SH3BP4

SH3 domain-binding protein 4 is a protein that in humans is encoded by the SH3BP4 gene.[5][6]

SH3BP4
Identifiers
Aliases	SH3BP4, BOG25, TTP, SH3 domain binding protein 4
External IDs	OMIM: 605611 MGI: 2138297 HomoloGene: 8726 GeneCards: SH3BP4
Gene location (Human) Chr. Chromosome 2 (human)[1] Band 2q37.2 Start 234,952,017 bp[1] End 235,055,714 bp[1]
Gene location (Mouse) Chr. Chromosome 1 (mouse)[2] Band 1|1 D Start 89,070,415 bp[2] End 89,155,068 bp[2]
RNA expression pattern More reference expression data
Gene ontology Molecular function • GO:0001948 protein binding • identical protein binding • GDP-dissociation inhibitor activity • Ras GTPase binding Cellular component • cytoplasm • membrane • clathrin-coated pit • cytoplasmic vesicle • extracellular exosome • cell nucleus • clathrin-coated vesicle Biological process • cellular response to amino acid stimulus • protein localization to lysosome • GO:0034259 negative regulation of GTPase activity • GO:0048552 regulation of catalytic activity • endocytosis • negative regulation of cell growth • positive regulation of autophagy • amino acid import • negative regulation of cell proliferation • negative regulation of TOR signaling Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	23677	98402
Ensembl	ENSG00000130147	ENSMUSG00000036206
UniProt	Q9P0V3	Q921I6
RefSeq (mRNA)	NM_014521	NM_133816
RefSeq (protein)	NP_055336 NP_001358231 NP_001358232 NP_001358233 NP_001358234 NP_001358235	NP_598577
Location (UCSC)	Chr 2: 234.95 – 235.06 Mb	Chr 1: 89.07 – 89.16 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

This gene encodes a protein with 3 Asn-Pro-Phe (NPF) motifs, an SH3 domain, a PXXP motif, a bipartite nuclear targeting signal, and a tyrosine phosphorylation site. This protein is involved in cargo-specific control of clathrin-mediated endocytosis, specifically controlling the internalization of a specific protein receptor.[6]

References

1. GRCh38: Ensembl release 89: ENSG00000130147 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000036206 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Dunlevy JR, Berryhill BL, Vergnes JP, SundarRaj N, Hassell JR (Mar 2000). "Cloning, chromosomal localization, and characterization of cDNA from a novel gene, SH3BP4, expressed by human corneal fibroblasts". Genomics. 62 (3): 519–24. doi:10.1006/geno.1999.5994. PMID 10644451.
6. "Entrez Gene: SH3BP4 SH3-domain binding protein 4".

Further reading

• Wong WT, Schumacher C, Salcini AE, et al. (1995). "A protein-binding domain, EH, identified in the receptor tyrosine kinase substrate Eps15 and conserved in evolution". Proc. Natl. Acad. Sci. U.S.A. 92 (21): 9530–4. doi:10.1073/pnas.92.21.9530. PMC 40835. PMID 7568168.
• Salcini AE, Confalonieri S, Doria M, et al. (1997). "Binding specificity and in vivo targets of the EH domain, a novel protein-protein interaction module". Genes Dev. 11 (17): 2239–49. doi:10.1101/gad.11.17.2239. PMC 275390. PMID 9303539.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Jin J, Smith FD, Stark C, et al. (2004). "Proteomic, functional, and domain-based analysis of in vivo 14-3-3 binding proteins involved in cytoskeletal regulation and cellular organization". Curr. Biol. 14 (16): 1436–50. doi:10.1016/j.cub.2004.07.051. PMID 15324660.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Khanobdee K, Kolberg JB, Dunlevy JR (2005). "Nuclear and plasma membrane localization of SH3BP4 in retinal pigment epithelial cells". Mol. Vis. 10: 933–42. PMID 15616480.
• Benzinger A, Muster N, Koch HB, et al. (2005). "Targeted proteomic analysis of 14-3-3 sigma, a p53 effector commonly silenced in cancer". Mol. Cell. Proteomics. 4 (6): 785–95. doi:10.1074/mcp.M500021-MCP200. PMID 15778465.
• Hillier LW, Graves TA, Fulton RS, et al. (2005). "Generation and annotation of the DNA sequences of human chromosomes 2 and 4". Nature. 434 (7034): 724–31. doi:10.1038/nature03466. PMID 15815621.
• Tosoni D, Puri C, Confalonieri S, et al. (2006). "TTP specifically regulates the internalization of the transferrin receptor". Cell. 123 (5): 875–88. doi:10.1016/j.cell.2005.10.021. PMID 16325581.
• Beausoleil SA, Villén J, Gerber SA, et al. (2006). "A probability-based approach for high-throughput protein phosphorylation analysis and site localization". Nat. Biotechnol. 24 (10): 1285–92. doi:10.1038/nbt1240. PMID 16964243.
• Ewing RM, Chu P, Elisma F, et al. (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry". Mol. Syst. Biol. 3 (1): 89. doi:10.1038/msb4100134. PMC 1847948. PMID 17353931.