Polyamine-modulated factor 1

Polyamine-modulated factor 1 is a protein that in humans is encoded by the PMF1 gene.[5][6]

PMF1
Identifiers
Aliases	PMF1, polyamine modulated factor 1
External IDs	OMIM: 609176 MGI: 1914287 HomoloGene: 5224 GeneCards: PMF1
Gene location (Human) Chr. Chromosome 1 (human)[1] Band 1q22 Start 156,212,993 bp[1] End 156,240,042 bp[1]
Gene location (Mouse) Chr. Chromosome 3 (mouse)[2] Band 3|3 F1 Start 88,394,143 bp[2] End 88,410,331 bp[2]
Gene ontology Molecular function • GO:0001105 transcription coactivator activity • leucine zipper domain binding • GO:0001948 protein binding Cellular component • chromosome • cytosol • MIS12/MIND type complex • chromosome, centromeric region • cell nucleus • kinetochore • transcription factor complex • nucleoplasm • Golgi apparatus • intracellular membrane-bounded organelle • condensed chromosome kinetochore • nuclear MIS12/MIND complex Biological process • chromosome segregation • cell division • cell cycle • regulation of transcription, DNA-templated • transcription from RNA polymerase II promoter • transcription, DNA-templated • positive regulation of nucleic acid-templated transcription Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	11243	67037
Ensembl	ENSG00000160783	ENSMUSG00000028066
UniProt	Q6P1K2	Q9CPV5
RefSeq (mRNA)	NM_007221 NM_001199653 NM_001199654	NM_025928 NM_001310605
RefSeq (protein)	NP_001186582 NP_001186583 NP_009152	NP_001297534 NP_080204
Location (UCSC)	Chr 1: 156.21 – 156.24 Mb	Chr 3: 88.39 – 88.41 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

Interactions

Polyamine-modulated factor 1 has been shown to interact with MIS12.[7][8]

References

1. GRCh38: Ensembl release 89: ENSG00000160783 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000028066 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Wang Y, Devereux W, Stewart TM, Casero RA (July 1999). "Cloning and characterization of human polyamine-modulated factor-1, a transcriptional cofactor that regulates the transcription of the spermidine/spermine N(1)-acetyltransferase gene". The Journal of Biological Chemistry. 274 (31): 22095–101. doi:10.1074/jbc.274.31.22095. PMID 10419538.
6. "Entrez Gene: PMF1 polyamine-modulated factor 1".
7. Cheeseman IM, Niessen S, Anderson S, Hyndman F, Yates JR, Oegema K, Desai A (September 2004). "A conserved protein network controls assembly of the outer kinetochore and its ability to sustain tension". Genes & Development. 18 (18): 2255–68. doi:10.1101/gad.1234104. PMC 517519. PMID 15371340.
8. Obuse C, Iwasaki O, Kiyomitsu T, Goshima G, Toyoda Y, Yanagida M (November 2004). "A conserved Mis12 centromere complex is linked to heterochromatic HP1 and outer kinetochore protein Zwint-1". Nature Cell Biology. 6 (11): 1135–41. doi:10.1038/ncb1187. PMID 15502821.

Further reading

• Wang Y, Devereux W, Stewart TM, Casero RA (April 2001). "Characterization of the interaction between the transcription factors human polyamine modulated factor (PMF-1) and NF-E2-related factor 2 (Nrf-2) in the transcriptional regulation of the spermidine/spermine N1-acetyltransferase (SSAT) gene". The Biochemical Journal. 355 (Pt 1): 45–9. doi:10.1042/0264-6021:3550045. PMC 1221710. PMID 11256947.
• Wang Y, Devereux W, Stewart TM, Casero RA (August 2002). "Polyamine-modulated factor 1 binds to the human homologue of the 7a subunit of the Arabidopsis COP9 signalosome: implications in gene expression". The Biochemical Journal. 366 (Pt 1): 79–86. doi:10.1042/BJ20020211. PMC 1222765. PMID 12020345.
• Cheeseman IM, Niessen S, Anderson S, Hyndman F, Yates JR, Oegema K, Desai A (September 2004). "A conserved protein network controls assembly of the outer kinetochore and its ability to sustain tension". Genes & Development. 18 (18): 2255–68. doi:10.1101/gad.1234104. PMC 517519. PMID 15371340.
• Obuse C, Iwasaki O, Kiyomitsu T, Goshima G, Toyoda Y, Yanagida M (November 2004). "A conserved Mis12 centromere complex is linked to heterochromatic HP1 and outer kinetochore protein Zwint-1". Nature Cell Biology. 6 (11): 1135–41. doi:10.1038/ncb1187. PMID 15502821.
• Kline SL, Cheeseman IM, Hori T, Fukagawa T, Desai A (April 2006). "The human Mis12 complex is required for kinetochore assembly and proper chromosome segregation". The Journal of Cell Biology. 173 (1): 9–17. doi:10.1083/jcb.200509158. PMC 2063780. PMID 16585270.