POLR3C

DNA-directed RNA polymerase III subunit RPC3 is an enzyme that in humans is encoded by the POLR3C gene.[5][6][7]

POLR3C
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2XUB, 2XV4, 5AFQ
Identifiers
Aliases	POLR3C, RPC3, RPC62, polymerase (RNA) III subunit C, RNA polymerase III subunit C, C82
External IDs	OMIM: 617454 MGI: 1921664 HomoloGene: 38185 GeneCards: POLR3C
Gene location (Human) Chr. Chromosome 1 (human)[1] Band 1q21.1 Start 145,824,088 bp[1] End 145,844,402 bp[1]
Gene location (Mouse) Chr. Chromosome 3 (mouse)[2] Band 3|3 F2.1 Start 96,711,490 bp[2] End 96,727,628 bp[2]
RNA expression pattern More reference expression data
Gene ontology Molecular function • DNA-directed 5'-3' RNA polymerase activity • DNA binding • GO:0001948 protein binding • RNA polymerase III activity • single-stranded DNA binding Cellular component • DNA-directed RNA polymerase III complex • cytosol • nucleoplasm • cell nucleus Biological process • positive regulation of interferon-beta production • regulation of transcription from RNA polymerase III promoter • defense response to virus • transcription, DNA-templated • positive regulation of innate immune response • immune system process • innate immune system • transcription from RNA polymerase III promoter • positive regulation of type I interferon production Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	10623	74414
Ensembl	ENSG00000186141	ENSMUSG00000028099
UniProt	Q9BUI4	Q9D483
RefSeq (mRNA)	NM_001303456 NM_006468	NM_028925
RefSeq (protein)	NP_001290385 NP_006459	NP_083201
Location (UCSC)	Chr 1: 145.82 – 145.84 Mb	Chr 3: 96.71 – 96.73 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

Interactions

POLR3C has been shown to interact with GTF3C4.[8][9]

Related gene problems

• TAR syndrome[10]
• 1q21.1 deletion syndrome
• 1q21.1 duplication syndrome

References

1. GRCh38: Ensembl release 89: ENSG00000186141 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000028099 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Wang Z, Roeder RG (May 1997). "Three human RNA polymerase III-specific subunits form a subcomplex with a selective function in specific transcription initiation". Genes & Development. 11 (10): 1315–26. doi:10.1101/gad.11.10.1315. PMID 9171375.
6. Hu P, Wu S, Sun Y, Yuan CC, Kobayashi R, Myers MP, Hernandez N (November 2002). "Characterization of human RNA polymerase III identifies orthologues for Saccharomyces cerevisiae RNA polymerase III subunits" (PDF). Molecular and Cellular Biology. 22 (22): 8044–55. doi:10.1128/MCB.22.22.8044-8055.2002. PMC 134740. PMID 12391170.
7. "Entrez Gene: POLR3C polymerase (RNA) III (DNA directed) polypeptide C (62kD)".
8. Hsieh YJ, Wang Z, Kovelman R, Roeder RG (July 1999). "Cloning and characterization of two evolutionarily conserved subunits (TFIIIC102 and TFIIIC63) of human TFIIIC and their involvement in functional interactions with TFIIIB and RNA polymerase III". Molecular and Cellular Biology. 19 (7): 4944–52. doi:10.1128/mcb.19.7.4944. PMC 84305. PMID 10373544.
9. Hsieh YJ, Kundu TK, Wang Z, Kovelman R, Roeder RG (November 1999). "The TFIIIC90 subunit of TFIIIC interacts with multiple components of the RNA polymerase III machinery and contains a histone-specific acetyltransferase activity". Molecular and Cellular Biology. 19 (11): 7697–704. doi:10.1128/mcb.19.11.7697. PMC 84812. PMID 10523658.
10. Klopocki E, Schulze H, Strauss G, Ott CE, Hall J, Trotier F, et al. (February 2007). "Complex inheritance pattern resembling autosomal recessive inheritance involving a microdeletion in thrombocytopenia-absent radius syndrome". American Journal of Human Genetics. 80 (2): 232–40. doi:10.1086/510919. PMC 1785342. PMID 17236129.

Further reading

• Jang KL, Collins MK, Latchman DS (1992). "The human immunodeficiency virus tat protein increases the transcription of human Alu repeated sequences by increasing the activity of the cellular transcription factor TFIIIC". Journal of Acquired Immune Deficiency Syndromes. 5 (11): 1142–7. PMID 1403646.
• Maruyama K, Sugano S (January 1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S (October 1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
• Hsieh YJ, Wang Z, Kovelman R, Roeder RG (July 1999). "Cloning and characterization of two evolutionarily conserved subunits (TFIIIC102 and TFIIIC63) of human TFIIIC and their involvement in functional interactions with TFIIIB and RNA polymerase III". Molecular and Cellular Biology. 19 (7): 4944–52. doi:10.1128/mcb.19.7.4944. PMC 84305. PMID 10373544.
• Hsieh YJ, Kundu TK, Wang Z, Kovelman R, Roeder RG (November 1999). "The TFIIIC90 subunit of TFIIIC interacts with multiple components of the RNA polymerase III machinery and contains a histone-specific acetyltransferase activity". Molecular and Cellular Biology. 19 (11): 7697–704. doi:10.1128/mcb.19.11.7697. PMC 84812. PMID 10523658.
• Kuwana M, Kimura K, Kawakami Y (October 2002). "Identification of an immunodominant epitope on RNA polymerase III recognized by systemic sclerosis sera: application to enzyme-linked immunosorbent assay". Arthritis and Rheumatism. 46 (10): 2742–7. doi:10.1002/art.10521. PMID 12384934.