SMG5

Protein SMG5 is a protein that in humans is encoded by the SMG5 gene.[5][6][7] This protein contains a PIN domain that appears to have mutated the residues in the active site.[8]

SMG5
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2HWY
Identifiers
Aliases	SMG5, EST1B, LPTS-RP1, LPTSRP1, SMG-5, nonsense mediated mRNA decay factor, SMG5 nonsense mediated mRNA decay factor
External IDs	OMIM: 610962 MGI: 2447364 HomoloGene: 9095 GeneCards: SMG5
Gene location (Human) Chr. Chromosome 1 (human)[1] Band 1q22 Start 156,249,224 bp[1] End 156,282,825 bp[1]
Gene location (Mouse) Chr. Chromosome 3 (mouse)[2] Band 3|3 F1 Start 88,336,260 bp[2] End 88,362,338 bp[2]
RNA expression pattern More reference expression data
Gene ontology Molecular function • protein phosphatase 2A binding • histone deacetylase binding • GO:0001948 protein binding • telomeric DNA binding • ubiquitin protein ligase binding • ribonuclease activity • ribonucleoprotein complex binding • telomerase RNA binding Cellular component • cytoplasm • cytosol • cell nucleus • telomerase holoenzyme complex Biological process • regulation of dephosphorylation • nuclear-transcribed mRNA catabolic process, nonsense-mediated decay • mRNA export from nucleus • regulation of telomere maintenance • regulation of telomere maintenance via telomerase • regulation of RNA stability • RNA phosphodiester bond hydrolysis • telomere maintenance via telomerase Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	23381	229512
Ensembl	ENSG00000198952	ENSMUSG00000001415
UniProt	Q9UPR3	Q6ZPY2
RefSeq (mRNA)	NM_015327 NM_001323614 NM_001323615 NM_001323616 NM_001323617	NM_173188 NM_178246
RefSeq (protein)	NP_001310543 NP_001310544 NP_001310545 NP_001310546 NP_056142	NP_839977
Location (UCSC)	Chr 1: 156.25 – 156.28 Mb	Chr 3: 88.34 – 88.36 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

References

1. GRCh38: Ensembl release 89: ENSG00000198952 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000001415 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Reichenbach P, Hoss M, Azzalin CM, Nabholz M, Bucher P, Lingner J (Apr 2003). "A human homolog of yeast Est1 associates with telomerase and uncaps chromosome ends when overexpressed". Curr Biol. 13 (7): 568–74. doi:10.1016/S0960-9822(03)00173-8. PMID 12676087.
6. Snow BE, Erdmann N, Cruickshank J, Goldman H, Gill RM, Robinson MO, Harrington L (Apr 2003). "Functional conservation of the telomerase protein Est1p in humans". Curr Biol. 13 (8): 698–704. doi:10.1016/S0960-9822(03)00210-0. PMID 12699629.
7. "Entrez Gene: SMG5 Smg-5 homolog, nonsense mediated mRNA decay factor (C. elegans)".
8. Glavan F, Behm-Ansmant I, Izaurralde E, Conti E (November 2006). "Structures of the PIN domains of SMG6 and SMG5 reveal a nuclease within the mRNA surveillance complex". EMBO J. 25 (21): 5117–25. doi:10.1038/sj.emboj.7601377. PMC 1630413. PMID 17053788.

Further reading

• Nakajima D, Okazaki N, Yamakawa H, et al. (2003). "Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones". DNA Res. 9 (3): 99–106. doi:10.1093/dnares/9.3.99. PMID 12168954.
• Kikuno R, Nagase T, Ishikawa K, et al. (1999). "Prediction of the coding sequences of unidentified human genes. XIV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Res. 6 (3): 197–205. doi:10.1093/dnares/6.3.197. PMID 10470851.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Ohnishi T, Yamashita A, Kashima I, et al. (2004). "Phosphorylation of hUPF1 induces formation of mRNA surveillance complexes containing hSMG-5 and hSMG-7". Mol. Cell. 12 (5): 1187–200. doi:10.1016/S1097-2765(03)00443-X. PMID 14636577.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Unterholzner L, Izaurralde E (2005). "SMG7 acts as a molecular link between mRNA surveillance and mRNA decay". Mol. Cell. 16 (4): 587–96. doi:10.1016/j.molcel.2004.10.013. PMID 15546618.
• Fukuhara N, Ebert J, Unterholzner L, et al. (2005). "SMG7 is a 14-3-3-like adaptor in the nonsense-mediated mRNA decay pathway". Mol. Cell. 17 (4): 537–47. doi:10.1016/j.molcel.2005.01.010. PMID 15721257.
• Azzalin CM, Lingner J (2006). "The human RNA surveillance factor UPF1 is required for S phase progression and genome stability". Curr. Biol. 16 (4): 433–9. doi:10.1016/j.cub.2006.01.018. PMID 16488880.
• Gregory SG, Barlow KF, McLay KE, et al. (2006). "The DNA sequence and biological annotation of human chromosome 1". Nature. 441 (7091): 315–21. doi:10.1038/nature04727. PMID 16710414.
• Lee H, Sengupta N, Villagra A, et al. (2006). "Histone deacetylase 8 safeguards the human ever-shorter telomeres 1B (hEST1B) protein from ubiquitin-mediated degradation". Mol. Cell. Biol. 26 (14): 5259–69. doi:10.1128/MCB.01971-05. PMC 1592721. PMID 16809764.