res. 5 (1): 64–75. doi:10.1021/pr0502626. PMID 16396496.
• Beausoleil SA, Villén J, Gerber SA, Rush J, Gygi SP (2006). "A probability-based approach for high-throughput protein phosphorylation analysis and site localization". Nat. Biotechnol. 24 (10): 1285–92. doi:10.1038/nbt1240. PMID 16964243.
• Ewing RM, Chu P, Elisma F, Li H, Taylor P, Climie S, McBroom-Cerajewski L, Robinson MD, O'Connor L, Li M, Taylor R, Dharsee M, Ho Y, Heilbut A, Moore L, Zhang S, Ornatsky O, Bukhman YV, Ethier M, Sheng Y, Vasilescu J, Abu-Farha M, Lambert JP, Duewel HS, Stewart II, Kuehl B, Hogue K, Colwill K, Gladwish K, Muskat B, Kinach R, Adams SL, Moran MF, Morin GB, Topaloglou T, Figeys D (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry". Mol. Syst. Biol. 3 (1): 89. doi:10.1038/msb4100134. PMC 1847948. PMID 17353931.