GTF3C4

General transcription factor 3C polypeptide 4 is a protein that in humans is encoded by the GTF3C4 gene.[5][6]

GTF3C4
Identifiers
Aliases	GTF3C4, KAT12, TFIII90, TFIIIC290, TFIIIC90, TFIIICDELTA, TF3C-delta, general transcription factor IIIC subunit 4
External IDs	OMIM: 604892 MGI: 2138937 HomoloGene: 8147 GeneCards: GTF3C4
Gene location (Human) Chr. Chromosome 9 (human)[1] Band 9q34.13 Start 132,670,035 bp[1] End 132,694,953 bp[1]
Gene location (Mouse) Chr. Chromosome 2 (mouse)[2] Band 2|2 A3 Start 28,822,299 bp[2] End 28,840,360 bp[2]
RNA expression pattern More reference expression data
Gene ontology Molecular function • histone acetyltransferase activity • transferase activity • DNA binding • GO:0010577 enzyme activator activity • transferase activity, transferring acyl groups • GO:0001948 protein binding Cellular component • transcription factor TFIIIC complex • nucleoplasm • cell nucleus • mitochondrion Biological process • tRNA transcription from RNA polymerase III promoter • 5S class rRNA transcription from RNA polymerase III type 1 promoter • transcription initiation from RNA polymerase III promoter • transcription, DNA-templated • GO:0048554 positive regulation of catalytic activity • transcription from RNA polymerase III promoter • histone acetylation Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	9329	269252
Ensembl	ENSG00000125484	ENSMUSG00000035666
UniProt	Q9UKN8	Q8BMQ2
RefSeq (mRNA)	NM_012204	NM_001166033 NM_172977
RefSeq (protein)	NP_036336	NP_001159505 NP_766565
Location (UCSC)	Chr 9: 132.67 – 132.69 Mb	Chr 2: 28.82 – 28.84 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

Interactions

GTF3C4 has been shown to interact with GTF3C2,[5] GTF3C1,[5] POLR3C[5][7] and GTF3C5.[5]

References

1. GRCh38: Ensembl release 89: ENSG00000125484 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000035666 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Hsieh YJ, Kundu TK, Wang Z, Kovelman R, Roeder RG (Nov 1999). "The TFIIIC90 subunit of TFIIIC interacts with multiple components of the RNA polymerase III machinery and contains a histone-specific acetyltransferase activity". Mol. Cell. Biol. 19 (11): 7697–704. doi:10.1128/mcb.19.11.7697. PMC 84812. PMID 10523658.
6. "Entrez Gene: GTF3C4 general transcription factor IIIC, polypeptide 4, 90kDa".
7. Hsieh YJ, Wang Z, Kovelman R, Roeder RG (Jul 1999). "Cloning and characterization of two evolutionarily conserved subunits (TFIIIC102 and TFIIIC63) of human TFIIIC and their involvement in functional interactions with TFIIIB and RNA polymerase III". Mol. Cell. Biol. 19 (7): 4944–52. doi:10.1128/mcb.19.7.4944. PMC 84305. PMID 10373544.

Further reading

• Dumay-Odelot H, Marck C, Durrieu-Gaillard S, Lefebvre O, Jourdain S, Prochazkova M, Pflieger A, Teichmann M (2007). "Identification, molecular cloning, and characterization of the sixth subunit of human transcription factor TFIIIC". J. Biol. Chem. 282 (23): 17179–89. doi:10.1074/jbc.M611542200. PMID 17409385.
• Olsen JV, Blagoev B, Gnad F, Macek B, Kumar C, Mortensen P, Mann M (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983.
• Beausoleil SA, Jedrychowski M, Schwartz D, Elias JE, Villén J, Li J, Cohn MA, Cantley LC, Gygi SP (2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins". Proc. Natl. Acad. Sci. U.S.A. 101 (33): 12130–5. doi:10.1073/pnas.0404720101. PMC 514446. PMID 15302935.
• Hsieh YJ, Wang Z, Kovelman R, Roeder RG (1999). "Cloning and characterization of two evolutionarily conserved subunits (TFIIIC102 and TFIIIC63) of human TFIIIC and their involvement in functional interactions with TFIIIB and RNA polymerase III". Mol. Cell. Biol. 19 (7): 4944–52. doi:10.1128/mcb.19.7.4944. PMC 84305. PMID 10373544.
• Jang KL, Collins MK, Latchman DS (1992). "The human immunodeficiency virus tat protein increases the transcription of human Alu repeated sequences by increasing the activity of the cellular transcription factor TFIIIC". J. Acquir. Immune Defic. Syndr. 5 (11): 1142–7. PMID 1403646.