SOSTDC1

Sclerostin domain-containing protein 1 is a protein that in humans is encoded by the SOSTDC1 gene.[5]

SOSTDC1
Identifiers
Aliases	SOSTDC1, ECTODIN, USAG1, CDA019, DAND7, sclerostin domain containing 1
External IDs	OMIM: 609675 MGI: 1913292 HomoloGene: 9154 GeneCards: SOSTDC1
Gene location (Human) Chr. Chromosome 7 (human)[1] Band 7p21.2 Start 16,461,481 bp[1] End 16,530,580 bp[1]
Gene location (Mouse) Chr. Chromosome 12 (mouse)[2] Band 12|12 A3 Start 36,314,139 bp[2] End 36,318,452 bp[2]
RNA expression pattern More reference expression data
Gene ontology Molecular function • BMP binding • BMP receptor activity Cellular component • extracellular region • extracellular Biological process • pattern specification process • odontogenesis of dentin-containing tooth • hair follicle morphogenesis • mammary gland bud morphogenesis • negative regulation of cell fate commitment • Wnt signaling pathway • negative regulation of canonical Wnt signaling pathway • negative regulation of Wnt signaling pathway • BMP signaling pathway • negative regulation of BMP signaling pathway • negative regulation of myoblast differentiation • negative regulation of determination of dorsal identity Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	25928	66042
Ensembl	ENSG00000171243	ENSMUSG00000036169
UniProt	Q6X4U4	Q9CQN4
RefSeq (mRNA)	NM_015464	NM_025312
RefSeq (protein)	NP_056279	NP_079588
Location (UCSC)	Chr 7: 16.46 – 16.53 Mb	Chr 12: 36.31 – 36.32 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

Function

This gene is a member of the sclerostin family and encodes an N-glycosylated, secreted protein with a C-terminal, cystine, knot-like domain. This protein functions as a bone morphogenetic protein (BMP) antagonist. Specifically, it directly associates with BMPs, prohibiting them from binding their receptors, thereby regulating BMP signaling during cellular proliferation, differentiation, and programmed cell death.[5]

References

1. GRCh38: Ensembl release 89: ENSG00000171243 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000036169 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. "Entrez Gene: SOSTDC1 sclerostin domain containing 1".

Further reading

• Yanagita M (June 2005). "BMP antagonists: their roles in development and involvement in pathophysiology". Cytokine & Growth Factor Reviews. 16 (3): 309–17. doi:10.1016/j.cytogfr.2005.02.007. PMID 15951218.
• Laurikkala J, Kassai Y, Pakkasjärvi L, Thesleff I, Itoh N (December 2003). "Identification of a secreted BMP antagonist, ectodin, integrating BMP, FGF, and SHH signals from the tooth enamel knot". Developmental Biology. 264 (1): 91–105. doi:10.1016/j.ydbio.2003.08.011. PMID 14623234.
• Yanagita M, Oka M, Watabe T, Iguchi H, Niida A, Takahashi S, Akiyama T, Miyazono K, Yanagisawa M, Sakurai T (April 2004). "USAG-1: a bone morphogenetic protein antagonist abundantly expressed in the kidney". Biochemical and Biophysical Research Communications. 316 (2): 490–500. doi:10.1016/j.bbrc.2004.02.075. PMID 15020244.
• Goto M, Eddy EM (October 2004). "Speriolin is a novel spermatogenic cell-specific centrosomal protein associated with the seventh WD motif of Cdc20". The Journal of Biological Chemistry. 279 (40): 42128–38. doi:10.1074/jbc.M403190200. PMID 15280373.