PLXNA2

Plexin-A2 is a protein that in humans is coded by the PLXNA2 gene.[5][6]

PLXNA2
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 3Q3J
Identifiers
Aliases	PLXNA2, OCT, PLXN2, plexin A2
External IDs	OMIM: 601054 MGI: 107684 HomoloGene: 56427 GeneCards: PLXNA2
Gene location (Human) Chr. Chromosome 1 (human)[1] Band 1q32.2 Start 208,022,242 bp[1] End 208,244,384 bp[1]
Gene location (Mouse) Chr. Chromosome 1 (mouse)[2] Band 1|1 H6 Start 194,618,218 bp[2] End 194,816,869 bp[2]
RNA expression pattern More reference expression data
Gene ontology Molecular function • GO:0001948 protein binding • semaphorin receptor activity • identical protein binding Cellular component • integral component of membrane • cell membrane • semaphorin receptor complex • membrane • integral component of plasma membrane Biological process • somitogenesis • cell surface receptor signaling pathway • regulation of axon extension involved in axon guidance • cerebellar granule cell precursor tangential migration • branchiomotor neuron axon guidance • limb bud formation • neural tube development • semaphorin-plexin signaling pathway • signal transduction • pharyngeal system development • centrosome localization • regulation of cell migration • negative regulation of cell adhesion • regulation of cell shape • GO:0043087, GO:0032313, GO:0032319, GO:0032314, GO:0043088 regulation of GTPase activity • positive regulation of axonogenesis • semaphorin-plexin signaling pathway involved in axon guidance Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	5362	18845
Ensembl	ENSG00000076356	ENSMUSG00000026640
UniProt	O75051	P70207
RefSeq (mRNA)	NM_025179	NM_008882
RefSeq (protein)	NP_079455	NP_032908
Location (UCSC)	Chr 1: 208.02 – 208.24 Mb	Chr 1: 194.62 – 194.82 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

This gene encodes a member of the plexin-A family of semaphorin co-receptors. Semaphorins are a large family of secreted or membrane-bound proteins that mediate repulsive effects on axon pathfinding during nervous system development. A subset of semaphorins are recognized by plexin-A/neuropilin transmembrane receptor complexes, triggering a cellular signal transduction cascade that leads to axon repulsion. This plexin-A family member is thought to transduce signals from semaphorin-3A and -3C.[6]

In some studies, the PLXNA2 gene is associated with schizophrenia.[7] and anxiety.[8]

References

1. GRCh38: Ensembl release 89: ENSG00000076356 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000026640 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Maestrini E, Tamagnone L, Longati P, Cremona O, Gulisano M, Bione S, Tamanini F, Neel BG, Toniolo D, Comoglio PM (Mar 1996). "A family of transmembrane proteins with homology to the MET-hepatocyte growth factor receptor". Proc Natl Acad Sci USA. 93 (2): 674–8. doi:10.1073/pnas.93.2.674. PMC 40111. PMID 8570614.
6. "Entrez Gene: PLXNA2 plexin A2".
7. Gene Overview of All Published Schizophrenia-Association Studies for PLXNA2 Archived 2009-02-21 at the Wayback Machine - база данных SZGene, сайт Schizophrenia Research Forum
8. Wray NR, James MR, Mah SP, Nelson M, Andrews G, Sullivan PF, Montgomery GW, Birley AJ, Braun A, Martin NG (March 2007). "Anxiety and comorbid measures associated with PLXNA2". Arch. Gen. Psychiatry. 64 (3): 318–26. doi:10.1001/archpsyc.64.3.318. PMID 17339520. Archived from the original on 2009-07-20. Retrieved 2009-02-11.

Further reading

• Negishi M, Oinuma I, Katoh H (2005). "Plexins: axon guidance and signal transduction". Cell. Mol. Life Sci. 62 (12): 1363–71. doi:10.1007/s00018-005-5018-2. PMID 15818466.
• Seki N, Ohira M, Nagase T, et al. (1998). "Characterization of cDNA clones in size-fractionated cDNA libraries from human brain". DNA Res. 4 (5): 345–9. doi:10.1093/dnares/4.5.345. PMID 9455484.
• Tamagnone L, Artigiani S, Chen H, et al. (1999). "Plexins are a large family of receptors for transmembrane, secreted, and GPI-anchored semaphorins in vertebrates". Cell. 99 (1): 71–80. doi:10.1016/S0092-8674(00)80063-X. PMID 10520995.
• Nakayama M, Kikuno R, Ohara O (2003). "Protein–Protein Interactions Between Large Proteins: Two-Hybrid Screening Using a Functionally Classified Library Composed of Long cDNAs". Genome Res. 12 (11): 1773–84. doi:10.1101/gr.406902. PMC 187542. PMID 12421765.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Clark HF, Gurney AL, Abaya E, et al. (2003). "The Secreted Protein Discovery Initiative (SPDI), a Large-Scale Effort to Identify Novel Human Secreted and Transmembrane Proteins: A Bioinformatics Assessment". Genome Res. 13 (10): 2265–70. doi:10.1101/gr.1293003. PMC 403697. PMID 12975309.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: Large-scale identification and characterization of putative alternative promoters of human genes". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC 1356129. PMID 16344560.
• Mah S, Nelson MR, Delisi LE, et al. (2006). "Identification of the semaphorin receptor PLXNA2 as a candidate for susceptibility to schizophrenia". Mol. Psychiatry. 11 (5): 471–8. doi:10.1038/sj.mp.4001785. PMID 16402134.
• Fujii T, Iijima Y, Kondo H, et al. (2007). "Failure to confirm an association between the PLXNA2 gene and schizophrenia in a Japanese population". Prog. Neuropsychopharmacol. Biol. Psychiatry. 31 (4): 873–7. doi:10.1016/j.pnpbp.2007.01.027. PMID 17346868.