ERC2 (gene)

ERC2
Identifiers
Aliases	ERC2, CAST, CAST1, ELKSL, SPBC110, Spc110, ELKS/RAB6-interacting/CAST family member 2
External IDs	OMIM: 617250 MGI: 1098749 HomoloGene: 69188 GeneCards: ERC2
Gene location (Human)
Chr.	Chromosome 3 (human)[1]
End	56,468,467 bp[1]
Gene location (Mouse)
Chr.	Chromosome 14 (mouse)[2]
End	28,478,537 bp[2]
RNA expression pattern
	More reference expression data
Gene ontology
Molecular function	• GO:0001948 protein binding; • structural constituent of presynaptic active zone;
Cellular component	• cytoplasm; • growth cone; • presynaptic active zone; • neuron projection; • cell junction; • synapse; • cytoskeleton; • presynaptic membrane; • presynaptic active zone cytoplasmic component; • glutamatergic synapse; • GABA-ergic synapse;
Biological process	• synaptic vesicle priming; • maintenance of presynaptic active zone structure;
	Sources:Amigo / QuickGO
Orthologs
	26059
	238988
	ENSG00000187672
	ENSMUSG00000040640
	O15083
	Q6PH08
	NM_015576
	NM_177814; NM_001347497
	NP_056391
	NP_001334426; NP_808482
	Wikidata
View/Edit Human	View/Edit Mouse

ERC protein 2 is a protein that in humans is encoded by the ERC2 gene.[5]

Interactions

ERC2 (gene) has been shown to interact with PPFIA4,[6] RIMS1,[7][8] UNC13A,[9] and liprin-alpha-1.[6]

gollark: There are probably some things where you need the most CPU power per server - big database servers which aren't horizontally scaleable, video encoding, whatever - but I don't think that's the majority of use.

gollark: IIRC lots are already having issues with the high power of recent server CPU generations.

gollark: Most customers want to maximize compute per *rack*, not per server.

gollark: I can't see this actually being very useful outside of weirdly specific scenarios, honestly.

gollark: It's only 50% more cores than previously. And the chiplet-y design is meant to make it easy to shove extra cores on if you don't care about power much.

References

GRCh38: Ensembl release 89: ENSG00000187672 - Ensembl, May 2017
GRCm38: Ensembl release 89: ENSMUSG00000040640 - Ensembl, May 2017
"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
"Entrez Gene: ERC2 ELKS/RAB6-interacting/CAST family member 2".
Ko J, Na M, Kim S, Lee JR, Kim E (October 2003). "Interaction of the ERC family of RIM-binding proteins with the liprin-alpha family of multidomain proteins". The Journal of Biological Chemistry. 278 (43): 42377–85. doi:10.1074/jbc.M307561200. PMID 12923177.
Takao-Rikitsu E, Mochida S, Inoue E, Deguchi-Tawarada M, Inoue M, Ohtsuka T, Takai Y (January 2004). "Physical and functional interaction of the active zone proteins, CAST, RIM1, and Bassoon, in neurotransmitter release". The Journal of Cell Biology. 164 (2): 301–11. doi:10.1083/jcb.200307101. PMC 2172332. PMID 14734538.
Ohtsuka T, Takao-Rikitsu E, Inoue E, Inoue M, Takeuchi M, Matsubara K, Deguchi-Tawarada M, Satoh K, Morimoto K, Nakanishi H, Takai Y (August 2002). "Cast: a novel protein of the cytomatrix at the active zone of synapses that forms a ternary complex with RIM1 and munc13-1". The Journal of Cell Biology. 158 (3): 577–90. doi:10.1083/jcb.200202083. PMC 2173811. PMID 12163476.
"Protein unc-13 homolog A". UniProt.

Nakajima D, Okazaki N, Yamakawa H, Kikuno R, Ohara O, Nagase T (June 2002). "Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones". DNA Research. 9 (3): 99–106. CiteSeerX 10.1.1.500.923. doi:10.1093/dnares/9.3.99. PMID 12168954.
Nagase T, Ishikawa K, Nakajima D, Ohira M, Seki N, Miyajima N, Tanaka A, Kotani H, Nomura N, Ohara O (April 1997). "Prediction of the coding sequences of unidentified human genes. VII. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro". DNA Research. 4 (2): 141–50. doi:10.1093/dnares/4.2.141. PMID 9205841.
Ohtsuka T, Takao-Rikitsu E, Inoue E, Inoue M, Takeuchi M, Matsubara K, Deguchi-Tawarada M, Satoh K, Morimoto K, Nakanishi H, Takai Y (August 2002). "Cast: a novel protein of the cytomatrix at the active zone of synapses that forms a ternary complex with RIM1 and munc13-1". The Journal of Cell Biology. 158 (3): 577–90. doi:10.1083/jcb.200202083. PMC 2173811. PMID 12163476.
Wang Y, Liu X, Biederer T, Südhof TC (October 2002). "A family of RIM-binding proteins regulated by alternative splicing: Implications for the genesis of synaptic active zones". Proceedings of the National Academy of Sciences of the United States of America. 99 (22): 14464–9. doi:10.1073/pnas.182532999. PMC 137906. PMID 12391317.
Ko J, Na M, Kim S, Lee JR, Kim E (October 2003). "Interaction of the ERC family of RIM-binding proteins with the liprin-alpha family of multidomain proteins". The Journal of Biological Chemistry. 278 (43): 42377–85. doi:10.1074/jbc.M307561200. PMID 12923177.
Deguchi-Tawarada M, Inoue E, Takao-Rikitsu E, Inoue M, Ohtsuka T, Takai Y (January 2004). "CAST2: identification and characterization of a protein structurally related to the presynaptic cytomatrix protein CAST". Genes to Cells. 9 (1): 15–23. doi:10.1111/j.1356-9597.2004.00697.x. PMID 14723704.
Takao-Rikitsu E, Mochida S, Inoue E, Deguchi-Tawarada M, Inoue M, Ohtsuka T, Takai Y (January 2004). "Physical and functional interaction of the active zone proteins, CAST, RIM1, and Bassoon, in neurotransmitter release". The Journal of Cell Biology. 164 (2): 301–11. doi:10.1083/jcb.200307101. PMC 2172332. PMID 14734538.
tom Dieck S, Altrock WD, Kessels MM, Qualmann B, Regus H, Brauner D, Fejtová A, Bracko O, Gundelfinger ED, Brandstätter JH (February 2005). "Molecular dissection of the photoreceptor ribbon synapse: physical interaction of Bassoon and RIBEYE is essential for the assembly of the ribbon complex". The Journal of Cell Biology. 168 (5): 825–36. doi:10.1083/jcb.200408157. PMC 2171818. PMID 15728193.

This article is issued from Wikipedia. The text is licensed under Creative Commons - Attribution - Sharealike. Additional terms may apply for the media files.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000187672 - Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000040640 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] "Entrez Gene: ERC2 ELKS/RAB6-interacting/CAST family member 2".

[pmid12923177-6] Ko J, Na M, Kim S, Lee JR, Kim E (October 2003). "Interaction of the ERC family of RIM-binding proteins with the liprin-alpha family of multidomain proteins". The Journal of Biological Chemistry. 278 (43): 42377–85. doi:10.1074/jbc.M307561200. PMID 12923177.

[pmid14734538-7] Takao-Rikitsu E, Mochida S, Inoue E, Deguchi-Tawarada M, Inoue M, Ohtsuka T, Takai Y (January 2004). "Physical and functional interaction of the active zone proteins, CAST, RIM1, and Bassoon, in neurotransmitter release". The Journal of Cell Biology. 164 (2): 301–11. doi:10.1083/jcb.200307101. PMC 2172332. PMID 14734538.

[pmid12163476-8] Ohtsuka T, Takao-Rikitsu E, Inoue E, Inoue M, Takeuchi M, Matsubara K, Deguchi-Tawarada M, Satoh K, Morimoto K, Nakanishi H, Takai Y (August 2002). "Cast: a novel protein of the cytomatrix at the active zone of synapses that forms a ternary complex with RIM1 and munc13-1". The Journal of Cell Biology. 158 (3): 577–90. doi:10.1083/jcb.200202083. PMC 2173811. PMID 12163476.

[9] "Protein unc-13 homolog A". UniProt.

ERC2 (gene)

Interactions

References

Further reading