SFRS2

Splicing factor, arginine/serine-rich 2 is a protein that in humans is encoded by the SFRS2 gene.[5][6][7]

SRSF2
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesSRSF2, PR264, SC-35, SC35, SFRS2, SFRS2A, SRp30b, serine/arginine-rich splicing factor 2, serine and arginine rich splicing factor 2
External IDsOMIM: 600813 MGI: 98284 HomoloGene: 37721 GeneCards: SRSF2
Gene location (Human)
Chr.Chromosome 17 (human)[1]
Band17q25.1Start76,734,115 bp[1]
End76,737,374 bp[1]
RNA expression pattern




More reference expression data
Orthologs
SpeciesHumanMouse
Entrez

6427

20382

Ensembl

ENSG00000161547

ENSMUSG00000034120

UniProt

Q01130

Q62093

RefSeq (mRNA)

NM_001195427
NM_003016

NM_011358

RefSeq (protein)

NP_001182356
NP_003007

NP_035488

Location (UCSC)Chr 17: 76.73 – 76.74 MbChr 11: 116.85 – 116.85 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Interactions

SFRS2 has been shown to interact with CDC5L[8] and ASF/SF2.[9]

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gollark: > Haskell
gollark: Check Hoogle.
gollark: So does `$!!`, `:$$:`, `<&>`, `:|>` and `|*><*|`.
gollark: `^^%^^` ships with GHC.

References

  1. GRCh38: Ensembl release 89: ENSG00000161547 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000034120 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Bermingham JR, Arden KC, Naumova AK, Sapienza C, Viars CS, Fu XD, Khotz J, Manley JL, Rosenfeld MG (September 1995). "Chromosomal localization of mouse and human genes encoding the splicing factors ASF/SF2 (SFRS1) and SC-35 (SFRS2)". Genomics. 29 (1): 70–9. doi:10.1006/geno.1995.1216. PMID 8530103.
  6. Fu XD, Maniatis T (April 1992). "Isolation of a complementary DNA that encodes the mammalian splicing factor SC35". Science. 256 (5056): 535–8. doi:10.1126/science.1373910. PMID 1373910.
  7. "Entrez Gene: SFRS2 splicing factor, arginine/serine-rich 2".
  8. Ajuh P, Kuster B, Panov K, Zomerdijk JC, Mann M, Lamond AI (December 2000). "Functional analysis of the human CDC5L complex and identification of its components by mass spectrometry". The EMBO Journal. 19 (23): 6569–81. doi:10.1093/emboj/19.23.6569. PMC 305846. PMID 11101529.
  9. Zhang WJ, Wu JY (October 1996). "Functional properties of p54, a novel SR protein active in constitutive and alternative splicing". Molecular and Cellular Biology. 16 (10): 5400–8. doi:10.1128/MCB.16.10.5400. PMC 231539. PMID 8816452.

Further reading

  • Overview of all the structural information available in the PDB for UniProt: Q01130 (Serine/arginine-rich splicing factor 2) at the PDBe-KB.
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