Proning

Proning or prone positioning is the placement of patients into a prone position so that they are lying on their stomach. This is used in the treatment of patients in intensive care with acute respiratory distress syndrome (ARDS). It has been especially tried and studied for patients on ventilators but, during the COVID-19 pandemic, it is being used for patients with oxygen masks and CPAP as an alternative to ventilation.[1][2]

A newborn baby placed in prone position with electrical impedance tomography electrodes to assess the effect on lung ventilation

Intensive care

Prone positioning may be used for people suffering from acute respiratory distress syndrome (ARDS) to improve their breathing. If the patient is undergoing intensive care and sedated then this is a difficult procedure because lifting and turning the unconscious patient requires many staff or special equipment. If they are intubated then care has to be taken to manage the tangle of associated lines and tubes.[3]

A 2011 meta-analysis of 48 studies found that there were no negative effects on mortality for patients in intensive care but that a significant reduction in mortality was only found with those patients who were severely ill with ARDS.[4]

A 2012 systematic review of 53 studies of proning in infants with acute respiratory distress found that it was effective in improving oxygenation. No adverse effects were found but the risk of sudden infant death syndrome, which is greater in the prone position, necessitates continuous monitoring.[5]

A 2014 systematic review of 11 trials found that reduction of the tidal volume of ventilation, in combination with prone positioning, was effective, saving the life of about one additional patient in eleven.[6]

The Large Observational Study to UNderstand the Global Impact of Severe Acute Respiratory FailurE (LUNG-SAFE) conducted by the European Society of Intensive Care Medicine (ESICM) looked at the use of proning during the study period of 2014. At that time, proning was used for 7% of all ARDS patients and 14% of the most severe cases.[7] The ESICM and Surviving Sepsis Campaign published Guidelines on the Management of Critically Ill Adults with Coronavirus Disease 2019 (COVID-19) in 2020.[8] These recommended the use of proning:[9]

For mechanically ventilated adults with COVID-19 and moderate to severe ARDS, we suggest prone ventilation for 12 to 16 hours, over no prone ventilation (weak recommendation, low quality evidence).

In the COVID-19 pandemic, there is anecdotal evidence in areas such as New York, that prone or reclining posture can be used with oxygen supplied by a mask or continuous positive airway pressure (CPAP) to improve oxygenation and so avoid the need for intubation and ventilation. This especially effective with heavy, obese patients who suffer more on their back in a supine position.[1] In April 2020, the Intensive Care Society issued guidelines for the use of prone positioning with conscious COVID sufferers, recommending that it be tried for all suitable patients. [10]

Mechanisms

There are several factors which have been suggested to explain the benefits of this position for ARDS patients. These include

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See also

References
  1. Jim Dwyer (14 April 2020), "What Doctors on the Front Lines Wish They'd Known a Month Ago", New York Times, The biggest change: Instead of quickly sedating people who had shockingly low levels of oxygen and then putting them on mechanical ventilators, many doctors are now keeping patients conscious, having them roll over in bed, recline in chairs and continue to breathe on their own — with additional oxygen — for as long as possible.
  2. Kat Lay (16 April 2020), "'Proning' could keep coronavirus patients out of intensive care", The Times
  3. "Prone positioning", Nursing Procedures and Protocols, Lippincott Williams & Wilkins, pp. 351–355, 2003, ISBN 9781582552378
  4. Abroug, F.; Ouanes-Besbes, L.; Dachraoui, F. (2011), "An updated study-level meta-analysis of randomised controlled trials on proning in ARDS and acute lung injury", Critical Care (15), doi:10.1186/cc9403
  5. Gillies, Donna; Wells, Deborah; Bhandari, Abhishta P (11 July 2012), "Positioning for acute respiratory distress in hospitalised infants and children", Cochrane Database of Systematic Reviews (7): CD003645, doi:10.1002/14651858.CD003645.pub3, PMC 7144689, PMID 22786486
  6. Sud S; Friedrich JO; Adhikari NK (8 July 2014), "Effect of prone positioning during mechanical ventilation on mortality among patients with acute respiratory distress syndrome: a systematic review and meta-analysis", Canadian Medical Association Journal, 186 (10): E381–390, doi:10.1503/cmaj.140081, PMC 4081236, PMID 24863923
  7. Guérin, Claude (2017), "Prone position", in Davide Chiumello (ed.), Acute Respiratory Distress Syndrome, Springer, pp. 73–84, ISBN 9783319418520
  8. Liam Davenport (31 March 2020), Top 10 Must-Dos in ICU in COVID-19 Include Prone Ventilation, Medscape
  9. Waleed Alhazzani1; et al. (2020), "Surviving Sepsis Campaign: Guidelines on the Management of Critically Ill Adults with Coronavirus Disease 2019 (COVID-19)" (PDF), Intensive Care Medicine and Critical Care Medicine, doi:10.1007/s00134-020-06022-5
  10. Peter Bamford; Andrew Bentley; 3Jane Dean; David Whitmore; Noamaan Wilson-Baig (2020), ICS Guidance for Prone Positioning of the Conscious COVID Patient 2020 (PDF), Intensive Care Society
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