Liprin-alpha-1

Liprin-alpha-1 is a protein that in humans is encoded by the PPFIA1 gene.[5][6][7]

PPFIA1
Available structures PDB Human UniProt search: PDBe RCSB List of PDB id codes 1N7F
Identifiers
Aliases	PPFIA1, LIP.1, LIP1, LIPRIN, PTPRF interacting protein alpha 1
External IDs	OMIM: 611054 MGI: 1924750 HomoloGene: 20802 GeneCards: PPFIA1
Gene location (Human) Chr. Chromosome 11 (human)[1] Band 11q13.3 Start 70,270,700 bp[1] End 70,385,312 bp[1]
Gene location (Mouse) Chr. Chromosome 7 (mouse)[2] Band 7|7 F5 Start 144,476,758 bp[2] End 144,553,729 bp[2]
RNA expression pattern More reference expression data
Gene ontology Molecular function • GO:0001948 protein binding • signal transducer activity Cellular component • presynaptic active zone • focal adhesion • cytoplasm • cytosol • axon • dendrite • macromolecular complex Biological process • cell-matrix adhesion • negative regulation of stress fiber assembly • signal transduction • negative regulation of protein localization to plasma membrane • GO:0010554 neurotransmitter secretion • glutamate secretion Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	8500	233977
Ensembl	ENSG00000131626	ENSMUSG00000037519
UniProt	Q13136	n/a
RefSeq (mRNA)	NM_003626 NM_177423 NM_001378006	NM_001033319 NM_001195086
RefSeq (protein)	NP_003617 NP_803172 NP_001364935	n/a
Location (UCSC)	Chr 11: 70.27 – 70.39 Mb	Chr 7: 144.48 – 144.55 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

Function

The protein encoded by this gene is a member of the LAR protein tyrosine phosphatase-interacting protein (liprin) family. Liprins interact with members of LAR family of transmembrane protein tyrosine phosphatases, which are known to be important for axon guidance and mammary gland development. This protein binds to the intracellular membrane-distal phosphatase domain of tyrosine phosphatase LAR, and appears to localize LAR to cell focal adhesions. This interaction may regulate the disassembly of focal adhesion and thus help orchestrate cell-matrix interactions. Alternatively spliced transcript variants encoding distinct isoforms have been described.[7]

Interactions

Protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 1 has been shown to interact with:

• ERC2,[8]
• GIT1,[8][9]
• GRIP2,[8][9]
• PPFIBP1,[6]
• PPP2R5D,[10]
• PTPRD,[11]
• PTPRF,[5][6][11] and
• PTPRS.[6][11]

References

1. GRCh38: Ensembl release 89: ENSG00000131626 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000037519 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Serra-Pagès C, Kedersha NL, Fazikas L, Medley Q, Debant A, Streuli M (Aug 1995). "The LAR transmembrane protein tyrosine phosphatase and a coiled-coil LAR-interacting protein co-localize at focal adhesions". EMBO J. 14 (12): 2827–2838. doi:10.1002/j.1460-2075.1995.tb07282.x. PMC 398401. PMID 7796809.
6. Serra-Pagès C, Medley QG, Tang M, Hart A, Streuli M (Jul 1998). "Liprins, a family of LAR transmembrane protein-tyrosine phosphatase-interacting proteins". J Biol Chem. 273 (25): 15611–15620. doi:10.1074/jbc.273.25.15611. PMID 9624153.
7. "Entrez Gene: PPFIA1 protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 1".
8. Ko J, Na M, Kim S, Lee JR, Kim E (Oct 2003). "Interaction of the ERC family of RIM-binding proteins with the liprin-alpha family of multidomain proteins". J. Biol. Chem. 278 (43): 42377–85. doi:10.1074/jbc.M307561200. PMID 12923177.
9. Ko J, Kim S, Valtschanoff JG, Shin H, Lee JR, Sheng M, Premont RT, Weinberg RJ, Kim E (Mar 2003). "Interaction between liprin-alpha and GIT1 is required for AMPA receptor targeting". J. Neurosci. 23 (5): 1667–77. doi:10.1523/JNEUROSCI.23-05-01667.2003. PMC 6741975. PMID 12629171.
10. Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M (Oct 2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.
11. Pulido R, Serra-Pagès C, Tang M, Streuli M (Dec 1995). "The LAR/PTP delta/PTP sigma subfamily of transmembrane protein-tyrosine-phosphatases: multiple human LAR, PTP delta, and PTP sigma isoforms are expressed in a tissue-specific manner and associate with the LAR-interacting protein LIP.1". Proc. Natl. Acad. Sci. U.S.A. 92 (25): 11686–90. doi:10.1073/pnas.92.25.11686. PMC 40467. PMID 8524829.

Further reading

• Pulido R, Serra-Pagès C, Tang M, Streuli M (1996). "The LAR/PTP delta/PTP sigma subfamily of transmembrane protein-tyrosine-phosphatases: multiple human LAR, PTP delta, and PTP sigma isoforms are expressed in a tissue-specific manner and associate with the LAR-interacting protein LIP.1". Proc. Natl. Acad. Sci. U.S.A. 92 (25): 11686–11690. doi:10.1073/pnas.92.25.11686. PMC 40467. PMID 8524829.
• Wyszynski M, Kim E, Dunah AW, Passafaro M, Valtschanoff JG, Serra-Pagès C, Streuli M, Weinberg RJ, Sheng M (2002). "Interaction between GRIP and liprin-alpha/SYD2 is required for AMPA receptor targeting". Neuron. 34 (1): 39–52. doi:10.1016/S0896-6273(02)00640-2. PMID 11931740.
• Ko J, Kim S, Valtschanoff JG, Shin H, Lee JR, Sheng M, Premont RT, Weinberg RJ, Kim E (2003). "Interaction between liprin-alpha and GIT1 is required for AMPA receptor targeting". J. Neurosci. 23 (5): 1667–1677. doi:10.1523/JNEUROSCI.23-05-01667.2003. PMID 12629171.
• Ko J, Na M, Kim S, Lee JR, Kim E (2004). "Interaction of the ERC family of RIM-binding proteins with the liprin-alpha family of multidomain proteins". J. Biol. Chem. 278 (43): 42377–42385. doi:10.1074/jbc.M307561200. PMID 12923177.
• Jin J, Smith FD, Stark C, Wells CD, Fawcett JP, Kulkarni S, Metalnikov P, O'Donnell P, Taylor P, Taylor L, Zougman A, Woodgett JR, Langeberg LK, Scott JD, Pawson T (2004). "Proteomic, functional, and domain-based analysis of in vivo 14-3-3 binding proteins involved in cytoskeletal regulation and cellular organization". Curr. Biol. 14 (16): 1436–1450. doi:10.1016/j.cub.2004.07.051. PMID 15324660.
• Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–1178. doi:10.1038/nature04209. PMID 16189514.
• Serra-Pagès C, Streuli M, Medley QG (2006). "Liprin phosphorylation regulates binding to LAR: evidence for liprin autophosphorylation". Biochemistry. 44 (48): 15715–15724. doi:10.1021/bi051434f. PMC 2529169. PMID 16313174.
• Lim J, Hao T, Shaw C, Patel AJ, Szabó G, Rual JF, Fisk CJ, Li N, Smolyar A, Hill DE, Barabási AL, Vidal M, Zoghbi HY (2006). "A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration". Cell. 125 (4): 801–814. doi:10.1016/j.cell.2006.03.032. PMID 16713569.
• Olsen JV, Blagoev B, Gnad F, Macek B, Kumar C, Mortensen P, Mann M (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–648. doi:10.1016/j.cell.2006.09.026. PMID 17081983.
• Hoogenraad CC, Feliu-Mojer MI, Spangler SA, Milstein AD, Dunah AW, Hung AY, Sheng M (2007). "Liprinalpha1 degradation by calcium/calmodulin-dependent protein kinase II regulates LAR receptor tyrosine phosphatase distribution and dendrite development". Dev. Cell. 12 (4): 587–602. doi:10.1016/j.devcel.2007.02.006. PMID 17419996.

External links

• Overview of all the structural information available in the PDB for UniProt: Q13136 (Liprin-alpha-1) at the PDBe-KB.