RPL22L1

Ribosomal protein L22 like 1 (RPL22L1), or eL22L1, is a protein that in humans is encoded by the RPL22L1 gene. [3]

RPL22L1
Identifiers
AliasesRPL22L1, ribosomal protein L22 like 1
External IDsHomoloGene: 134069 GeneCards: RPL22L1
Gene location (Human)
Chr.Chromosome 3 (human)[1]
Band3q26.2Start170,864,875 bp[1]
End170,870,208 bp[1]
Orthologs
SpeciesHumanMouse
Entrez

200916

n/a

Ensembl

ENSG00000163584

n/a

UniProt

Q6P5R6

n/a

RefSeq (mRNA)

NM_001099645
NM_001320451

n/a

RefSeq (protein)

NP_001093115
NP_001307380

n/a

Location (UCSC)Chr 3: 170.86 – 170.87 Mbn/a
PubMed search[2]n/a
Wikidata
View/Edit Human

Function

eL22L1 is a ribosomal protein paralog of the eL22 protein of the 60S ribosomal subunit. This paralog is divergent from the normal copy, and is expressed when the normal copy is deleted from mice.[4] This compensation implies a ribosome function similar to the normal copy, though eL22L1 has also been implicates in other extraribosomal roles including pre-mRNA splicing regulation in zebrafish.[5]

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See also

References
  1. GRCh38: Ensembl release 89: ENSG00000163584 - Ensembl, May 2017
  2. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  3. "Entrez Gene: Ribosomal protein L22 like 1". Retrieved 2019-12-03.
  4. O'Leary MN, Schreiber KH, Zhang Y, Duc AC, Rao S, Hale JS, et al. (2013-08-22). Copenhaver GP (ed.). "The ribosomal protein Rpl22 controls ribosome composition by directly repressing expression of its own paralog, Rpl22l1". PLoS Genetics. Public Library of Science (PLoS). 9 (8): e1003708. doi:10.1371/journal.pgen.1003708. PMID 23990801.
  5. Zhang Y, O'Leary MN, Peri S, Wang M, Zha J, Melov S, et al. (January 2017). "Ribosomal Proteins Rpl22 and Rpl22l1 Control Morphogenesis by Regulating Pre-mRNA Splicing". Cell Reports. Elsevier BV. 18 (2): 545–556. doi:10.1016/j.celrep.2016.12.034. PMID 28076796.
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