Olke C. Uhlenbeck

Olke C. Uhlenbeck is a biochemist presently at Northwestern University.[1] He was elected to the United States National Academy of Sciences in 1993 [2] and has published over 200 peer-reviewed articles.[3] His research group has led to many breakthroughs in RNA biochemistry, most notably the enzymatic synthesis of RNAs from synthetic DNA templates using T7 RNA polymerase.[4] Olke was a founding member of the RNA Society.[5] His father was theoretical physicist George Uhlenbeck.

O. C. Uhlenbeck
CitizenshipAmerican
Alma materUniversity of Michigan
Harvard University
Known forRNA synthesis from synthetic templates, RNA-protein interactions, RNA Biochemistry
Spouse(s)
(
m. 1965⁠–⁠1976)
Scientific career
FieldsBiochemistry
Biophysics
InstitutionsUniversity of Illinois
University of Colorado
Northwestern University
Doctoral advisorPaul Doty

Early contributions

As a graduate student in Paul Doty's lab, Uhlenbeck showed that the anticodon of tRNA was accessible to hybridization to oligonucleotides.[6] Later, as a Miller Research Fellow in Ignacio Tinoco, Jr.'s lab he helped define an original model for RNA secondary structure prediction.[7]

Personal life

Uhlenbeck's father was theoretical physicist George Uhlenbeck. He was married to Karen Uhlenbeck between 1965 and 1976.[8]

Contributions from the Uhlenbeck Lab

Olke is a longstanding contributor to RNA biochemistry. His group has shown many important findings as well as developed important tools for RNA biochemists. Notable contributions include:

  • Walker, G. C.; Uhlenbeck, OC; Bedows, E; Gumport, RI (1975). "T4-Induced RNA Ligase Joins Single-Stranded Oligoribonucleotides". Proceedings of the National Academy of Sciences. 72 (1): 122–6. Bibcode:1975PNAS...72..122W. doi:10.1073/pnas.72.1.122. PMC 432253. PMID 1090929.
  • England, Thomas E.; Uhlenbeck, Olke C. (1978). "3′-Terminal labelling of RNA with T4 RNA ligase". Nature. 275 (5680): 560–1. Bibcode:1978Natur.275..560E. doi:10.1038/275560a0. PMID 692735.
  • Milligan, John F.; Groebe, Duncan R.; Witherell, Gary W.; Uhlenbeck, Olke C. (1987). "Oligoribonucleotide synthesis using T7 RNA polymerase and synthetic DNA templates". Nucleic Acids Research. 15 (21): 8783–98. doi:10.1093/nar/15.21.8783. PMC 306405. PMID 3684574.
  • Milligan, John F.; Groebe, Duncan R.; Witherell, Gary W.; Uhlenbeck, Olke C. (1987). "Oligoribonucleotide synthesis using T7 RNA polymerase and synthetic DNA templates". Nucleic Acids Research. 15 (21): 8783–98. doi:10.1093/nar/15.21.8783. PMC 306405. PMID 3684574.
  • Hertel, Klemens J.; Herschlag, Daniel; Uhlenbeck, Olke C. (1994). "A Kinetic and Thermodynamic Framework for the Hammerhead Ribozyme Reaction". Biochemistry. 33 (11): 3374–85. doi:10.1021/bi00177a031. PMID 8136375.
  • Johansson, H. E. (1998). "A thermodynamic analysis of the sequence-specific binding of RNA by bacteriophage MS2 coat protein". Proceedings of the National Academy of Sciences. 95 (16): 9244–9. Bibcode:1998PNAS...95.9244J. doi:10.1073/pnas.95.16.9244. PMC 21323. PMID 9689065.
  • Sampson, J. R. (1988). "Biochemical and Physical Characterization of an Unmodified Yeast Phenylalanine Transfer RNA Transcribed in vitro". Proceedings of the National Academy of Sciences. 85 (4): 1033–7. Bibcode:1988PNAS...85.1033S. doi:10.1073/pnas.85.4.1033. JSTOR 30928. PMC 279695. PMID 3277187.
  • Sampson, JR; Direnzo, A.; Behlen, L.; Uhlenbeck, O. (1989). "Nucleotides in yeast tRNAPhe required for the specific recognition by its cognate synthetase". Science. 243 (4896): 1363–6. Bibcode:1989Sci...243.1363S. doi:10.1126/science.2646717. PMID 2646717.
  • Lariviere, F. J.; Wolfson, AD; Uhlenbeck, OC (2001). "Uniform Binding of Aminoacyl-tRNAs to Elongation Factor Tu by Thermodynamic Compensation". Science. 294 (5540): 165–8. Bibcode:2001Sci...294..165L. doi:10.1126/science.1064242. PMID 11588263.

See also

List of RNA biologists

References
  1. "Northwestern University Department of Molecular Biosciences The Uhlenbeck Lab Home". Biochem.northwestern.edu. Retrieved 2011-03-02.
  2. "National Academy of Sciences". Nasonline.org. Retrieved 2011-03-02.
  3. ""Uhlenbeck OC"[Author] - PubMed - NCBI". Ncbi.nlm.nih.gov. 2011-10-03. Retrieved 2011-12-02.
  4. Milligan, John F.; Groebe, Duncan R.; Witherell, Gary W.; Uhlenbeck, Olke C. (1987). "Oligoribonucleotide synthesis using T7 RNA polymerase and synthetic DNA templates". Nucleic Acids Research. 15 (21): 8783–98. doi:10.1093/nar/15.21.8783. PMC 306405. PMID 3684574.
  5. "An Imperfect Account of the Founding of the RNA Society". The RNA society.
  6. Uhlenbeck, Olke C.; Baller, Julie; Doty, Paul (1970). "Complementary Oligonucleotide Binding to the Anticodon Loop of fMet-transfer RNA". Nature. 225 (5232): 508–10. Bibcode:1970Natur.225..508U. doi:10.1038/225508a0. PMID 5411856.
  7. Tinoco, Ignacio; Uhlenbeck, Olke C.; Levine, Mark D. (1971). "Estimation of Secondary Structure in Ribonucleic Acids". Nature. 230 (5293): 362–7. Bibcode:1971Natur.230..362T. doi:10.1038/230362a0. PMID 4927725.
  8. Allyn Jackson (2018). "Interview with Karen Uhlenbeck". Celebratio Mathematica.
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