PCGF2

Polycomb group RING finger protein 2 is a protein that in humans is encoded by the PCGF2 gene.[5][6]

PCGF2
Identifiers
Aliases	PCGF2, MEL-18, RNF110, ZNF144, polycomb group ring finger 2, TPFS
External IDs	OMIM: 600346 MGI: 99161 HomoloGene: 5174 GeneCards: PCGF2
Gene location (Human) Chr. Chromosome 17 (human)[1] Band 17q12 Start 38,733,898 bp[1] End 38,749,817 bp[1]
Gene location (Mouse) Chr. Chromosome 11 (mouse)[2] Band 11 D|11 61.06 cM Start 97,688,823 bp[2] End 97,700,497 bp[2]
RNA expression pattern More reference expression data
Gene ontology Molecular function • metal ion binding • chromatin binding • GO:0001131, GO:0001151, GO:0001130, GO:0001204 DNA-binding transcription factor activity • DNA binding • GO:0001948 protein binding • promoter-specific chromatin binding Cellular component • nucleoplasm • cell nucleus • sex chromatin • nuclear body • PcG protein complex • PRC1 complex • nuclear chromatin Biological process • anterior/posterior pattern specification • transcription, DNA-templated • negative regulation of apoptotic signaling pathway • embryonic skeletal system morphogenesis • cellular response to hydrogen peroxide • histone acetylation • in utero embryonic development • regulation of transcription, DNA-templated • embryonic skeletal system development • negative regulation of transcription from RNA polymerase II promoter • histone H2A-K119 monoubiquitination • negative regulation of G0 to G1 transition • chromatin silencing Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	7703	22658
Ensembl	ENSG00000277258 ENSG00000278644	ENSMUSG00000018537
UniProt	P35227	P23798
RefSeq (mRNA)	NM_007144 NM_001369614 NM_001369615	NM_001163307 NM_001163308 NM_009545
RefSeq (protein)	NP_009075 NP_001356543 NP_001356544	NP_001156779 NP_001156780 NP_033571
Location (UCSC)	Chr 17: 38.73 – 38.75 Mb	Chr 11: 97.69 – 97.7 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

Function

The protein encoded by this gene contains a RING finger motif and is similar to the polycomb group (PcG) gene products. PcG gene products form complexes via protein-protein interaction and maintain the transcription repression of genes involved in embryogenesis, cell cycles, and tumorigenesis. This protein was shown to act as a negative regulator of transcription and has tumor suppressor activity. The expression of this gene was detected in various tumor cells, but is limited in neural organs in normal tissues. Knockout studies in mice suggested that this protein may negatively regulate the expression of different cytokines, chemokines, and chemokine receptors, and thus plays an important role in lymphocyte differentiation and migration, as well as in immune responses.[6]

References

1. ENSG00000278644 GRCh38: Ensembl release 89: ENSG00000277258, ENSG00000278644 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000018537 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Ishida A, Asano H, Hasegawa M, Koseki H, Ono T, Yoshida MC, Taniguchi M, Kanno M (July 1993). "Cloning and chromosome mapping of the human Mel-18 gene which encodes a DNA-binding protein with a new 'RING-finger' motif". Gene. 129 (2): 249–55. doi:10.1016/0378-1119(93)90275-8. PMID 8325509.
6. "Entrez Gene: PCGF2 polycomb group ring finger 2".

Further reading

• Hartley JL, Temple GF, Brasch MA (November 2000). "DNA cloning using in vitro site-specific recombination". Genome Research. 10 (11): 1788–95. doi:10.1101/gr.143000. PMC 310948. PMID 11076863.
• Wiemann S, Weil B, Wellenreuther R, Gassenhuber J, Glassl S, Ansorge W, Böcher M, Blöcker H, Bauersachs S, Blum H, Lauber J, Düsterhöft A, Beyer A, Köhrer K, Strack N, Mewes HW, Ottenwälder B, Obermaier B, Tampe J, Heubner D, Wambutt R, Korn B, Klein M, Poustka A (March 2001). "Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs". Genome Research. 11 (3): 422–35. doi:10.1101/gr.GR1547R. PMC 311072. PMID 11230166.
• Kimura M, Koseki Y, Yamashita M, Watanabe N, Shimizu C, Katsumoto T, Kitamura T, Taniguchi M, Koseki H, Nakayama T (August 2001). "Regulation of Th2 cell differentiation by mel-18, a mammalian polycomb group gene". Immunity. 15 (2): 275–87. doi:10.1016/S1074-7613(01)00182-0. PMID 11520462.
• Miyazaki K, Inoue H, Onai N, Ishihara H, Kanno M (February 2002). "Chemokine-mediated thymopoiesis is regulated by a mammalian Polycomb group gene, mel-18". Immunology Letters. 80 (2): 139–43. doi:10.1016/S0165-2478(01)00315-7. PMID 11750047.
• Levine SS, Weiss A, Erdjument-Bromage H, Shao Z, Tempst P, Kingston RE (September 2002). "The core of the polycomb repressive complex is compositionally and functionally conserved in flies and humans". Molecular and Cellular Biology. 22 (17): 6070–8. doi:10.1128/MCB.22.17.6070-6078.2002. PMC 134016. PMID 12167701.
• Suzuki M, Mizutani-Koseki Y, Fujimura Y, Miyagishima H, Kaneko T, Takada Y, Akasaka T, Tanzawa H, Takihara Y, Nakano M, Masumoto H, Vidal M, Isono K, Koseki H (September 2002). "Involvement of the Polycomb-group gene Ring1B in the specification of the anterior-posterior axis in mice". Development. 129 (18): 4171–83. PMID 12183370.
• Matsuo F, Yano K, Saito H, Morotomi K, Kato M, Yoshimoto M, Kasumi F, Akiyama F, Sakamoto G, Miki Y (2002). "Mutation analysis of the mel-18 gene that shows decreased expression in human breast cancer cell lines". Breast Cancer. 9 (1): 33–8. doi:10.1007/BF02967544. PMID 12196719.
• Wiemann S, Arlt D, Huber W, Wellenreuther R, Schleeger S, Mehrle A, Bechtel S, Sauermann M, Korf U, Pepperkok R, Sültmann H, Poustka A (October 2004). "From ORFeome to biology: a functional genomics pipeline". Genome Research. 14 (10B): 2136–44. doi:10.1101/gr.2576704. PMC 528930. PMID 15489336.
• Kimura K, Wakamatsu A, Suzuki Y, Ota T, Nishikawa T, Yamashita R, Yamamoto J, Sekine M, Tsuritani K, Wakaguri H, Ishii S, Sugiyama T, Saito K, Isono Y, Irie R, Kushida N, Yoneyama T, Otsuka R, Kanda K, Yokoi T, Kondo H, Wagatsuma M, Murakawa K, Ishida S, Ishibashi T, Takahashi-Fujii A, Tanase T, Nagai K, Kikuchi H, Nakai K, Isogai T, Sugano S (January 2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes". Genome Research. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC 1356129. PMID 16344560.
• Mehrle A, Rosenfelder H, Schupp I, del Val C, Arlt D, Hahne F, Bechtel S, Simpson J, Hofmann O, Hide W, Glatting KH, Huber W, Pepperkok R, Poustka A, Wiemann S (January 2006). "The LIFEdb database in 2006". Nucleic Acids Research. 34 (Database issue): D415–8. doi:10.1093/nar/gkj139. PMC 1347501. PMID 16381901.
• Silva J, García JM, Peña C, García V, Domínguez G, Suárez D, Camacho FI, Espinosa R, Provencio M, España P, Bonilla F (December 2006). "Implication of polycomb members Bmi-1, Mel-18, and Hpc-2 in the regulation of p16INK4a, p14ARF, h-TERT, and c-Myc expression in primary breast carcinomas". Clinical Cancer Research. 12 (23): 6929–36. doi:10.1158/1078-0432.CCR-06-0788. PMID 17145810.
• Guo WJ, Datta S, Band V, Dimri GP (February 2007). "Mel-18, a polycomb group protein, regulates cell proliferation and senescence via transcriptional repression of Bmi-1 and c-Myc oncoproteins". Molecular Biology of the Cell. 18 (2): 536–46. doi:10.1091/mbc.E06-05-0447. PMC 1783768. PMID 17151361.
• Wiederschain D, Chen L, Johnson B, Bettano K, Jackson D, Taraszka J, Wang YK, Jones MD, Morrissey M, Deeds J, Mosher R, Fordjour P, Lengauer C, Benson JD (July 2007). "Contribution of polycomb homologues Bmi-1 and Mel-18 to medulloblastoma pathogenesis". Molecular and Cellular Biology. 27 (13): 4968–79. doi:10.1128/MCB.02244-06. PMC 1951487. PMID 17452456.
• Guo WJ, Zeng MS, Yadav A, Song LB, Guo BH, Band V, Dimri GP (June 2007). "Mel-18 acts as a tumor suppressor by repressing Bmi-1 expression and down-regulating Akt activity in breast cancer cells". Cancer Research. 67 (11): 5083–9. doi:10.1158/0008-5472.CAN-06-4368. PMC 2386662. PMID 17545584.
• Szafranski K, Schindler S, Taudien S, Hiller M, Huse K, Jahn N, Schreiber S, Backofen R, Platzer M (2007). "Violating the splicing rules: TG dinucleotides function as alternative 3' splice sites in U2-dependent introns". Genome Biology. 8 (8): R154. doi:10.1186/gb-2007-8-8-r154. PMC 2374985. PMID 17672918.