PIN domain

Available protein structures:
Pfam	structures / ECOD
PDB	RCSB PDB; PDBe; PDBj
PDBsum	structure summary
PDB	3dbo, 1v8o, 1o4w

PIN domain
	Crystal structure of PIN (PilT N-terminus) domain (AF0591) from Archaeoglobus fulgidus at 1.90 Angstrom resolution. 1o4w
Identifiers
Symbol	PIN
Pfam	PF01850
InterPro	IPR002716
SMART	CBS
SCOPe	3dbo / SUPFAM
CDD	cd09852
Available protein structures:
Pfam	structures / ECOD
PDB	RCSB PDB; PDBe; PDBj
PDBsum	structure summary
PDB	3dbo, 1v8o, 1o4w

In molecular biology the PIN domain is a protein domain that is about 130 amino acids in length. PIN domains function as nuclease enzymes that cleave single stranded RNA in a sequence- or structure-dependent manner.[1][2]

PIN domains contain four nearly invariant acidic residues.[2] Crystal structures show these residues clustered together in the putative active site. In eukaryotes PIN domains are found in proteins involved in nonsense mediated mRNA decay, in proteins such as SMG5 and SMG6, and in processing of 18S ribosomal RNA. The majority of PIN-domain proteins found in prokaryotes are the toxic components of toxin-antitoxin operons.[2] These loci provide a control mechanism that helps free-living prokaryotes cope with nutritional stress.[3]

References

Arcus VL, McKenzie JL, Robson J, Cook GM (January 2011). "The PIN-domain ribonucleases and the prokaryotic VapBC toxin-antitoxin array". Protein Engineering, Design & Selection. 24 (1–2): 33–40. doi:10.1093/protein/gzq081. PMID 21036780.
Matelska D, Steczkiewicz K, Ginalski K (July 2017). "Comprehensive classification of the PIN domain-like superfamily". Nucleic Acids Research. 45 (12): 6995–7020. doi:10.1093/nar/gkx494. PMC 5499597. PMID 28575517.
Gerdes K, Christensen SK, Løbner-Olesen A (May 2005). "Prokaryotic toxin-antitoxin stress response loci". Nature Reviews. Microbiology. 3 (5): 371–82. doi:10.1038/nrmicro1147. PMID 15864262.

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[pmid21036780-1] Arcus VL, McKenzie JL, Robson J, Cook GM (January 2011). "The PIN-domain ribonucleases and the prokaryotic VapBC toxin-antitoxin array". Protein Engineering, Design & Selection. 24 (1–2): 33–40. doi:10.1093/protein/gzq081. PMID 21036780.

[:0-2] Matelska D, Steczkiewicz K, Ginalski K (July 2017). "Comprehensive classification of the PIN domain-like superfamily". Nucleic Acids Research. 45 (12): 6995–7020. doi:10.1093/nar/gkx494. PMC 5499597. PMID 28575517.

[pmid15864262-3] Gerdes K, Christensen SK, Løbner-Olesen A (May 2005). "Prokaryotic toxin-antitoxin stress response loci". Nature Reviews. Microbiology. 3 (5): 371–82. doi:10.1038/nrmicro1147. PMID 15864262.