Plasma cell granuloma

Plasma cell granuloma is a lesional pattern of inflammatory pseudotumour, different from the "inflammatory myofibroblastic tumor" pattern.

It is linked to IgG4-related disease.[1]

Pathology

Histologically, the lesions consisted of a proliferation of mature plasma cells and reticulo-endothelial cells supported by a stroma of granulation tissue, with varying degrees of myxoid change or collagenization. Angioinvasion within the lesion is observed in 50% of cases.[2]

Immunohistochemical staining reveals the IgG-predominant polyclonal nature of the plasma cells, indicating a reactive inflammatory process rather than a neoplastic one.

Electron microscopy confirms the benign nature of the plasma cells with fibroblast and myofibroblast proliferation admixed with that of other inflammatory cells.

Localization
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See also

References
  1. Dias, O. M.; Kawassaki Ade, M; Haga, H; Cukier, A; Carvalho, C. R. (2011). "Immunoglobulin G4-related systemic sclerosing disease in a patient with sclerosing cholangitis, inflammatory pseudotumors of the lung and multiple radiological patterns: A case report". Clinics (Sao Paulo, Brazil). 66 (11): 1983–6. doi:10.1590/s1807-59322011001100021. PMC 3203974. PMID 22086532.
  2. Nonomura, A; Mizukami, Y; Matsubara, F; Shimizu, J; Oda, M; Watanabe, Y; Kamimura, R; Takashima, T; Kitagawa, M (1992). "Seven patients with plasma cell granuloma (inflammatory pseudotumor) of the lung, including two with intrabronchial growth: An immunohistochemical and electron microscopic study". Internal Medicine (Tokyo, Japan). 31 (6): 756–65. doi:10.2169/internalmedicine.31.756. PMID 1392177.
  3. Nonomura, A; Mizukami, Y; Matsubara, F; Shimizu, J; Oda, M; Watanabe, Y; Kamimura, R; Takashima, T; Kitagawa, M (1992). "Seven patients with plasma cell granuloma (inflammatory pseudotumor) of the lung, including two with intrabronchial growth: An immunohistochemical and electron microscopic study". Internal Medicine (Tokyo, Japan). 31 (6): 756–65. doi:10.2169/internalmedicine.31.756. PMID 1392177.
  4. Balachandran, A; Shivbalan, S (2004). "Plasma cell granuloma of the lung". Indian Pediatrics. 41 (3): 292–3. PMID 15064526.


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