MIS12

Protein MIS12 homolog is a protein that in humans is encoded by the MIS12 gene.[5][6][7]

MIS12
Identifiers
Aliases	MIS12, 2510025F08Rik, KNTC2AP, MTW1, hMis12, kinetochore complex component, MIS12 kinetochore complex component
External IDs	OMIM: 609178 MGI: 1914389 HomoloGene: 11429 GeneCards: MIS12
Gene location (Human) Chr. Chromosome 17 (human)[1] Band 17p13.2 Start 5,486,285 bp[1] End 5,490,814 bp[1]
Gene location (Mouse) Chr. Chromosome 11 (mouse)[2] Band 11|11 B4 Start 71,019,611 bp[2] End 71,027,371 bp[2]
RNA expression pattern More reference expression data
Gene ontology Molecular function • GO:0001948 protein binding Cellular component • chromosome • cytosol • MIS12/MIND type complex • chromosome, centromeric region • cell nucleus • kinetochore • nuclear MIS12/MIND complex • condensed chromosome kinetochore Biological process • chromosome segregation • cell division • cell cycle • kinetochore assembly • attachment of mitotic spindle microtubules to kinetochore • GO:0007067 mitotic cell cycle • protein localization to kinetochore • mitotic sister chromatid segregation Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	79003	67139
Ensembl	ENSG00000167842	ENSMUSG00000040599
UniProt	Q9H081	Q9CY25
RefSeq (mRNA)	NM_001258217 NM_001258218 NM_001258219 NM_001258220 NM_024039	NM_025993
RefSeq (protein)	NP_001245146 NP_001245147 NP_001245148 NP_001245149 NP_076944	NP_080269
Location (UCSC)	Chr 17: 5.49 – 5.49 Mb	Chr 11: 71.02 – 71.03 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

Interactions

MIS12 has been shown to interact with NSL1,[8] ZWINT,[8][9] CASC5,[8][9] Polyamine-modulated factor 1,[8][9] NDC80,[8][9] DSN1[8][9] and CBX5.[8]

References

1. GRCh38: Ensembl release 89: ENSG00000167842 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000040599 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Wiemann S, Weil B, Wellenreuther R, Gassenhuber J, Glassl S, Ansorge W, Bocher M, Blocker H, Bauersachs S, Blum H, Lauber J, Dusterhoft A, Beyer A, Kohrer K, Strack N, Mewes HW, Ottenwalder B, Obermaier B, Tampe J, Heubner D, Wambutt R, Korn B, Klein M, Poustka A (Mar 2001). "Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs". Genome Res. 11 (3): 422–35. doi:10.1101/gr.GR1547R. PMC 311072. PMID 11230166.
6. Goshima G, Kiyomitsu T, Yoda K, Yanagida M (Jan 2003). "Human centromere chromatin protein hMis12, essential for equal segregation, is independent of CENP-A loading pathway". J Cell Biol. 160 (1): 25–39. doi:10.1083/jcb.200210005. PMC 2172742. PMID 12515822.
7. "Entrez Gene: MIS12 MIS12, MIND kinetochore complex component, homolog (yeast)".
8. Obuse, Chikashi; Iwasaki Osamu; Kiyomitsu Tomomi; Goshima Gohta; Toyoda Yusuke; Yanagida Mitsuhiro (Nov 2004). "A conserved Mis12 centromere complex is linked to heterochromatic HP1 and outer kinetochore protein Zwint-1". Nat. Cell Biol. England. 6 (11): 1135–41. doi:10.1038/ncb1187. ISSN 1465-7392. PMID 15502821.
9. Cheeseman, Iain M; Niessen Sherry; Anderson Scott; Hyndman Francie; Yates John R; Oegema Karen; Desai Arshad (Sep 2004). "A conserved protein network controls assembly of the outer kinetochore and its ability to sustain tension". Genes Dev. United States. 18 (18): 2255–68. doi:10.1101/gad.1234104. ISSN 0890-9369. PMC 517519. PMID 15371340.

Further reading

• Hartley JL, Temple GF, Brasch MA (2001). "DNA cloning using in vitro site-specific recombination". Genome Res. 10 (11): 1788–95. doi:10.1101/gr.143000. PMC 310948. PMID 11076863.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Cheeseman IM, Niessen S, Anderson S, et al. (2004). "A conserved protein network controls assembly of the outer kinetochore and its ability to sustain tension". Genes Dev. 18 (18): 2255–68. doi:10.1101/gad.1234104. PMC 517519. PMID 15371340.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Wiemann S, Arlt D, Huber W, et al. (2004). "From ORFeome to biology: a functional genomics pipeline". Genome Res. 14 (10B): 2136–44. doi:10.1101/gr.2576704. PMC 528930. PMID 15489336.
• Obuse C, Iwasaki O, Kiyomitsu T, et al. (2004). "A conserved Mis12 centromere complex is linked to heterochromatic HP1 and outer kinetochore protein Zwint-1". Nat. Cell Biol. 6 (11): 1135–41. doi:10.1038/ncb1187. PMID 15502821.
• Mehrle A, Rosenfelder H, Schupp I, et al. (2006). "The LIFEdb database in 2006". Nucleic Acids Res. 34 (Database issue): D415–8. doi:10.1093/nar/gkj139. PMC 1347501. PMID 16381901.
• Kline SL, Cheeseman IM, Hori T, et al. (2006). "The human Mis12 complex is required for kinetochore assembly and proper chromosome segregation". J. Cell Biol. 173 (1): 9–17. doi:10.1083/jcb.200509158. PMC 2063780. PMID 16585270.