Olke C. Uhlenbeck

Olke C. Uhlenbeck is a biochemist presently at Northwestern University.[1] He was elected to the United States National Academy of Sciences in 1993 [2] and has published over 200 peer-reviewed articles.[3] His research group has led to many breakthroughs in RNA biochemistry, most notably the enzymatic synthesis of RNAs from synthetic DNA templates using T7 RNA polymerase.[4] Olke was a founding member of the RNA Society.[5] His father was theoretical physicist George Uhlenbeck.

O. C. Uhlenbeck
CitizenshipAmerican
Alma materUniversity of Michigan
Harvard University
Known forRNA synthesis from synthetic templates, RNA-protein interactions, RNA Biochemistry
Spouse(s)
(
m. 1965⁠–⁠1976)
Scientific career
FieldsBiochemistry
Biophysics
InstitutionsUniversity of Illinois
University of Colorado
Northwestern University
Doctoral advisorPaul Doty

Early contributions

As a graduate student in Paul Doty's lab, Uhlenbeck showed that the anticodon of tRNA was accessible to hybridization to oligonucleotides.[6] Later, as a Miller Research Fellow in Ignacio Tinoco, Jr.'s lab he helped define an original model for RNA secondary structure prediction.[7]

Personal life

Uhlenbeck's father was theoretical physicist George Uhlenbeck. He was married to Karen Uhlenbeck between 1965 and 1976.[8]

Contributions from the Uhlenbeck Lab

Olke is a longstanding contributor to RNA biochemistry. His group has shown many important findings as well as developed important tools for RNA biochemists. Notable contributions include:

  • Walker, G. C.; Uhlenbeck, OC; Bedows, E; Gumport, RI (1975). "T4-Induced RNA Ligase Joins Single-Stranded Oligoribonucleotides". Proceedings of the National Academy of Sciences. 72 (1): 122–6. Bibcode:1975PNAS...72..122W. doi:10.1073/pnas.72.1.122. PMC 432253. PMID 1090929.
  • England, Thomas E.; Uhlenbeck, Olke C. (1978). "3′-Terminal labelling of RNA with T4 RNA ligase". Nature. 275 (5680): 560–1. Bibcode:1978Natur.275..560E. doi:10.1038/275560a0. PMID 692735.
  • Milligan, John F.; Groebe, Duncan R.; Witherell, Gary W.; Uhlenbeck, Olke C. (1987). "Oligoribonucleotide synthesis using T7 RNA polymerase and synthetic DNA templates". Nucleic Acids Research. 15 (21): 8783–98. doi:10.1093/nar/15.21.8783. PMC 306405. PMID 3684574.
  • Milligan, John F.; Groebe, Duncan R.; Witherell, Gary W.; Uhlenbeck, Olke C. (1987). "Oligoribonucleotide synthesis using T7 RNA polymerase and synthetic DNA templates". Nucleic Acids Research. 15 (21): 8783–98. doi:10.1093/nar/15.21.8783. PMC 306405. PMID 3684574.
  • Hertel, Klemens J.; Herschlag, Daniel; Uhlenbeck, Olke C. (1994). "A Kinetic and Thermodynamic Framework for the Hammerhead Ribozyme Reaction". Biochemistry. 33 (11): 3374–85. doi:10.1021/bi00177a031. PMID 8136375.
  • Johansson, H. E. (1998). "A thermodynamic analysis of the sequence-specific binding of RNA by bacteriophage MS2 coat protein". Proceedings of the National Academy of Sciences. 95 (16): 9244–9. Bibcode:1998PNAS...95.9244J. doi:10.1073/pnas.95.16.9244. PMC 21323. PMID 9689065.
  • Sampson, J. R. (1988). "Biochemical and Physical Characterization of an Unmodified Yeast Phenylalanine Transfer RNA Transcribed in vitro". Proceedings of the National Academy of Sciences. 85 (4): 1033–7. Bibcode:1988PNAS...85.1033S. doi:10.1073/pnas.85.4.1033. JSTOR 30928. PMC 279695. PMID 3277187.
  • Sampson, JR; Direnzo, A.; Behlen, L.; Uhlenbeck, O. (1989). "Nucleotides in yeast tRNAPhe required for the specific recognition by its cognate synthetase". Science. 243 (4896): 1363–6. Bibcode:1989Sci...243.1363S. doi:10.1126/science.2646717. PMID 2646717.
  • Lariviere, F. J.; Wolfson, AD; Uhlenbeck, OC (2001). "Uniform Binding of Aminoacyl-tRNAs to Elongation Factor Tu by Thermodynamic Compensation". Science. 294 (5540): 165–8. Bibcode:2001Sci...294..165L. doi:10.1126/science.1064242. PMID 11588263.
gollark: I mean, they're evil, yes, but handwriting things is very slow and bad.
gollark: Wait, why did you not just use a printer?
gollark: You forgot strange kek, charm kek, up kek and down kek!
gollark: What if we make it so that proposals are *automatically* passed when the rules state they should be, and directly patch the code of the bot?
gollark: What if we make it so that votes are done by allowing each player to set a few cells of the initial state to a complex cellular automaton, and then the output of that after a few billion steps is parsed into the result of the vote?

See also

List of RNA biologists

References
  1. "Northwestern University Department of Molecular Biosciences The Uhlenbeck Lab Home". Biochem.northwestern.edu. Retrieved 2011-03-02.
  2. "National Academy of Sciences". Nasonline.org. Retrieved 2011-03-02.
  3. ""Uhlenbeck OC"[Author] - PubMed - NCBI". Ncbi.nlm.nih.gov. 2011-10-03. Retrieved 2011-12-02.
  4. Milligan, John F.; Groebe, Duncan R.; Witherell, Gary W.; Uhlenbeck, Olke C. (1987). "Oligoribonucleotide synthesis using T7 RNA polymerase and synthetic DNA templates". Nucleic Acids Research. 15 (21): 8783–98. doi:10.1093/nar/15.21.8783. PMC 306405. PMID 3684574.
  5. "An Imperfect Account of the Founding of the RNA Society". The RNA society.
  6. Uhlenbeck, Olke C.; Baller, Julie; Doty, Paul (1970). "Complementary Oligonucleotide Binding to the Anticodon Loop of fMet-transfer RNA". Nature. 225 (5232): 508–10. Bibcode:1970Natur.225..508U. doi:10.1038/225508a0. PMID 5411856.
  7. Tinoco, Ignacio; Uhlenbeck, Olke C.; Levine, Mark D. (1971). "Estimation of Secondary Structure in Ribonucleic Acids". Nature. 230 (5293): 362–7. Bibcode:1971Natur.230..362T. doi:10.1038/230362a0. PMID 4927725.
  8. Allyn Jackson (2018). "Interview with Karen Uhlenbeck". Celebratio Mathematica.
This article is issued from Wikipedia. The text is licensed under Creative Commons - Attribution - Sharealike. Additional terms may apply for the media files.