Robert Vince (scientist)

Robert Vince (born November 20, 1940) is an American scientist known for his contributions to the research in the area of drug design. He is currently the Director and Professor at the Center for Drug Design at the Academic Health Center for the University of Minnesota.

Robert Vince
BornNovember 20, 1940 (1940-11-20) (age 79)
Auburn, New York
Alma materSUNY, Buffalo, New York
Known forAbacavir, Vince Lactam, Carbovir, Acyclovir

Biography

Robert Vince was born in Auburn, New York. After graduating with a Bachelor of Science in Pharmacy in 1962, Vince joined the research group of Prof Howard J. Schaeffer at SUNY Buffalo in New York, where he obtained his doctoral degree in medicinal chemistry. He subsequently joined the University of Mississippi for a brief stint as Assistant Professor of medicinal chemistry. In 1967, he joined the medicinal chemistry faculty at the University of Minnesota.[1] In 2002, Vince established the Center for Drug Design within the Academic Health Center of the University of Minnesota, where he continues as director and maintains his research program.[2]

Career Contributions

As a graduate student, Vince’s research on the design of acyclonucleosides, with Howard J. Schaeffer at SUNY Buffalo became an integral part of the discovery of anti-viral drug acyclovir.[3] Later, Prof Schaeffer continued the development of acyclovir at Burroughs Welcome & Company, with pharmacologist Gertrude B. Elion who was awarded the 1988 Nobel Prize in Medicine, in part, for the development of acyclovir.[4] Dr. Vince continued his work on antiviral drug candidates at the University of Minnesota, where he went on to develop carbocyclic nucleosides termed 'carbovirs'. This class of medicinal agents included the drug abacavir.[5] Abacavir was commercialized by GlaxoSmithKline as Ziagen® for the treatment of AIDS. Sales from Ziagen® have resulted in generation of more than 600 million US dollars in royalties for the University of Minnesota.[1]

His synthesis of abacavir made use of a bicyclic γ-lactam, 2-azabicyclo[2.2.1]hept-5-en-3-one, as a chemical precursor. In recognition of his contribution to the development of this field, Chemical and Engineering News gave this molecule a general name, ‘Vince lactam’ in 2003.[6] Vince lactam has since been utilized to prepare several drugs and pharmaceutical candidates.[1]

Recognition

For his work, Vince has received recognition from several avenues. He was elected as the Fellow of AAAS by The American Association for the Advancement of Science in 2000.[7] He was inducted into the Medicinal Chemistry Hall of Fame of the American Chemical Society in 2007.[8] Vince was awarded Honorary Doctorate of Science Degree by his alma mater SUNY Buffalo,[9] and the prestigious Imbach Townsend Award by the International Society for Nucleosides, Nucleotides and Nucleic Acids, in 2010.[10] The same year, Minnesota Inventor’s Congress inducted him into Minnesota Inventors Hall of Fame, along with Nobel laureate Dr. Norman Borlaug (posthumously).[11] In 2011, he was inducted into Minnesota Science & Technology Hall of Fame.[12] In 2017, the New York State Senate adopted a legislative resolution commending him upon the occasion of his designation as a 2017 Inductee into the Auburn Alumni Hall of Distinction.[13] Recently, he was honored at the National Academy of Inventors (NAI) 2018 Annual Conference as an NAI Fellow.[14]

  • May 2018: Honored with National Academy of Inventors' Fellow status, Houston, TX[14]
  • April 2017: New York State Senate resolution K281, NY[13]
  • March 2014: Charles W. Hartman Memorial Lecture - 2014, University of Mississippi, MS[15]
  • February 2013: David Chu Lectureship – 2013, University of Georgia, GA[16]
  • November 2011: Inducted into Minnesota Science & Technology Hall of Fame[12]
  • September 2010: Inducted into Minnesota Inventors Hall of Fame, along with Nobel laureate Dr. Norman Borlaug (posth.), by the Minnesota Inventor’s Congress[11]
  • August 2010: Received 2010 Imbach Townsend Award from the International Society for Nucleosides, Nucleotides and Nucleic Acids[10]
  • April 2010: Received Honorary Doctorate of Science Degree from SUNY Buffalo[9]
  • September 2009: Elected to the University of Minnesota’s AHC Academy of Excellence in Health Research[17]
  • August 2007: Inducted into ACS Medicinal Chemistry Hall of Fame[8]
  • 2006: Recognized on ‘Scholars Walk and Wall of Discovery’ at the University of Minnesota[18]
  • 2000: Elected as Fellow of AAAS by The American Association for the Advancement of Science[7]
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References
  1. Singh, R.; Vince, R. “2-Azabicyclo[2.2.1]hept-5-en-3-one: Chemical Profile of a Versatile Synthetic Building Block and its Impact on the Development of Therapeutics" Chemical Reviews 2012, 112, 4642–4686.
  2. "About Center For Drug Design".
  3. Howard Schaeffer, S. Bittner, Robert Vince, S. Gurwara "Novel substrate of adenosine deaminase". Journal of Medicinal Chemistry 1971, 14, 367–369.
  4. "The Nobel Prize in Physiology or Medicine 1988".
  5. Vince, R. "A brief history of the development of Ziagen" Chemtracts 2008, 21, 127–134.
  6. Rouhi, M. Chem. Eng. News 2003, 81, 40.
  7. "The American Association for the Advancement of Science: News and Notes October 2000" (PDF).
  8. "ACS Medicinal Chemistry Hall of Fame - Robert Vince, PhD".
  9. "Four to Receive SUNY Honorary Degrees at UB".
  10. "International Society for Nucleosides, Nucleotides and Nucleic Acids 2010 Imbach Townsend Award" (PDF).
  11. "Dr. Robert Vince - 2010 Inductee Minnesota Inventors Hall of Fame".
  12. "Robert Vince: How he has transformed the scene".
  13. "Resolution# K281". NY State Senate. 2017-04-03. Retrieved 2019-06-03.
  14. "U Inventor Robert Vince Honored as NAI Fellow". Inquiry | Office of the Vice President for Research. 2018-05-29. Retrieved 2019-06-03.
  15. "Designer of HIV Drug Abacavir to Give UM Hartman Lecture".
  16. "Minnesota's Center for Drug Design director to give annual Chu Lecture at UGA".
  17. "Academy for Excellence in Health Research - 2009 Inductees".
  18. "University of Minnesota Scholar's Walk: Who's on the Wall".
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