PAG1

Phosphoprotein associated with glycosphingolipid-enriched microdomains 1 is a protein that in humans is encoded by the PAG1 gene.[5][6]

PAG1
Identifiers
Aliases	PAG1, CBP, PAG, phosphoprotein membrane anchor with glycosphingolipid microdomains 1
External IDs	OMIM: 605767 MGI: 2443160 HomoloGene: 10198 GeneCards: PAG1
Gene location (Human) Chr. Chromosome 8 (human)[1] Band 8q21.13 Start 80,967,810 bp[1] End 81,112,068 bp[1]
Gene location (Mouse) Chr. Chromosome 3 (mouse)[2] Band 3|3 A1 Start 9,687,479 bp[2] End 9,833,679 bp[2]
RNA expression pattern More reference expression data
Gene ontology Molecular function • SH2 domain binding • GO:0001948 protein binding • transmembrane receptor protein tyrosine kinase adaptor activity Cellular component • integral component of membrane • membrane raft • cell membrane • membrane • integral component of plasma membrane • intracellular Biological process • GO:0007243 intracellular signal transduction • T cell receptor signaling pathway • adaptive immune response • regulation of T cell activation • signal transduction • immune system process • positive regulation of signal transduction • transmembrane receptor protein tyrosine kinase signaling pathway • negative regulation of T cell activation Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	55824	94212
Ensembl	ENSG00000076641	ENSMUSG00000027508
UniProt	Q9NWQ8	Q3U1F9
RefSeq (mRNA)	NM_018440	NM_001195031 NM_053182
RefSeq (protein)	NP_060910	NP_001181960 NP_444412
Location (UCSC)	Chr 8: 80.97 – 81.11 Mb	Chr 3: 9.69 – 9.83 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

The protein encoded by this gene is a type III transmembrane adaptor protein that binds to the tyrosine kinase csk protein. It is thought to be involved in the regulation of T cell activation.[6]

Interactions

PAG1 has been shown to interact with FYN,[5] C-src tyrosine kinase,[5] Sodium-hydrogen antiporter 3 regulator 1[7] and Abl gene.[8]

References

1. GRCh38: Ensembl release 89: ENSG00000076641 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000027508 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Brdicka T, Pavlistová D, Leo A, Bruyns E, Korínek V, Angelisová P, Scherer J, Shevchenko A, Hilgert I, Cerný J, Drbal K, Kuramitsu Y, Kornacker B, Horejsí V, Schraven B (May 2000). "Phosphoprotein associated with glycosphingolipid-enriched microdomains (PAG), a novel ubiquitously expressed transmembrane adaptor protein, binds the protein tyrosine kinase csk and is involved in regulation of T cell activation". The Journal of Experimental Medicine. 191 (9): 1591–604. doi:10.1084/jem.191.9.1591. PMC 2213442. PMID 10790433.
6. "Entrez Gene: PAG1 phosphoprotein associated with glycosphingolipid microdomains 1".
7. Brdicková N, Brdicka T, Andera L, Spicka J, Angelisová P, Milgram SL, Horejsí V (October 2001). "Interaction between two adapter proteins, PAG and EBP50: a possible link between membrane rafts and actin cytoskeleton". FEBS Letters. 507 (2): 133–6. doi:10.1016/S0014-5793(01)02955-6. PMID 11684085.
8. Wen ST, Van Etten RA (October 1997). "The PAG gene product, a stress-induced protein with antioxidant properties, is an Abl SH3-binding protein and a physiological inhibitor of c-Abl tyrosine kinase activity". Genes & Development. 11 (19): 2456–67. doi:10.1101/gad.11.19.2456. PMC 316562. PMID 9334312.

Further reading

• Wen ST, Van Etten RA (October 1997). "The PAG gene product, a stress-induced protein with antioxidant properties, is an Abl SH3-binding protein and a physiological inhibitor of c-Abl tyrosine kinase activity". Genes & Development. 11 (19): 2456–67. doi:10.1101/gad.11.19.2456. PMC 316562. PMID 9334312.
• Brdicková N, Brdicka T, Andera L, Spicka J, Angelisová P, Milgram SL, Horejsí V (October 2001). "Interaction between two adapter proteins, PAG and EBP50: a possible link between membrane rafts and actin cytoskeleton". FEBS Letters. 507 (2): 133–6. doi:10.1016/S0014-5793(01)02955-6. PMID 11684085.
• Tedoldi S, Paterson JC, Hansmann ML, Natkunam Y, Rüdiger T, Angelisova P, Du MQ, Roberton H, Roncador G, Sanchez L, Pozzobon M, Masir N, Barry R, Pileri S, Mason DY, Marafioti T, Horejsí V (January 2006). "Transmembrane adaptor molecules: a new category of lymphoid-cell markers". Blood. 107 (1): 213–21. doi:10.1182/blood-2005-06-2273. PMID 16160011.
• Jiang LQ, Feng X, Zhou W, Knyazev PG, Ullrich A, Chen Z (September 2006). "Csk-binding protein (Cbp) negatively regulates epidermal growth factor-induced cell transformation by controlling Src activation". Oncogene. 25 (40): 5495–506. doi:10.1038/sj.onc.1209554. PMID 16636672.
• Takeuchi S (June 2006). "Expression and purification of human PAG, a transmembrane adapter protein using an insect cell expression system and its structure basis". The Protein Journal. 25 (4): 295–9. doi:10.1007/s10930-006-9015-6. PMID 16947079.
• Roberts AE, Araki T, Swanson KD, Montgomery KT, Schiripo TA, Joshi VA, Li L, Yassin Y, Tamburino AM, Neel BG, Kucherlapati RS (January 2007). "Germline gain-of-function mutations in SOS1 cause Noonan syndrome". Nature Genetics. 39 (1): 70–4. doi:10.1038/ng1926. PMID 17143285.
• Smida M, Posevitz-Fejfar A, Horejsi V, Schraven B, Lindquist JA (July 2007). "A novel negative regulatory function of the phosphoprotein associated with glycosphingolipid-enriched microdomains: blocking Ras activation". Blood. 110 (2): 596–615. doi:10.1182/blood-2006-07-038752. PMID 17389760.